Patents by Inventor Alexander Steinbuchel
Alexander Steinbuchel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10889839Abstract: Nonnaturally occurring organisms exhibiting improved carbon utilization and methods for production and use of these nonnaturally occurring organisms in chemical production from carbon containing feedstocks are provided.Type: GrantFiled: November 15, 2019Date of Patent: January 12, 2021Assignee: INVISTA North America S.a.r.l.Inventors: Alexander Steinbüchel, Jessica Eggers, Alexander Brett Foster, Jonathan Kennedy
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Publication number: 20200157582Abstract: Nonnaturally occurring organisms exhibiting improved carbon utilization and methods for production and use of these nonnaturally occurring organisms in chemical production from carbon containing feedstocks are provided.Type: ApplicationFiled: November 15, 2019Publication date: May 21, 2020Applicant: INVISTA NORTH AMERICA S.A.R.L.Inventors: Alexander STEINBÜCHEL, Jessica EGGERS, Alexander Brett FOSTER, Jonathan KENNEDY
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Patent number: 9877996Abstract: The present invention relates to a process for the enzymatic production of a dipeptide composition from a cyanophycin (CGP) or CGP-like polymer preparation by degrading the polymer preparation with an CGPase, a CGPase particularly adapted for said process, and the use of cyanophycin (CGP) or CGP-like polymers or fragments thereof, notably a dipeptide composition obtained by the process as defined above, as pharmaceutical composition, medicament, or as food or feed substitute.Type: GrantFiled: February 11, 2015Date of Patent: January 30, 2018Assignee: WESTFÄLISCHE WILHELMS-UNIVERSITÄT MÜNSTERInventors: Ahmed Sallam, Alexander Steinbüchel
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Patent number: 9708593Abstract: This invention relates to cells and methods for producing lipids using cellulosic carbon source. More specifically the invention relates to oleaginous bacterial cells, wherein genes encoding at least one cellulolytic activity has been introduced. This invention also relates to methods for lipid production by cultivating an oleaginous bacterial strain or strains capable of expressing one or more cellulolytic activity.Type: GrantFiled: October 16, 2013Date of Patent: July 18, 2017Assignee: Neste OyjInventors: Stephan Hetzler, Stefan Uthoff, Daniel Broker, Alexander Steinbuchel, Perttu Koskinen
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Patent number: 9567618Abstract: The present invention is concerned with methods for producing vanillin, feroyl-CoA, ferulic acid, coniferyl aldehyde and/or coniferyl alcohol. Also, the invention relates to microorganisms useful in such production method, and to the construction of such microorganisms.Type: GrantFiled: June 18, 2012Date of Patent: February 14, 2017Assignee: SYMRISE AGInventors: Stefan Lambrecht, Jens-Michael Hilmer, Manuel Pesaro, Jens Kroll, Gunda Hansen, Alexander Steinbüchel, Christian Fleige
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Publication number: 20150322417Abstract: This invention relates to cells and methods for producing lipids using cellulosic carbon source. More specifically the invention relates to oleaginous bacterial cells, wherein genes encoding at least one cellulolytic activity has been introduced. This invention also relates to methods for lipid production by cultivating an oleaginous bacterial strain or strains capable of expressing one or more cellulolytic activity.Type: ApplicationFiled: October 16, 2013Publication date: November 12, 2015Applicant: Neste Oil OyjInventors: Stephan Hetzler, Stefan Uthoff, Daniel Broker, Alexander Steinbuchel, Perttu Koskinen
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Publication number: 20150231194Abstract: The present invention relates to a process for the enzymatic production of a dipeptide composition from a cyanophycin (CGP) or CGP-like polymer preparation by degrading the polymer preparation with an CGPase, a CGPase particularly adapted for said process, and the use of cyanophycin (CGP) or CGP-like polymers or fragments thereof, notably a dipeptide composition obtained by the process as defined above, as pharmaceutical composition, medicament, or as food or feed substitute.Type: ApplicationFiled: February 11, 2015Publication date: August 20, 2015Applicant: WESTFÄLISCHE WILHELMS-UNIVERSITÄT MÜNSTERInventors: Ahmed SALLAM, Alexander Steinbüchel
