Abstract: The invention relates to an application system for the transepidermal surface administration of medications, said system comprising a container (1) accommodating a sprayable, active agent-containing composition, a propellant gas source (3) for pressurized gas consisting of at least 25% v/v of oxygen, and a spraying device (2), wherein container (1), propellant gas source (3), and spraying device (2) are flow-connected with each other in such a manner that the propellant gas atomizes the sprayable composition and, when the spraying device (2) is actuated, forces it out of the spraying device (2), with the composition being forced out of the spraying device (2) in the form of a conical spray jet at an exit velocity of ?100 m/s. With the help of the inventive application system active agents can be effectively administered via the skin without causing injury to the skin. As a result of the high exit velocity the penetration rate is especially favorable even when larger molecules are introduced.

Abstract: The invention relates to an application system for the transepidermal surface administration of medications, said system comprising a container (1) accommodating a sprayable, active agent-containing composition, a propellant gas source (3) for pressurized gas consisting of at least 25% v/v of oxygen, and a spraying device (2), wherein container (1), propellant gas source (3), and spraying device (2) are flow-connected with each other in such a manner that the propellant gas atomizes the sprayable composition and, when the spraying device (2) is actuated, forces it out of the spraying device (2), with the composition being forced out of the spraying device (2) in the form of a conical spray jet at an exit velocity of ?100 m/s. With the help of the inventive application system active agents can be effectively administered via the skin without causing injury to the skin. As a result of the high exit velocity the penetration rate is especially favorable even when larger molecules are introduced.

Abstract: The present invention relates to biocompatible microemulsions based on honey which can additionally comprise both water-soluble and also fat-soluble active ingredients in stable form. Via the microemulsion bioavailable nutrients bonded in the honey, preferably together with further active substances, are introduced by topical application into the skin or orally, nasally or percutaneously into the body where they develop their positive effects. These emulsions can be prepared easily and are used both in medicine/veterinary medicine, dermatology and also in cosmetics. Moreover, the honey microemulsions can be used on their own or with nutritionally relevant substances in the fields of foodstuff, functional foods, food supplements or dietetic products.

Abstract: The invention relates to therapeutically active wound dressings based on polysaccharides, in particular chitosan, and protein, in particular collagen/gelatine, with improved properties, their manufacture, in particular the use of polycarbonic acids and polyfunctional amino acids, and their use, especially in the medical field.

Abstract: Micro-emulsions having a binary phase differentiability and active substance differentiability, the production thereof, and their use, particularly for the topical supply of oxygen The present invention relates to skin-compatible micro-emulsions that are suitable for the treatment of hair and skin, based on a primary W/O micro-emulsions that are converted into both a secondary W/O and into a secondary O/W micro-emulsion, and can contain, in particular, both water-soluble and fat-soluble active substances in stable form. Preferably, the emulsion contains an oxygen binder such as hemoglobin, with which bound bioavailable oxygen, preferably together with other active substances, can be introduced into the skin by means of topical application, in order to support the cell growth of the stratum germinativum. These emulsions can be produced easily, without great technical effort, and can be used both in cosmetics and in medicine (dermatology).

Abstract: The present invention relates to the use of one or more natural or modified oxygen carriers, devoid of plasma or cellular membrane constituents, for the production of an agent for the external treatment of open wounds, particularly chronic wounds. Hemoglobin or myoglobin of human or animal origin are suitable as oxygen carriers. The oxygen carriers can also preferably be modified. Suitable modifications are cross-linking, reaction with polyalkylene oxides, chemically reactive or chemically non-reactive effectors, or combinations. The agent is applied to the wound area particularly by means of spraying on an aqueous solution containing the oxygen carrier(s). The oxygen carriers can be used in particularly effective manner in the case of chronic wounds resulting from tissue degeneration, particularly diabetic tissue degeneration.

Abstract: A process for the preparation of chitosan-glucan complexes from biological sources by treating said biological sources with solutions, characterized in that a) chitin-containing microorganisms as said biological sources are treated at least once with a first alkaline solution; b) thereafter, the product obtained from step a) is treated with diluted mineral acid; c) followed by a further treatment with a second alkaline solution the alkalinity of which is higher than that of the alkaline solution of step a) to incomplete deacetylation of the fraction obtained step b); d) separating the solid components, discarding the supernatant, neutralizing and washing the residue with water.