Patents by Inventor Alexander Stafford
Alexander Stafford has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240108709Abstract: The present invention provides vaccine compositions and methods of producing such compositions. Other embodiments of the invention include methods of treating a pathogen infection, methods of vaccinating a subject against a pathogen infection, and methods for treating an antibiotic-resistance bacterial infection in a subject in need thereof. In further embodiments, the invention includes methods of decreasing the level of a pathogen in a subject having a pathogen infection, methods of increasing the surviving rate of a subject having a pathogen infection, methods of reducing the level of pain associated with a pathogen infection, and methods of reducing the level of distress associated with a pathogen infection in a subject in need thereof. Novel scaffold compositions and opsonin-bound or lectin-bound pathogen compositions, and uses thereof, are also provided herein.Type: ApplicationFiled: March 20, 2023Publication date: April 4, 2024Applicant: President and Fellows of Harvard CollegeInventors: Michael Super, Edward J. Doherty, Mark Joseph Cartwright, Des White, Alexander Stafford, Omar Abdel-Rahman Ali, Amanda Graveline, Donald E. Ingber, David J. Mooney, Benjamin Seiler
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Patent number: 11771767Abstract: The present invention is directed to reduced and highly oxidized polysaccharides, such as alginates, that are useful for encapsulating therapeutic or diagnostic agents, or lipid based nanoparticles, e.g., liposomes or virosomes, encapsulating therapeutic or diagnostic agents, prior to their delivery into a subject, as well as methods for making and using them.Type: GrantFiled: August 13, 2020Date of Patent: October 3, 2023Assignee: President and Fellows of Harvard CollegeInventors: David J. Mooney, Alexander Stafford, Rajiv Desai, Kathleen Martinick
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Patent number: 11638748Abstract: The present invention provides vaccine compositions and methods of producing such compositions. Other embodiments of the invention include methods of treating a pathogen infection, methods of vaccinating a subject against a pathogen infection, and methods for treating an antibiotic-resistance bacterial infection in a subject in need thereof. In further embodiments, the invention includes methods of decreasing the level of a pathogen in a subject having a pathogen infection, methods of increasing the surviving rate of a subject having a pathogen infection, methods of reducing the level of pain associated with a pathogen infection, and methods of reducing the level of distress associated with a pathogen infection in a subject in need thereof. Novel scaffold compositions and opsonin-bound or lectin-bound pathogen compositions, and uses thereof, are also provided herein.Type: GrantFiled: September 9, 2020Date of Patent: May 2, 2023Assignee: President and Fellows of Harvard CollegeInventors: Michael Super, Edward J. Doherty, Mark Joseph Cartwright, Des White, Alexander Stafford, Omar Abdel-Rahman Ali, Amanda Graveline, Donald E. Ingber, David J. Mooney, Benjamin Seiler
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Patent number: 11571089Abstract: A flammable tube has a plurality of air passages formed along the length of the flammable tube. A support member is positioned in an interior of the flammable tube. The support member is spaced apart from the lower end of the flammable tube. Solid fuel is positioned on the support member. A flame is introduced to the solid fuel which is within the interior of the tube which ignites the solid fuel, such as charcoal. The charcoal burns away the flammable tube and the support member. The flammable tube may be placed within a grill of the type used to cook food or other container that is nonflammable, and which provides a receptacle for the burning solid fuel without the need of a specialized grilling apparatus.Type: GrantFiled: July 26, 2019Date of Patent: February 7, 2023Inventor: Walter Alexander Stafford, IV
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Publication number: 20210170007Abstract: The present invention provides vaccine compositions and methods of producing such compositions. Other embodiments of the invention include methods of treating a pathogen infection, methods of vaccinating a subject against a pathogen infection, and methods for treating an antibiotic-resistance bacterial infection in a subject in need thereof. In further embodiments, the invention includes methods of decreasing the level of a pathogen in a subject having a pathogen infection, methods of increasing the surviving rate of a subject having a pathogen infection, methods of reducing the level of pain associated with a pathogen infection, and methods of reducing the level of distress associated with a pathogen infection in a subject in need thereof. Novel scaffold compositions and opsonin-bound or lectin-bound pathogen compositions, and uses thereof, are also provided herein.Type: ApplicationFiled: September 9, 2020Publication date: June 10, 2021Inventors: Michael Super, Edward J. Doherty, Mark Joseph Cartwright, Des White, Alexander Stafford, Omar Abdel-Rahman Ali, Amanda Graveline, Donald E. Ingber, David J. Mooney, Benjamin Seiler
