Abstract: Methods and apparatus for identifying and evaluating surgical stereotactic trajectories to a target area are disclosed. Entry points and trajectories are evaluated based on segmented images. The segmentation process may involve segmenting the anatomical region into discrete regions. Candidate entry points are evaluated according to image intensity following segmentation of the anatomical region. Candidate entry points may be refined according to various angle corridors. Following identification of a target area, for each candidate entry point, the proposed trajectory is evaluated using segmented image data (e.g., identifying tissue types) and image intensity. The final proposed trajectory is based on derivation of a statistic for each trajectory indicating the deviation at each point from the mean region of interest image intensity and selection of trajectory with the lowest statistic value. The proposed trajectory is then presented to a computer user.