Abstract: The invention relates to a device for producing and inhaling smoke, in particular to e-cigarettes for producing and inhaling smoke, comprising at least two chambers that are each designed and intended for receiving a smoking product, for example tobacco or a liquid to be vaporised. The device further comprises at least one means for receiving smoke formed inside the chambers, the means being fluidically connected to the two chambers and also to a mouthpiece for inhaling the smoke. In this case, the means for receiving smoke comprises at least one adjustment mechanism, a through-flow cross section with respect to each chamber and/or with respect to the mouthpiece being adjustable by means of the adjustment mechanism. As a result, either, one of the two smoking products can be inhaled by a user as desired, or both smoking products can be inhaled at the same time.

Abstract: Provided herein are antibodies that selectively bind to Tim-3 and its isoforms and homologs, and compositions comprising the antibodies. Also provided herein are antibodies that selectively bind to PD-1 and its isoforms and homologs, and compositions comprising the antibodies. In addition, provided herein are bi-specific antibodies and antigen binding constructs that selectively bind to Tim-3 and/or PD-1, their isoforms and homologs, and compositions comprising the antibodies and antigen binding constructs. Also provided are methods of using the antibodies, such as therapeutic and diagnostic methods.

Abstract: Provided herein are antibodies that selectively bind to LAG3 and its isoforms and homologs, and compositions comprising the antibodies. Also provided herein are antibodies that selectively bind to PD-1 and its isoforms and homologs, and compositions comprising the antibodies. In addition, provided herein are bi-specific antibodies and antigen binding constructs that selectively bind to LAG3 and/or PD-1, their isoforms and homologs, and compositions comprising the antibodies and antigen binding constructs. Also provided are methods of using the antibodies, such as therapeutic and diagnostic methods.

Abstract: This invention provides high growth capacity strains of auxotrophic Escherichia coli and methods for generating thereof. The high growth capacity strains express a complementing auxotrophic plasmid that allows the strain to grow in the absence of the auxotrophic amino acid. Also, provided herein is a method for preparing a bacterial cell extract of a high growth capacity strain of auxotrophic Escherichia coli for use in an in vitro protein expression.

Abstract: The invention relates to a device for producing and inhaling smoke, in particular to e-cigarettes for producing and inhaling smoke, comprising at least two chambers that are each designed and intended for receiving a smoking product, for example tobacco or a liquid to be vaporised. The device further comprises at least one means for receiving smoke formed inside the chambers, the means being fluidically connected to the two chambers and also to a mouthpiece for inhaling the smoke. In this case, the means for receiving smoke comprises at least one adjustment mechanism, a through-flow cross section with respect to each chamber and/or with respect to the mouthpiece being adjustable by means of the adjustment mechanism. As a result, either, one of the two smoking products can be inhaled by a user as desired, or both smoking products can be inhaled at the same time.

Abstract: This invention provides high growth capacity strains of auxotrophic Escherichia coli and methods for generating thereof. The high growth capacity strains express a complementing auxotrophic plasmid that allows the strain to grow in the absence of the auxotrophic amino acid. Also, provided herein is a method for preparing a bacterial cell extract of a high growth capacity strain of auxotrophic Escherichia coli for use in an in vitro protein expression.

Abstract: This invention provides high growth capacity strains of auxotrophic Escherichia coli and methods for generating thereof. The high growth capacity strains express a complementing auxotrophic plasmid that allows the strain to grow in the absence of the auxotrophic amino acid. Also, provided herein is a method for preparing a bacterial cell extract of a high growth capacity strain of auxotrophic Escherichia coli for use in an in vitro protein expression.