Patents by Inventor Alexander Sperl

Alexander Sperl has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220331804
    Abstract: The present invention generally relates to systems and techniques for manipulating fluids and/or making droplets. In certain aspects, the present invention generally relates to droplet production. The droplets may be formed from fluids from different sources. In one set of embodiments, the present invention is directed to a microfluidic device comprising a plurality of droplet-making units, and/or other fluidic units, which may be substantially identical in some cases. Substantially each of the fluidic units may be in fluidic communication with a different source of a first fluid and a common source of a second fluid, in certain embodiments. In one aspect, substantially the same pressure may be applied to substantially all of the different sources of fluid, which may be used to cause fluid to move from the different sources into the microfluidic device. In some cases, the fluids may interact within the fluidic units, e.g., by reacting, or for the production of droplets within the microfluidic device.
    Type: Application
    Filed: June 10, 2022
    Publication date: October 20, 2022
    Applicant: President and Fellows of Harvard College
    Inventors: David A. Weitz, Ralph Alexander Sperling, Adam R. Abate
  • Patent number: 11389800
    Abstract: The present invention generally relates to systems and techniques for manipulating fluids and/or making droplets. In certain aspects, the present invention generally relates to droplet production. The droplets may be formed from fluids from different sources. In one set of embodiments, the present invention is directed to a microfluidic device comprising a plurality of droplet-making units, and/or other fluidic units, which may be substantially identical in some cases. Substantially each of the fluidic units may be in fluidic communication with a different source of a first fluid and a common source of a second fluid, in certain embodiments. In one aspect, substantially the same pressure may be applied to substantially all of the different sources of fluid, which may be used to cause fluid to move from the different sources into the microfluidic device. In some cases, the fluids may interact within the fluidic units, e.g., by reacting, or for the production of droplets within the microfluidic device.
    Type: Grant
    Filed: September 27, 2012
    Date of Patent: July 19, 2022
    Assignee: President and Fellows of Harvard College
    Inventors: Ralph Alexander Sperling, Adam R. Abate, David A. Weitz
  • Publication number: 20200309141
    Abstract: An adjustment mechanism variably adjusts the cross-section of a compressor inlet. The adjustment mechanism comprises a plurality of rotatable orifice elements and a transmission ring. Each orifice element has a plate body, a coupling element and a bearing pin. The transmission ring is mechanically coupled to the orifice elements via the coupling elements. One of the orifice elements is configured as a drive orifice element. The bearing pin of the drive orifice element is configured as an elongated bearing pin. The elongated bearing pin is configured longer than the bearing pins of the other orifice elements. Furthermore, the elongated bearing pin is adapted to be coupled to an actuation system such that when the drive orifice element is moved by the actuation system, movement is transmitted from the drive orifice element via the transmission ring to the other orifice elements.
    Type: Application
    Filed: March 10, 2020
    Publication date: October 1, 2020
    Inventors: Aleksandar Vuletic, Jason Walkingshaw, Sascha Karstadt, Oliver Weber, Alexander Sperle
  • Publication number: 20190101748
    Abstract: A method for operating a pulsed laser system includes the steps of pumping a laser resonator of the pulsed laser system by means of a pump source in order to generate operating laser pulses at an operating energy level; and coupling the operating laser pulses with a focusing element into an optical fiber. A step of cleaning the optical fiber by means of cleaning laser pulses is performed prior to generating the operating laser pulses. The laser resonator of the pulsed laser system is pumped by means of the pump source in order to generate the cleaning laser pulses at one or more cleaning energy levels between a laser threshold and the operating energy level.
    Type: Application
    Filed: October 4, 2017
    Publication date: April 4, 2019
    Inventors: Werner Hiereth, Michael Rampp, Alexander Sperl
  • Publication number: 20170030920
    Abstract: The present invention discloses a method for separating nanoparticles with a controlled number of active groups is disclosed. First, a plurality of nanoparticles are provided, wherein the surface of the nanoparticle comprises a plurality of first active groups. Next, a plurality of functional ligands are provided, wherein the functional ligand comprises at least one second active group and at least one third active group. Then, a binding process is performed to bind the nanoparticle with the functional ligand, wherein the first active group connects with the second active group. After the binding process, a converting process and a separation process are performed to isolate a plurality of nanoparticles with a controlled number of the fifth active groups. The controlled number is integers from 0 to 10.
    Type: Application
    Filed: October 14, 2016
    Publication date: February 2, 2017
    Inventors: Walter Hong-Shong Chang, Jimmy Kuan-Jung Li, Ralph Alexander Sperling, Teresa Pellegrino, Wolfgang Parak
  • Patent number: 9494593
    Abstract: The present invention discloses a method for separating nanoparticles with a controlled number of active groups is disclosed. First, a plurality of nanoparticles are provided, wherein the surface of the nanoparticle comprises a plurality of first active groups. Next, a plurality of functional ligands are provided, wherein the functional ligand comprises at least one second active group and at least one third active group. Then, a binding process is performed to bind the nanoparticle with the functional ligand, wherein the first active group connects with the second active group. After the binding process, a separation process is performed to isolate a plurality of nanoparticles with a controlled number of the third active groups. The controlled number is integers from 0 to 10.
    Type: Grant
    Filed: December 14, 2005
    Date of Patent: November 15, 2016
    Assignee: CHUNG YUAN CHRISTIAN UNIVERSITY
    Inventors: Walter Hong-Shong Chang, Jimmy Kuan-Jung Li, Ralph Alexander Sperling, Teresa Pellegrino, Wolfgang Parak
  • Publication number: 20160008778
    Abstract: Devices and methods for dividing droplets are generally described. In some embodiments, an article may comprise a fluidic channel comprising an array of obstructions. In certain embodiments, the arrangement of obstructions in the array may affect the flow path of fluid in the channel. For example, the array of obstructions may be used to convert a polydisperse population of droplets into a relatively monodisperse population of droplets. Passing a polydisperse population of droplets through the array may result in the division of droplets such that the population of droplets exiting the array has a narrower distribution in the characteristic dimensions of the droplets. The arrangement of obstructions in the array may allow for high-throughput production of a substantially monodisperse population of droplets in some cases. In some embodiments, the population of droplets exiting the array may be converted into particles.
    Type: Application
    Filed: March 5, 2014
    Publication date: January 14, 2016
    Inventors: David A. Weitz, Esther Amstad, Ralph Alexander Sperling
  • Publication number: 20140338753
    Abstract: The present invention generally relates to systems and techniques for manipulating fluids and/or making droplets. In certain aspects, the present invention generally relates to droplet production. The droplets may be formed from fluids from different sources. In one set of embodiments, the present invention is directed to a microfluidic device comprising a plurality of droplet-making units, and/or other fluidic units, which may be substantially identical in some cases. Substantially each of the fluidic units may be in fluidic communication with a different source of a first fluid and a common source of a second fluid, in certain embodiments. In one aspect, substantially the same pressure may be applied to substantially all of the different sources of fluid, which may be used to cause fluid to move from the different sources into the microfluidic device. In some cases, the fluids may interact within the fluidic units, e.g., by reacting, or for the production of droplets within the microfluidic device.
    Type: Application
    Filed: September 27, 2012
    Publication date: November 20, 2014
    Inventors: Ralph Alexander Sperling, Adam R. Abate, David A. Weitz