Patents by Inventor Alexander V. Kelin

Alexander V. Kelin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • OLIGONUCLEOTIDE-LIGAND CONJUGATES AND PROCESS FOR THEIR PREPARATION
    Publication number: 20220348914
    Abstract: The present invention relates to ligand conjugates of oligonucleotides (e.g., iRNA agents) and methods for their preparation. The ligands are derived primarily from monosaccharides These conjugates are useful for the in vivo delivery of oligonucleotides.
    Type: Application
    Filed: October 2, 2020
    Publication date: November 3, 2022
    Inventors: Muthiah Manoharan, Jayaprakash K. Nair, Pachamuthu Kandasamy, Shigeo Matsuda, Alexander V. Kelin, Muthusamy Jayaraman, Kallanthottathil G. Rajeev
  • Oligonucleotide-ligand conjugates and process for their preparation
    Patent number: 10808246
    Abstract: The present invention relates to ligand conjugates of iRNA agents (such as siRNA) of the formula
    Type: Grant
    Filed: July 11, 2014
    Date of Patent: October 20, 2020
    Assignee: ALNYLAM PHARMACEUTICALS, INC.
    Inventors: Muthiah Manoharan, Jayaprakash K. Nair, Pachamuthu Kandasamy, Shigeo Matsuda, Alexander V. Kelin, Muthusamy Jayaraman, Kallanthottathil G. Rajeev
  • Carbohydrate conjugated RNA agents and process for their preparation
    Patent number: 10086081
    Abstract: This disclosure relates to an improved process for the preparation of carbohydrate conjugates. The disclosure also relates to carbohydrate conjugated iRNA agents comprising these carbohydrate conjugates, which have improved purity and are advantageous for the in vivo delivery of the iRNA agents.
    Type: Grant
    Filed: August 6, 2013
    Date of Patent: October 2, 2018
    Assignee: ALNYLAM PHARMACEUTICALS, INC.
    Inventors: Jayaprakash K. Nair, Alexander V. Kelin, Pachamuthu Kandasamy, Kallanthottathil G. Rajeev, Muthiah Manoharan
  • OLIGONUCLEOTIDE-LIGAND CONJUGATES AND PROCESS FOR THEIR PREPARATION
    Publication number: 20160376585
    Abstract: The present invention relates to ligand conjugates of oligonucleotides (e.g., iRNA agents) and methods for their preparation. The ligands are derived primarily from monosaccharides These conjugates are useful for the in vivo delivery of oligonucleotides.
    Type: Application
    Filed: July 11, 2014
    Publication date: December 29, 2016
    Inventors: Muthiah MANOHARAN, Jayaprakash K. NAIR, Pachamuthu KANDASAMY, Shigeo MATSUDA, Alexander V. KELIN, Muthusamy JAYARAMAN, Kallanthottathil G. RAJEEV
  • NUCLEIC ACID CHEMICAL MODIFICATIONS
    Publication number: 20160348110
    Abstract: The present invention provides nucleosides of formula (1) and oligonucleotides comprising at least on nucleoside of formula (2): Another aspect of the invention relates to a method of inhibiting the expression of a gene in cell, the method comprising (a) contacting an oligonucleotide of the invention with the cell; and (b) maintaining the cell from step (a) for a time sufficient to obtain degradation of the mRNA of the target gene.
    Type: Application
    Filed: August 11, 2016
    Publication date: December 1, 2016
    Inventors: Muthiah MANOHARAN, Kallanthottathil G. RAJEEV, Alexander V. KELIN, Sudhakar Rao TAKKELLAPATI, Shigeo MATSUDA
  • Nucleic acid chemical modifications
    Patent number: 9453043
    Abstract: The present invention provides nucleosides of formula (1) and oligonucleotides comprising at least one nucleoside of formula (2): Another aspect of the invention relates to a method of inhibiting the expression of a gene in cell, the method comprising (a) contacting an oligonucleotide of the invention with the cell; and (b) maintaining the cell from step (a) for a time sufficient to obtain degradation of the mRNA of the target gene.
    Type: Grant
    Filed: January 22, 2015
    Date of Patent: September 27, 2016
    Assignee: ALNYLAM PHARMACEUTICALS, INC.
    Inventors: Muthiah Manoharan, Kallanthottathil G. Rajeev, Alexander V. Kelin, Sudhakar Rao Takkellapati, Shigeo Matsuda
  • NUCLEIC ACID CHEMICAL MODIFICATIONS
    Publication number: 20150210733
    Abstract: The present invention provides nucleosides of formula (1) and oligonucleotides comprising at least on nucleoside of formula (2): Another aspect of the invention relates to a method of inhibiting the expression of a gene in cell, the method comprising (a) contacting an oligonucleotide of the invention with the cell; and (b) maintaining the cell from step (a) for a time sufficient to obtain degradation of the mRNA of the target gene.
    Type: Application
    Filed: January 22, 2015
    Publication date: July 30, 2015
    Inventors: Muthiah MANOHARAN, Kallanthottathil G. RAJEEV, Alexander V. KELIN, Sudhakar Rao TAKKELLAPATI, Shigeo MATSUDA
  • CARBOHYDRATE CONJUGATED RNA AGENTS AND PROCESS FOR THEIR PREPARATION
    Publication number: 20150196655
    Abstract: This disclosure relates to an improved process for the preparation of carbohydrate conjugates. The disclosure also relates to carbohydrate conjugated iRNA agents comprising these carbohydrate conjugates, which have improved purity and are advantageous for the in vivo delivery of the iRNA agents.
    Type: Application
    Filed: August 6, 2013
    Publication date: July 16, 2015
    Inventors: Jayaprakash K. Nair, Alexander V. Kelin, Pachamuthu Kandasamy, Kallanthottahill G. Rajeev, Muthiah Manoharan
  • Nucleic acid chemical modifications
    Patent number: 8975389
    Abstract: The present invention provides nucleosides of formula (1) and oligonucleotides comprising at least one nucleoside of formula (2): Another aspect of the invention relates to a method of inhibiting the expression of a gene in cell, the method comprising (a) contacting an oligonucleotide of the invention with the cell; and (b) maintaining the cell from step (a) for a time sufficient to obtain degradation of the mRNA of the target gene.
    Type: Grant
    Filed: March 2, 2010
    Date of Patent: March 10, 2015
    Assignee: Alnylam Pharmaceuticals, Inc.
    Inventors: Muthiah Manoharan, Kallanthottathil G. Rajeev, Alexander V. Kelin, Sudhakar Rao Takkellapati, Shigeo Matsuda
  • NUCLEIC ACID CHEMICAL MODIFICATIONS
    Publication number: 20120071641
    Abstract: The present invention provides nucleosides of formula (1) and oligonucleotides comprising at least one nucleoside of formula (2): Another aspect of the invention relates to a method of inhibiting the expression of a gene in cell, the method comprising (a) contacting an oligonucleotide of the invention with the cell; and (b) maintaining the cell from step (a) for a time sufficient to obtain degradation of the mRNA of the target gene.
    Type: Application
    Filed: March 2, 2010
    Publication date: March 22, 2012
    Applicant: ALNYLAM PHARMACEUTICALS, INC.
    Inventors: Muthiah Manoharan, Kallanthottathil G. Rajeev, Alexander V. Kelin, Sudhakar Rao Takkellapati, Shigeo Matsuda