Patents by Inventor Alexander Steinbüchel
Alexander Steinbüchel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10889839Abstract: Nonnaturally occurring organisms exhibiting improved carbon utilization and methods for production and use of these nonnaturally occurring organisms in chemical production from carbon containing feedstocks are provided.Type: GrantFiled: November 15, 2019Date of Patent: January 12, 2021Assignee: INVISTA North America S.a.r.l.Inventors: Alexander Steinbüchel, Jessica Eggers, Alexander Brett Foster, Jonathan Kennedy
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Publication number: 20200157582Abstract: Nonnaturally occurring organisms exhibiting improved carbon utilization and methods for production and use of these nonnaturally occurring organisms in chemical production from carbon containing feedstocks are provided.Type: ApplicationFiled: November 15, 2019Publication date: May 21, 2020Applicant: INVISTA NORTH AMERICA S.A.R.L.Inventors: Alexander STEINBÜCHEL, Jessica EGGERS, Alexander Brett FOSTER, Jonathan KENNEDY
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Patent number: 9877996Abstract: The present invention relates to a process for the enzymatic production of a dipeptide composition from a cyanophycin (CGP) or CGP-like polymer preparation by degrading the polymer preparation with an CGPase, a CGPase particularly adapted for said process, and the use of cyanophycin (CGP) or CGP-like polymers or fragments thereof, notably a dipeptide composition obtained by the process as defined above, as pharmaceutical composition, medicament, or as food or feed substitute.Type: GrantFiled: February 11, 2015Date of Patent: January 30, 2018Assignee: WESTFÄLISCHE WILHELMS-UNIVERSITÄT MÜNSTERInventors: Ahmed Sallam, Alexander Steinbüchel
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Patent number: 9567618Abstract: The present invention is concerned with methods for producing vanillin, feroyl-CoA, ferulic acid, coniferyl aldehyde and/or coniferyl alcohol. Also, the invention relates to microorganisms useful in such production method, and to the construction of such microorganisms.Type: GrantFiled: June 18, 2012Date of Patent: February 14, 2017Assignee: SYMRISE AGInventors: Stefan Lambrecht, Jens-Michael Hilmer, Manuel Pesaro, Jens Kroll, Gunda Hansen, Alexander Steinbüchel, Christian Fleige
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Publication number: 20150231194Abstract: The present invention relates to a process for the enzymatic production of a dipeptide composition from a cyanophycin (CGP) or CGP-like polymer preparation by degrading the polymer preparation with an CGPase, a CGPase particularly adapted for said process, and the use of cyanophycin (CGP) or CGP-like polymers or fragments thereof, notably a dipeptide composition obtained by the process as defined above, as pharmaceutical composition, medicament, or as food or feed substitute.Type: ApplicationFiled: February 11, 2015Publication date: August 20, 2015Applicant: WESTFÄLISCHE WILHELMS-UNIVERSITÄT MÜNSTERInventors: Ahmed SALLAM, Alexander Steinbüchel
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Patent number: 9109240Abstract: The invention is about E. coli host cells which are capable to convert glycerol to serinol. Furthermore, a process for producing serinol is disclosed, which comprises culturing E. coli host cells inactive for triosephosphate isomerase and active for dihydroxyacetone phosphate aminotransferase to convert glycerol to serinol, induction of conversion from glycerol to serinol by adding at least glycerol to the cell culture, and isolating serinol from the cell culture.Type: GrantFiled: September 5, 2013Date of Patent: August 18, 2015Assignees: BASF SE, Westfaelische Wilhelms Universitaet MuensterInventors: Lukas Maksym, Alexander Steinbuechel, Bjoern Andreessen
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Patent number: 8986960Abstract: Disclosed are microorganisms of the genus Cupriavidus or Ralstonia, which are genetically modified to express phosphomannose isomerase (EC5.3.1.8) and facilitated diffusion protein (EC1.3.1.74) for mannose uptake, and optionally mannofructokinase (EC2.7.1.4). The microorganisms also may be genetically modified to express xylose isomerase (EC 5.3.1.5), xylulokinase (E 2.7.1.17) and xylose proton symporter E or a high affinity ABC-transporter. The genetically modified microorganisms are capable of growing on mannose, xylose, arabinose, glucose, or galactose, or a combination thereof as the carbon source.Type: GrantFiled: July 15, 2011Date of Patent: March 24, 2015Assignee: Neste Oil OyjInventors: Shanna Sichwart, Birgit Haschenhermes, Daniel Bröker, Alexander Steinbüchel, Stephan Hetzler, Perttu Koskinen
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Patent number: 8980845Abstract: The present invention relates to a process for the enzymatic production of a dipeptide composition from a cyanophycin (CGP) or CGP-like polymer preparation by degrading the polymer preparation with an CGPase, a CGPase particularly adapted for said process, and the use of cyanophycin (CGP) or CGP-like polymers or fragments thereof, notably a dipeptide composition obtained by the process as defined above, as pharmaceutical composition, medicament, or as food or feed substitute.Type: GrantFiled: June 15, 2009Date of Patent: March 17, 2015Assignee: Westfälische Wilhelms-Universität MünsterInventors: Ahmed Sallam, Alexander Steinbüchel
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Publication number: 20140087428Abstract: The present invention is concerned with methods for producing vanillin, feroyl-CoA, ferulic acid, coniferyl aldehyde and/or coniferyl alcohol. Also, the invention relates to microorganisms useful in such production method, and to the construction of such microorganisms.Type: ApplicationFiled: June 18, 2012Publication date: March 27, 2014Inventors: Stefan Lambrecht, Jens-Michael Hilmer, Manuel Pesaro, Jens Kroll, Gunda Hansen, Alexander Steinbüchel, Christian Fleige
