Abstract: The present invention relates to divalent compounds binding to LecA. The compounds are useful to block biofilm formation of Pseudomonas aeruginosa. The invention further relates to pharmaceutical compositions comprising these compounds and to therapeutic methods and uses of these compounds, in particular to therapeutic methods and uses for the treatment of Pseudomonas aeruginosa infections in a subject. The invention also relates to imaging of infections, such as biofilms produced by Pseudomonas aeruginosa, by using these divalent compounds.

Abstract: The present invention relates to divalent compounds binding to LecA. The compounds are useful to block biofilm formation of Pseudomonas aeruginosa. The invention further relates to pharmaceutical compositions comprising these compounds and to therapeutic methods and uses of these compounds, in particular to therapeutic methods and uses for the treatment of Pseudomonas aeruginosa infections in a subject. The invention also relates to imaging of infections, such as biofilms produced by Pseudomonas aeruginosa, by using these divalent compounds.

Abstract: An actuator module for releasing an equipment component comprising a module base forming a guide sleeve, a release body for coupling to the equipment component and inserted into the guide sleeve, which release body is movable relative to the guide sleeve along a sleeve axis thereof from a standby position to a working position, a blocking body mounted on the guide sleeve, which, in its blocking position, blocks the release body against movement out of the standby position into the working position and, in its release position, allows movement of the release body from the standby position into the working position, and an actuator unit for moving the blocking body from the blocking position to the release position, the actuator unit comprising at least one actuator wire of shape memory material secured with wire ends to the module base and coupled to the blocking body for applying an activating force.

Abstract: The present invention relates to a conjugate comprising a ligand specifically binding to a bacterial lectin, a linker comprising a peptide cleavable by a bacterial protease, and an anti-bacterial therapeutic agent or imaging agent. It further relates to the conjugate or the pharmaceutical composition or diagnostic composition for use in medicine.

Abstract: Described is an actuator module (100; 200; 300; 400) for releasing an equipment component, e.g.

Abstract: The present invention relates to divalent compounds binding to LecA. The compounds are useful to block biofilm formation of Pseudomonas aeruginosa. The invention further relates to pharmaceutical compositions comprising these compounds and to therapeutic methods and uses of these compounds, in particular to therapeutic methods and uses for the treatment of Pseudomonas aeruginosa infections in a subject. The invention also relates to imaging of infections, such as biofilms produced by Pseudomonas aeruginosa, by using these divalent compounds.

Abstract: The present invention relates to compounds derived from deoxy fucose. These compounds are useful as lectin inhibitors, especially as inhibitors of LecB. The invention also relates to pharmaceutical compositions comprising these compounds. The invention further relates to therapeutic uses of these compounds, especially to the prophylaxis or treatment of infections involving Pseudomonas aeruginosa.

Abstract: The present invention relates to compounds derived from deoxy fucose. These compounds are useful as lectin inhibitors, especially as inhibitors of LecB. The invention also relates to pharmaceutical compositions comprising these compounds. The invention further relates to therapeutic uses of these compounds, especially to the prophylaxis or treatment of infections involving Pseudomonas aeruginosa.

Abstract: A device for turning over an object, particularly a package of stacked sacks, having a holder device for the purpose of receiving, turning over, and releasing the object, the holder device including two transport elements for conveying the object, and having a rotary device for rotating the transport elements about a stationary axis of rotation, the rotary device including a rotatable frame to fasten the transport elements on both sides thereof, where the transport elements are fastened to the frame in a manner allowing movement, where the rotary device has a rotary drive which drives the frame on both sides.

Abstract: The present invention relates to fucose- and mannose-derived glycomimetics and their general use in prophylaxis or treatment of Pseudomonas aeruginosa infections including respiratory tract infections, urinary tract infections, nosocomial infections and chronic wound infections in a patient encompassing a patient suffering already from cystic fibrosis. Said glycomimetics are inhibitors of Pseudomonas aeruginosa lectin LecB.

Abstract: A device for turning over an object, particularly a package of stacked sacks, having a holder device for receiving, turning over, and releasing the object, the holder device including two transport elements for conveying the object, and including at least one transport drive for the purpose of driving the transport elements, and having a rotary device for rotating the transport elements about a stationary axis of rotation, the rotary device including a rotatable frame to fasten the transport elements on both sides thereof, wherein the transport elements are fastened to the frame in a manner allowing movement, and wherein the transport drive is fastened in a torque-proof manner to the frame.

Abstract: The present invention relates to fucose- and mannose-derived glycomimetics and their general use in prophylaxis or treatment of Pseudomonas aeruginosa infections including respiratory tract infections, urinary tract infections, nosocomial infections and chronic wound infections in a patient encompassing a patient suffering already from cystic fibrosis. Said glycomimetics are inhibitors of Pseudomonas aeruginosa lectin LecB.

Abstract: A device for turning over an object, particularly a package of stacked sacks, having a holder device for receiving, turning over, and releasing the object, the holder device including two transport elements for conveying the object, and including at least one transport drive for the purpose of driving the transport elements, and having a rotary device for rotating the transport elements about a stationary axis of rotation, the rotary device comprising including a rotatable frame to fasten the transport elements on both sides thereof, wherein the transport elements are fastened to the frame in a manner allowing movement, and wherein the transport drive is fastened in a torque-proof manner to the frame.

Abstract: A device for turning over an object, particularly a package of stacked sacks, having a holder device for the purpose of receiving, turning over, and releasing the object, the holder device including two transport elements for conveying the object, and having a rotary device for rotating the transport elements about a stationary axis of rotation, the rotary device including a rotatable frame to fasten the transport elements on both sides thereof, wherein the transport elements are fastened to the frame in a manner allowing movement, where the rotary device has a rotary drive which drives the frame on both sides.