Patents by Inventor Alexander Victor Muehldorf

Alexander Victor Muehldorf has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Carboxylic acid derivatives as IP antagonists
    Patent number: 7312230
    Abstract: This invention relates to compounds which are generally IP receptor antagonists and which are represented by Formula I: wherein: R1, R2, and R3 are each independently in each occurrence aryl or heteroaryl; R4 is —COOH or tetrazolyl; A, B, m, n, and r are as defined in the specification; or individual isomers, racemic or non-racemic mixtures of isomers, or pharmaceutically acceptable salts or solvates thereof. The invention further relates to pharmaceutical compositions containing such compounds, methods for their use as therapeutic agents, and processes for their preparation.
    Type: Grant
    Filed: September 30, 2005
    Date of Patent: December 25, 2007
    Assignee: Roche Palo Alto LLC
    Inventors: Richard Leo Cournoyer, Paul Francis Keitz, Lee Edwin Lowrie, Jr., Alexander Victor Muehldorf, Counde O'Yang, Dennis Mitsugu Yasuda
  • 2-(substituted-phenyl)amino-imidazoline derivatives
    Patent number: 7141584
    Abstract: This invention relates to IP receptor antagonists selected from the group of compounds represented by Formula I: where: R1 is a group represented by formula (A), (B) or (C); and other substituents as defined in the specification, and their pharmaceutically acceptable salts or crystal forms thereof; and pharmaceutical compositions containing them; and methods for their use as therapeutic agents.
    Type: Grant
    Filed: December 9, 2003
    Date of Patent: November 28, 2006
    Assignee: Roche Palo Alto LLC
    Inventors: Keith Roger Bley, Robin Douglas Clark, Alam Jahangir, Bruce Andrew Kowalczyk, Francisco Javier Lopez-Tapia, Alexander Victor Muehldorf, Counde O'Yang, Thomas Weitao Sun
  • Carboxylic acid derivatives as IP antagonists
    Patent number: 7056903
    Abstract: This invention relates to compounds which are generally IP receptor antagonists and which are represented by Formula I: wherein: R1, R2, and R3 are each independently in each occurrence aryl or heteroaryl; R4 is —COOH or tetrazolyl; A, B, m, n, and r are as defined in the specification; or individual isomers, racemic or non-racemic mixtures of isomers, or pharmaceutically acceptable salts or solvates thereof. The invention further relates to pharmaceutical compositions containing such compounds, methods for their use as therapeutic agents, and processes for their preparation.
    Type: Grant
    Filed: May 9, 2003
    Date of Patent: June 6, 2006
    Assignee: Syntex (U.S.A.) LLC
    Inventors: Richard Leo Cournoyer, Paul Francis Keitz, Lee Edwin Lowrie, Jr., Alexander Victor Muehldorf, Counde O'Yang, Dennis Mitsugu Yasuda
  • 2-(substituted-phenyl)amino-imidazoline derivatives
    Publication number: 20040122053
    Abstract: This invention relates to IP receptor antagonists selected from the group of compounds represented by Formula I: 1
    Type: Application
    Filed: December 9, 2003
    Publication date: June 24, 2004
    Inventors: Keith Roger Bley, Robin Douglas Clark, Alam Jahangir, Bruce Andrew Kowalczyk, Francisco Javier Lopez-Tapia, Alexander Victor Muehldorf, Counde O'Yang, Thomas Weitao Sun
  • 2-(substituted-phenyl)amino-imidazoline derivatives
    Patent number: 6693200
    Abstract: This invention relates to IP receptor antagonists selected from the group of compounds represented by Formula I: where: R1 is a group represented by formula (A), (B) or (C); and other substituents as defined in the specification, and their pharmaceutically acceptable salts or crystal forms thereof; and pharmaceutical compositions containing them; and methods for their use as therapeutic agents.
    Type: Grant
    Filed: April 29, 2003
    Date of Patent: February 17, 2004
    Assignee: Syntex (U.S.A.) LLC
    Inventors: Keith Roger Bley, Robin Douglas Clark, Alam Jahangir, Bruce Andrew Kowalczyk, Francisco Javier Lopez-Tapia, Alexander Victor Muehldorf, Counde O'Yang, Thomas Weitao Sun
  • Carboxylic acid derivatives as IP antagonists
    Patent number: 6693098
    Abstract: This invention relates to compounds which are generally IP receptor antagonists and which are represented by Formula I: wherein: R1, R2, and R3 are each independently in each occurrence aryl or heteroaryl; R4 is —COOH or tetrazolyl; A, B, m, n, and r are as defined in the specification; or individual isomers, racemic or non-racemic mixtures of isomers, or pharmaceutically acceptable salts or solvates thereof. The invention further relates to pharmaceutical compositions containing such compounds, methods for their use as therapeutic agents, and processes for their preparation.
