Abstract: A system can include one or more processors; memory; a data interface that receives data; a control interface that transmits control signals for control of pumps of a hydraulic fracturing operation; and one or more components that can include one or more of a modeling component that predicts pressure in a well fluidly coupled to at least one of the pumps, a pumping rate adjustment component that generates a pumping rate control signal for transmission via the control interface, a capacity component that estimates a real-time pumping capacity for each individual pump, and a control component that, for a target pumping rate for the pumps during the hydraulic fracturing operation, generates at least one of engine throttle and transmission gear settings for each of the individual pumps using an estimated real-time pumping capacity for each individual pump where the settings are transmissible via the control interface.

Abstract: The present invention relates to methods of producing a food or malt-based beverage suitable for consumption by a subject with Coeliac's disease. In particular, the present invention relates to methods of producing a food or malt-based beverage with very low levels of hordeins. Also provided are barley plants which produce grain that can be used in the methods of the invention.

Abstract: A system can include one or more processors; memory; a data interface that receives data; a control interface that transmits control signals for control of pumps of a hydraulic fracturing operation; and one or more components that can include one or more of a modeling component that predicts pressure in a well fluidly coupled to at least one of the pumps, a pumping rate adjustment component that generates a pumping rate control signal for transmission via the control interface, a capacity component that estimates a real-time pumping capacity for each individual pump, and a control component that, for a target pumping rate for the pumps during the hydraulic fracturing operation, generates at least one of engine throttle and transmission gear settings for each of the individual pumps using an estimated real-time pumping capacity for each individual pump where the settings are transmissible via the control interface.

Abstract: Changing a cumulative pumping rate of multiple pump units by adjusting individual pumping rates of the pump units, wherein each temporary dip or spike of an individual pumping rate of one of the pump units is automatically offset by a predetermined temporary adjustment of an individual pumping rate of another one or more of the pump units to thereby reduce effects of the temporary dip or spike on the cumulative pumping rate of the pump units.

Abstract: Systems and methods presented herein include a computing system that includes a non-transitory memory and one or more hardware processors configured to read instructions from the non-transitory memory to perform operations. The operations include detecting one or more pumps of a wellsite system that are activated. The operations also include generating a graphical user interface. The graphical user interface includes a pump list panel comprising one or more pump icons, each pump icon corresponding to a pump of the one or more pumps. The graphical user interface also includes a manifold layout panel comprising a manifold outline that represents an actual physical layout of one or more manifolds of the wellsite system. The operations also include receiving, via the graphical user interface, an input assigning a pump icon of the one or more pump icons onto a pump location of the manifold outline.

Abstract: Changing a cumulative pumping rate of multiple pump units by adjusting individual pumping rates of the pump units, wherein each temporary dip or spike of an individual pumping rate of one of the pump units is automatically offset by a predetermined temporary adjustment of an individual pumping rate of another one or more of the pump units to thereby reduce effects of the temporary dip or spike on the cumulative pumping rate of the pump units.

Abstract: The use of compositions including two or more cucurbiturils in counteracting malodour in a moist environment. The two or more cucurbiturils are selected from CB[5], CB [6], CB [7] and CB[8]. Also provided is a method for counteracting malodour in a moist environment, including application of a composition including a mixture of two or more cucurbiturils selected from CB[5], CB[6], CB[7] and CB[8].

Abstract: Systems and methods presented herein include a computing system that includes a non-transitory memory and one or more hardware processors configured to read instructions from the non-transitory memory to perform operations. The operations include detecting one or more pumps of a wellsite system that are activated. The operations also include generating a graphical user interface. The graphical user interface includes a pump list panel comprising one or more pump icons, each pump icon corresponding to a pump of the one or more pumps. The graphical user interface also includes a manifold layout panel comprising a manifold outline that represents an actual physical layout of one or more manifolds of the wellsite system. The operations also include receiving, via the graphical user interface, an input assigning a pump icon of the one or more pump icons onto a pump location of the manifold outline.

Abstract: Methods and systems pertaining to generating a startup or other operating order of pumps of a pumping system for performing a subterranean formation fracturing operation, and/or another pumping operation, and for coordinating distribution of flow rates to the pumps for performing the pumping operation.