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Patent number: 8986960Abstract: Disclosed are microorganisms of the genus Cupriavidus or Ralstonia, which are genetically modified to express phosphomannose isomerase (EC5.3.1.8) and facilitated diffusion protein (EC1.3.1.74) for mannose uptake, and optionally mannofructokinase (EC2.7.1.4). The microorganisms also may be genetically modified to express xylose isomerase (EC 5.3.1.5), xylulokinase (E 2.7.1.17) and xylose proton symporter E or a high affinity ABC-transporter. The genetically modified microorganisms are capable of growing on mannose, xylose, arabinose, glucose, or galactose, or a combination thereof as the carbon source.Type: GrantFiled: July 15, 2011Date of Patent: March 24, 2015Assignee: Neste Oil OyjInventors: Shanna Sichwart, Birgit Haschenhermes, Daniel Bröker, Alexander Steinbüchel, Stephan Hetzler, Perttu Koskinen
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Patent number: 8980845Abstract: The present invention relates to a process for the enzymatic production of a dipeptide composition from a cyanophycin (CGP) or CGP-like polymer preparation by degrading the polymer preparation with an CGPase, a CGPase particularly adapted for said process, and the use of cyanophycin (CGP) or CGP-like polymers or fragments thereof, notably a dipeptide composition obtained by the process as defined above, as pharmaceutical composition, medicament, or as food or feed substitute.Type: GrantFiled: June 15, 2009Date of Patent: March 17, 2015Assignee: Westfälische Wilhelms-Universität MünsterInventors: Ahmed Sallam, Alexander Steinbüchel
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Publication number: 20140087428Abstract: The present invention is concerned with methods for producing vanillin, feroyl-CoA, ferulic acid, coniferyl aldehyde and/or coniferyl alcohol. Also, the invention relates to microorganisms useful in such production method, and to the construction of such microorganisms.Type: ApplicationFiled: June 18, 2012Publication date: March 27, 2014Inventors: Stefan Lambrecht, Jens-Michael Hilmer, Manuel Pesaro, Jens Kroll, Gunda Hansen, Alexander Steinbüchel, Christian Fleige
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Publication number: 20120015413Abstract: The present invention relates to a microorganism of the genus Cupriavidus or Ralstonia, which is genetically modified to express phosphomannose isomerase (EC5.3.1.8) and facilitated diffusion protein for mannose uptake (EC1.3.1.74), and optionally mannofructokinase (EC2.7.1.4) and/or xylose isomerase (EC 5.3.1.5), xylulokinase (E 2.7.1.17) and xylose proton symporter E or a high affinity ABC-transporter. A modified Cupriavidus or Ralstonia host is capable of growing on mannose, xylose, arabinose, glucose, or galactose, or a combination thereof as the carbon source.Type: ApplicationFiled: July 15, 2011Publication date: January 19, 2012Applicant: NESTE OIL OYJInventors: Shanna Sichwart, Birgit Haschenhermes, Daniel Bröker, Alexander Steinbüchel, Stephan Hetzler, Perttu Koskinen
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Patent number: 7968325Abstract: Coexpression of a polyhydroxyalkanoic acid synthase and a either a fatty acid:acyl-CoA transferase or an acyl-CoA synthetase in cells enables the biosynthesis of polyester materials. Plasmids, bacteria, materials, and methods for the preparation of polyesters are disclosed.Type: GrantFiled: June 14, 2004Date of Patent: June 28, 2011Assignee: Metabolix, Inc.Inventors: Silke Hein, Brigitte Sohling, Gerhard Gottschalk, Alexander Steinbuchel
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Publication number: 20110118177Abstract: The present invention relates to a process for the enzymatic production of a dipeptide composition from a cyanophycin (CGP) or CGP-like polymer preparation by degrading the polymer preparation with an CGPase, a CGPase particularly adapted for said process, and the use of cyanophycin (CGP) or CGP-like polymers or fragments thereof, notably a dipeptide composition obtained by the process as defined above, as pharmaceutical composition, medicament, or as food or feed substitute.Type: ApplicationFiled: June 15, 2009Publication date: May 19, 2011Inventors: Ahmed Sallam, Alexander Steinbüchel
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Publication number: 20090203093Abstract: The present invention relates to a method of targeting a protein of interest to an intracellular hydrophobic inclusion body of a bacterial cell by means of a fusion protein comprising a hydrophobic targeting peptide operatively linked with said protein of interest; methods of microbial production of a lipophilic compound of interest by means of a recombinant bacterial host comprising intracellular inclusion bodies having at least one enzyme which is involved in the biosynthesis of said lipophilic compound targeted to said inclusion bodies; as well as corresponding fusion proteins, coding sequences, expression vectors and recombinant hosts.Type: ApplicationFiled: July 10, 2007Publication date: August 13, 2009Applicant: BASF SEInventors: Alexander Steinbüchel, Marc Wältermann, Jan Hänisch