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Publication number: 20210128790Abstract: The present disclosure provides click-crosslinked hydrogels and methods of use.Type: ApplicationFiled: September 15, 2020Publication date: May 6, 2021Inventors: Rajiv Desai, Neel Satish Joshi, David J. Mooney, Sandeep T. Koshy, Alexander Stafford
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Publication number: 20210022550Abstract: A flammable tube has a plurality of air passages formed along the length of the flammable tube. A support member is positioned in an interior of the flammable tube. The support member is spaced apart from the lower end of the flammable tube. Solid fuel is positioned on the support member. A flame is introduced to the solid fuel which is within the interior of the tube which ignites the solid fuel, such as charcoal. The charcoal burns away the flammable tube and the support member. The flammable tube may be placed within a grill of the type used to cook food or other container that is nonflammable, and which provides a receptacle for the burning solid fuel without the need of a specialized grilling apparatus.Type: ApplicationFiled: July 26, 2019Publication date: January 28, 2021Inventor: Walter Alexander Stafford, IV
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Publication number: 20200368359Abstract: The present invention is directed to reduced and highly oxidized polysaccharides, such as alginates, that are useful for encapsulating therapeutic or diagnostic agents, or lipid based nanoparticles, e.g., liposomes or virosomes, encapsulating therapeutic or diagnostic agents, prior to their delivery into a subject, as well as methods for making and using them.Type: ApplicationFiled: August 13, 2020Publication date: November 26, 2020Inventors: David J. Mooney, Alexander Stafford, Rajiv Desai, Kathleen Martinick
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Patent number: 10780171Abstract: The present invention is directed to reduced and highly oxidized polysaccharides, such as alginates, that are useful for encapsulating therapeutic or diagnostic agents, or lipid based nanoparticles, e.g., liposomes or virosomes, encapsulating therapeutic or diagnostic agents, prior to their delivery into a subject, as well as methods for making and using them.Type: GrantFiled: October 26, 2016Date of Patent: September 22, 2020Assignee: President and Fellows of Harvard CollegeInventors: David J. Mooney, Alexander Stafford, Rajiv Desai, Kathleen Martinick
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Publication number: 20180326073Abstract: The present invention is directed to reduced and highly oxidized polysaccharides, such as alginates, that are useful for encapsulating therapeutic or diagnostic agents, or lipid based nanoparticles, e.g., liposomes or virosomes, encapsulating therapeutic or diagnostic agents, prior to their delivery into a subject, as well as methods for making and using them.Type: ApplicationFiled: October 26, 2016Publication date: November 15, 2018Inventors: David J. Mooney, Alexander Stafford, Rajiv Desai, Kathleen Martinick
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Publication number: 20150186687Abstract: A mobile communications device includes a memory that stores instructions and a processor that executes the instructions. When executed by the processor, the instructions cause the mobile communications device to perform a process including capturing data at the direction of a user of the mobile communications device, analyzing the data captured to identify the data captured, automatically forwarding a request for content over a communications network in accordance with identifying the data captured, receiving the content over the communications network, and processing the content to provide output to the user.Type: ApplicationFiled: March 12, 2015Publication date: July 2, 2015Applicant: QYOO, LLC.Inventors: Jeffrey BERTHIAUME, John Ellis STAFIRA, Mark Alexander STAFFORD