Abstract: Provided herein are compositions and methods involving nucleic acid nanostructures that can encapsulate cargo for use in, for example, therapeutic, diagnostic, and analytical applications. The nanostructures can have a plurality of interconnected subunits configured such that the nanostructures have a continuous torus-like structure with a closed three-dimensional cavity. Preferably, the nanostructure is a nucleic acid mazzocchio. The subunits are connected by linkers having defined lengths to constrain the nanostructure into the continuous torus-like shape. The closed three-dimensional cavity is of defined size to encapsulate any cargo of interest. Cargo can also be positioned in the open hole at the center of the nanostructure. The cargo can be a wide range of compounds including, for example, chemical drugs, small molecules, therapeutics, targeting agents, enzymes, dyes, and fluorescent molecules.

Abstract: A system can include one or more processors; memory; a data interface that receives data; a control interface that transmits control signals for control of pumps of a hydraulic fracturing operation; and one or more components that can include one or more of a modeling component that predicts pressure in a well fluidly coupled to at least one of the pumps, a pumping rate adjustment component that generates a pumping rate control signal for transmission via the control interface, a capacity component that estimates a real-time pumping capacity for each individual pump, and a control component that, for a target pumping rate for the pumps during the hydraulic fracturing operation, generates at least one of engine throttle and transmission gear settings for each of the individual pumps using an estimated real-time pumping capacity for each individual pump where the settings are transmissible via the control interface.

Abstract: Changing a cumulative pumping rate of multiple pump units by adjusting individual pumping rates of the pump units, wherein each temporary dip or spike of an individual pumping rate of one of the pump units is automatically offset by a predetermined temporary adjustment of an individual pumping rate of another one or more of the pump units to thereby reduce effects of the temporary dip or spike on the cumulative pumping rate of the pump units.

Abstract: Methods and systems pertaining to generating a startup or other operating order of pumps of a pumping system for performing a subterranean formation fracturing operation, and/or another pumping operation, and for coordinating distribution of flow rates to the pumps for performing the pumping operation.

Abstract: A pro-fragrance composition includes a cucurbituril in complex with a fragrance molecule and use of the compositions in counteracting malodour. The cucurbituril is present as a mixture, wherein the mixture includes at least two different cucurbiturils selected from CB[5], CB[6], CB[7] and CB[8]. The complexed fragrance molecule is released when the composition is exposed to a stimulus. Also provides methods for the preparation of pro-fragrance complexes of cucurbiturils and fragrance molecules.

Abstract: A pro-fragrance composition includes a cucurbituril in complex with a fragrance molecule and use of the compositions in counteracting malodour. The cucurbituril is present as a mixture, wherein the mixture includes at least two different cucurbiturils selected from CB[5], CB[6], CB[7] and CB[8]. The complexed fragrance molecule is released when the composition is exposed to a stimulus. Also provides methods for the preparation of pro-fragrance complexes of cucurbiturils and fragrance molecules.

Abstract: The use of compositions including two or more cucurbiturils in counteracting malodour in a moist environment. The two or more cucurbiturils are selected from CB[5], CB [6], CB [7] and CB[8]. Also provided is a method for counteracting malodour in a moist environment, including application of a composition including a mixture of two or more cucurbiturils selected from CB[5], CB[6], CB[7] and CB[8].

Abstract: Described herein is a method that displays RNA on the DNA from which it was encoded, enabling enhanced selection of RNA aptamers and proteins. The covalent link between RNA and the DNA which encodes it can be used to negate the spatial informational loss following transcription. This method has applications in the selection of binding ligands such as RNA aptamers and antibodies as well as catalytic molecules such as aptazymes and enzymes.

Abstract: Described are nucleic acid aptamers that are able to bind to and inhibit the function of sclerostin, which is an important negative regulator of bone growth. The aptamers have application as therapeutics for diseases of bone including osteoporosis, osteopenia, osteoarthritis and other osteoporosis-related conditions and complications.

Abstract: Described are nucleic acid aptamers that are able to bind to and inhibit the function of sclerostin, which is an important negative regulator of bone growth. The aptamers have application as therapeutics for diseases of bone including osteoporosis, osteopenia, osteoarthritis and other osteoporosis-related conditions and complications.