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Publication number: 20090036576Abstract: The present invention relates to fermentation processes for the production of cyanophycin in a microorganism whereby a plant-derived nitrogen source is converted by the microorganism into cyanophycin. The plant-derived nitrogen source preferably is a process stream being obtained in the processing of agricultural crops such as e.g., a by-product in the processing of starch from agricultural crops like corn, potato or cassave. The invention further relates to processes for the conversion of cyanophycin into a variety of compounds including e.g., ornithine, 1,4-butanediamine, n-alkyl amino alcohols, acrylonitrile, as well as cyanophycin derived functionalised poly(aspartic acid)s wherein the arginine residues have been functionalised to ornithine, (N-L-arginino)succinate, N-phospho-L-arginine or agmantine and the lysine residues have been functionalised to N6-hydroxy-L-lysine, 2,5-diaminohexanoate, N6-(L-1,3-dicarboxypropyl), pentanediamine, 5-aminopentanamide or N6-acetyl-L-lysine.Type: ApplicationFiled: March 6, 2006Publication date: February 5, 2009Inventors: Yasser Abdel Kader Elbahloul, Elinor Lindsey Scott, Andreas Mooibroek, Johan Pieter Marinus Sanders, Martin Obst, Alexander Steinbuchel
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Patent number: 7118896Abstract: The invention provides polypeptides having wax ester synthase and acyl-CoA:diacylglycerol acyltransferase activity. Also provided are the nucleic acids encoding such polypeptides, cells and organisms transformed therewith and methods of use thereof. The invention allows the modification of lipid profiles in host cells and organisms. Novel methods for the production of waxy esters are also provided by the invention.Type: GrantFiled: March 3, 2003Date of Patent: October 10, 2006Assignee: Monsanto Technology, L.L.C.Inventors: Rainer Kalscheuer, Alexander Steinbuchel, Toni Voelker
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Publication number: 20040253693Abstract: Coexpression of a polyhydroxyalkanoic acid synthase and a either a fatty acid:acyl-CoA transferase or an acyl-CoA synthetase in cells enables the biosynthesis of polyester materials. Plasmids, bacteria, materials, and methods for the preparation of polyesters are disclosed.Type: ApplicationFiled: June 14, 2004Publication date: December 16, 2004Applicant: Metabolix, Inc.Inventors: Silke Hein, Brigitte Sohling, Gerhard Gottschalk, Alexander Steinbuchel
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Publication number: 20040203123Abstract: The invention relates to a method for the transformation of Amycolatopsis sp. DSM 9991 and DSM 9992 and the use of the strains transformed in this way for the preparation of vanillin, preferably for the preparation of vanillin from ferulic acid.Type: ApplicationFiled: March 10, 2004Publication date: October 14, 2004Applicant: Symrise GmbH & Co. KG.Inventors: Jurgen Rabenhorst, Alexander Steinbuchel, Horst Priefert, Sandra Achterhold
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Patent number: 6770464Abstract: The present invention relates to a process for the production of poly (hydroxy fatty acids) as well as recombinant bacterial strains for carrying out the process. In addition, new poly(hydroxy fatty acids) and new substrates for the production of conventional and new poly(hydroxy fatty acids) are described. Moreover, the invention also relates to a DNA fragment, which codes for a PhaE and a PhaC component of the poly(hydroxy fatty acid) synthase from Thiocapsa pfennigii, as well as the corresponding poly (hydroxy fatty acid) synthase protein.Type: GrantFiled: February 8, 2001Date of Patent: August 3, 2004Assignee: Metabolix, Inc.Inventors: Alexander Steinbüchel, Mathias Liebergesell, Henry Valentin, Andreas Pries
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Patent number: 6759219Abstract: Coexpression of a polyhydroxyalkanoic acid synthase and either a fatty acid: acyl-CoA transferase or an acyl-CoA synthetase in cells enables the biosynthesis of polyester materials. Plasmids, bacteria, materials, and methods for the preparation of polyesters are disclosed.Type: GrantFiled: September 3, 1999Date of Patent: July 6, 2004Assignee: Metabolix, Inc.Inventors: Silke Hein, Brigitte Söhling, Gerhard Gottschalk, Alexander Steinbüchel