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Patent number: 9008432Abstract: Information is arranged within a predetermined shape. The predetermined shape is captured in an image taken by a tangible image-capturing element of a device which captures images at the direction of a user. The device includes a tangible processor that analyzes the image captured by the image-capturing element to determine whether a predetermined shape is present in the image. The tangible processor determines an alignment of the predetermined shape when the predetermined shape is present in the image, and reads data within the predetermined shape in accordance with the determined alignment. The device automatically forwards a request for content over a communications network in accordance with the data read within the predetermined shape. The device receives the content over the network and displays the content.Type: GrantFiled: December 10, 2010Date of Patent: April 14, 2015Assignee: Qyoo, LLC.Inventors: Jeffrey Berthiaume, John Ellis Stafira, Mark Alexander Stafford
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Patent number: 8856384Abstract: A controller may help reduce network traffic that is associated with broadcasting of Dynamic Host Configuration Protocol (DHCP) packets by converting broadcast DHCP packets into unicast DHCP packets and forwarding the unicast DHCP packets to appropriate DHCP servers. The servers may be identified from a database of servers that is updated with DHCP server address information based on DHCP reply packets that are received by the controller from servers in the network. To convert DHCP request packets into unicast packets, the controller may modify address header fields of the packets such as Ethernet addresses and Internet Protocol (IP) addresses. The controller may forward the modified DHCP request packets to the server by providing packet forwarding rules such as flow table entries to the switches or by forwarding the modified DHCP request packets through the controller.Type: GrantFiled: October 14, 2011Date of Patent: October 7, 2014Assignee: Big Switch Networks, Inc.Inventors: Kanzhe Jiang, Shudong Zhou, Robert Edward Adams, Mandeep Singh Dhami, Alexander Stafford David Reimers
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Publication number: 20130097335Abstract: A controller may help reduce network traffic that is associated with broadcasting of Dynamic Host Configuration Protocol (DHCP) packets by converting broadcast DHCP packets into unicast DHCP packets and forwarding the unicast DHCP packets to appropriate DHCP servers. The servers may be identified from a database of servers that is updated with DHCP server address information based on DHCP reply packets that are received by the controller from servers in the network. To convert DHCP request packets into unicast packets, the controller may modify address header fields of the packets such as Ethernet addresses and Internet Protocol (IP) addresses. The controller may forward the modified DHCP request packets to the server by providing packet forwarding rules such as flow table entries to the switches or by forwarding the modified DHCP request packets through the controller.Type: ApplicationFiled: October 14, 2011Publication date: April 18, 2013Inventors: Kanzhe Jiang, Shudong Zhou, Robert Edward Adams, Mandeep Singh Dhami, Alexander Stafford David Reimers
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Publication number: 20110149090Abstract: Information is arranged within a predetermined shape. The predetermined shape is captured in an image taken by a tangible image-capturing element of a device which captures images at the direction of a user. The device includes a tangible processor that analyzes the image captured by the image-capturing element to determine whether a predetermined shape is present in the image. The tangible processor determines an alignment of the predetermined shape when the predetermined shape is present in the image, and reads data within the predetermined shape in accordance with the determined alignment. The device automatically forwards a request for content over a communications network in accordance with the data read within the predetermined shape. The device receives the content over the network and displays the content.Type: ApplicationFiled: December 10, 2010Publication date: June 23, 2011Applicant: QYOO, LLC.Inventors: Jeffrey BERTHIAUME, John Ellis STAFIRA, Mark Alexander STAFFORD
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Patent number: 5675767Abstract: A method for dynamically detecting loss of map integrity in a form of system-managed storage (SMS). In SMS, maps are used to define access paths to data and to allocate and reallocate storage resources among applications running thereon. The method steps include incorporating as an indivisible part of an overwriting commmand the duplication of map information by appending a portion of it to each data block in store, and detecting loss of map integrity as a function of a comparison mismatch between the portion stored with a counterpart data block and the map upon each read/write access.Type: GrantFiled: November 10, 1992Date of Patent: October 7, 1997Assignee: International Business Machines CorporationInventors: Robert Baird, Thomas Beretvas, Gerald Parks Bozman, Richard Roland Guyette, Paul Hodges, Alexander Stafford Lett, James Joseph Myers, William Harold Tetzlaff