Abstract: Disclosed herein are systems and methods for coupling electrodes to electrical components that may be utilized in a variety of applications to collect data from the electrodes. In one embodiment, an electrode connection system to couple an electrode to an electrical component. The electrode connection system includes the electrical connector body comprising a PCB assembly cavity and an electrode channel. An electrode clamp coupled to the electrical connector body may include an engaging mechanism and at least one electrode clamp pad protrusion to couple an at least one electrode pad to an at least one connector pad. The PCB assembly may include at least one connector pad. The electrode may comprise at least one electrically active electrode pad. The electrical component may collect data from the electrode or stimulate tissue utilizing the electrode.