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Publication number: 20140080187Abstract: The invention is about E. coli host cells which are capable to convert glycerol to serinol. Furthermore, a process for producing serinol is disclosed, which comprises culturing E. coli host cells inactive for triosephosphate isomerase and active for dihydroxyacetone phosphate aminotransferase to convert glycerol to serinol, induction of conversion from glycerol to serinol by adding at least glycerol to the cell culture, and isolating serinol from the cell culture.Type: ApplicationFiled: September 5, 2013Publication date: March 20, 2014Applicants: Westfaelische Wilhelms-Universitaet Muenster, BASF SEInventors: Lukas Maksym, Alexander Steinbuechel, Bjoern Andreessen
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Publication number: 20120015413Abstract: The present invention relates to a microorganism of the genus Cupriavidus or Ralstonia, which is genetically modified to express phosphomannose isomerase (EC5.3.1.8) and facilitated diffusion protein for mannose uptake (EC1.3.1.74), and optionally mannofructokinase (EC2.7.1.4) and/or xylose isomerase (EC 5.3.1.5), xylulokinase (E 2.7.1.17) and xylose proton symporter E or a high affinity ABC-transporter. A modified Cupriavidus or Ralstonia host is capable of growing on mannose, xylose, arabinose, glucose, or galactose, or a combination thereof as the carbon source.Type: ApplicationFiled: July 15, 2011Publication date: January 19, 2012Applicant: NESTE OIL OYJInventors: Shanna Sichwart, Birgit Haschenhermes, Daniel Bröker, Alexander Steinbüchel, Stephan Hetzler, Perttu Koskinen
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Publication number: 20110118177Abstract: The present invention relates to a process for the enzymatic production of a dipeptide composition from a cyanophycin (CGP) or CGP-like polymer preparation by degrading the polymer preparation with an CGPase, a CGPase particularly adapted for said process, and the use of cyanophycin (CGP) or CGP-like polymers or fragments thereof, notably a dipeptide composition obtained by the process as defined above, as pharmaceutical composition, medicament, or as food or feed substitute.Type: ApplicationFiled: June 15, 2009Publication date: May 19, 2011Inventors: Ahmed Sallam, Alexander Steinbüchel
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Publication number: 20090203093Abstract: The present invention relates to a method of targeting a protein of interest to an intracellular hydrophobic inclusion body of a bacterial cell by means of a fusion protein comprising a hydrophobic targeting peptide operatively linked with said protein of interest; methods of microbial production of a lipophilic compound of interest by means of a recombinant bacterial host comprising intracellular inclusion bodies having at least one enzyme which is involved in the biosynthesis of said lipophilic compound targeted to said inclusion bodies; as well as corresponding fusion proteins, coding sequences, expression vectors and recombinant hosts.Type: ApplicationFiled: July 10, 2007Publication date: August 13, 2009Applicant: BASF SEInventors: Alexander Steinbüchel, Marc Wältermann, Jan Hänisch
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Patent number: 6770464Abstract: The present invention relates to a process for the production of poly (hydroxy fatty acids) as well as recombinant bacterial strains for carrying out the process. In addition, new poly(hydroxy fatty acids) and new substrates for the production of conventional and new poly(hydroxy fatty acids) are described. Moreover, the invention also relates to a DNA fragment, which codes for a PhaE and a PhaC component of the poly(hydroxy fatty acid) synthase from Thiocapsa pfennigii, as well as the corresponding poly (hydroxy fatty acid) synthase protein.Type: GrantFiled: February 8, 2001Date of Patent: August 3, 2004Assignee: Metabolix, Inc.Inventors: Alexander Steinbüchel, Mathias Liebergesell, Henry Valentin, Andreas Pries
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Patent number: 6759219Abstract: Coexpression of a polyhydroxyalkanoic acid synthase and either a fatty acid: acyl-CoA transferase or an acyl-CoA synthetase in cells enables the biosynthesis of polyester materials. Plasmids, bacteria, materials, and methods for the preparation of polyesters are disclosed.Type: GrantFiled: September 3, 1999Date of Patent: July 6, 2004Assignee: Metabolix, Inc.Inventors: Silke Hein, Brigitte Söhling, Gerhard Gottschalk, Alexander Steinbüchel
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Patent number: 6524831Abstract: The present invention relates to synthetic enzymes for the production of coniferyl alcohol, coniferylaldehyde, ferulic acid, vanillin and vanillic acid, the use thereof for the production of coniferyl alcohol, coniferylaldehyde, ferulic acid, vanillin and vanillic acid, DNA coding for these enzymes and microorganisms transformed with this DNA.Type: GrantFiled: November 21, 1997Date of Patent: February 25, 2003Assignee: Haarmann & Reimer GmbHInventors: Alexander Steinbüchel, Horst Priefert, Jürgen Rabenhorst
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Patent number: RE37543Abstract: A genomic fragment harboring the gene phaG was cloned by phenotype complementation of Pseudomonas putida KT2440 mutants, defective in the polyhydroxyalkanoic acid (PHA) synthesis via de novo fatty acid biosynthesis but not affected in PHA biosynthesis via fatty acid &bgr;-oxidation. The 885-bp phaG gene encodes a protein of 295 amino acids with a molecular weight of 33.876 Da. The transcriptional induction of phaG could be observed under conditions of PHA synthesis via de novo fatty acid biosynthesis whereas no induction was detected under conditions which favor PHA synthesis via fatty acid degradation by &bgr;-oxidation. The phaG gene is useful for the production of PHAs in bacteria and plants.Type: GrantFiled: May 12, 2000Date of Patent: February 5, 2002Assignee: Monsanto CompanyInventors: Niels Krüger, Alexander Steinbüchel