    Type: Grant
    Filed: March 14, 2001
    Date of Patent: February 17, 2004
    Assignee: Syntex (U.S.A) LLC
    Inventors: Richard Leo Cournoyer, Paul Francis Keitz, Lee Edwin Lowrie, Jr., Alexander Victor Muehldorf, Counde O'Yang, Dennis Mitsugu Yasuda
  • 2-(Substituted-phenyl)amino-imidazoline derivatives
    Publication number: 20030229123
    Abstract: This invention relates to IP receptor antagonists selected from the group of compounds represented by Formula I: 1
    Type: Application
    Filed: April 29, 2003
    Publication date: December 11, 2003
    Inventors: Keith Roger Bley, Robin Douglas Clark, Alam Jahangir, Bruce Andrew Kowalczyk, Francisco Javier Lopez-Tapia, Alexander Victor Muehldorf, Counde O'Yang, Thomas Weitao Sun
  • Carboxylic acid derivatives as IP antagonists
    Publication number: 20030220367
    Abstract: This invention relates to compounds which are generally IP receptor antagonists and which are represented.
    Type: Application
    Filed: May 9, 2003
    Publication date: November 27, 2003
    Inventors: Richard Leo Cournoyer, Paul Francis Keitz, Lee Edwin Lowrie, Alexander Victor Muehldorf, Counde O'Yang, Dennis Mitsugu Yasuda
  • 2-(substituted-phenyl)amino-imidazoline derivatives
    Patent number: 6596876
    Abstract: This invention relates to IP receptor antagonists selected from the group of compounds represented by Formula I: where: R1 is a group represented by formula (A), (B) or (C);  and other substituents as defined in the specification, and their pharmaceutically acceptable salts or crystal forms thereof; and pharmaceutical compositions containing them; and methods and their use as therapeutic agents.
    Type: Grant
    Filed: May 31, 2002
    Date of Patent: July 22, 2003
    Assignee: Syntex (U.S.A.) LLC
    Inventors: Keith Roger Bley, Robin Douglas Clark, Alam Jahangir, Bruce Andrew Kowalczyk, Francisco Javier Lopez-Tapia, Alexander Victor Muehldorf, Counde O'Yang, Thomas Weitao Sun
  • 2-(substituted-phenyl)amino-imidazoline derivatives
    Publication number: 20030036655
    Abstract: This invention relates to IP receptor antagonists selected from the group of compounds represented by Formula I: 1
    Type: Application
    Filed: May 31, 2002
    Publication date: February 20, 2003
    Inventors: Keith Roger Bley, Robin Douglas Clark, Alam Jahangir, Bruce Andrew Kowalczyk, Francisco Javier Lopez-Tapia, Alexander Victor Muehldorf, Counde O'Yang, Thomas Weitao Sun
  • 2-(substituted-phenyl)amino-imidazoline derivatives
    Patent number: 6472536
    Abstract: This invention relates to IP receptor antagonists selected from the group of compounds represented by Formula I: where: R1 is a group represented by formula (A), (B) or (C); and other substituents as defined in the specification, and their pharmaceutically acceptable salts or crystal forms thereof; and pharmaceutical compositions containing them; and methods for their use as therapeutic agents.
    Type: Grant
    Filed: September 19, 2000
    Date of Patent: October 29, 2002
    Assignee: Syntex (U.S.A.) LLC
    Inventors: Keith Roger Bley, Robin Douglas Clark, Alam Jahangir, Bruce Andrew Kowalczyk, Francisco Javier Lopez-Tapia, Alexander Victor Muehldorf, Counde O'Yang, Thomas Weitao Sun
  • Aryl carboxylic acid and aryl tetrazole derivatives as IP receptor modulators
    Patent number: 6335459
    Abstract: This invention relates to compounds which are generally IP receptor modulators, particularly IP receptor agonists, and which are represented by Formula I: wherein R1, R2, R3, R4, R5, A, and B are as defined in the specification, and individual isomers, racemic or non-racemic mixtures of isomers, and pharmaceutically acceptable salts or solvates thereof. The invention further relates to pharmaceutical compositions containing such compounds and methods for their use as therapeutic agents.
    Type: Grant
    Filed: December 7, 1999
    Date of Patent: January 1, 2002
    Assignee: Syntex (U.S.A.) LLC
    Inventors: Francisco Javier Lopez-Tapia, Alexander Victor Muehldorf, Counde O'Yang, Daniel Lee Severance
  • Carboxylic acid derivatives as IP antagonists
    Publication number: 20010056100
    Abstract: This invention relates to compounds which are generally IP receptor antagonists and which are represented by Formula I: 1
    Type: Application
    Filed: March 14, 2001
    Publication date: December 27, 2001
    Inventors: Richard Leo Cournoyer, Paul Francis Keitz, Lee Edwin Lowrie Jr., Alexander Victor Muehldorf, Counde O'Yang, Dennis Mitsugu Yasuda
  • 2-(substituted-phenyl)amino-imidazoline derivatives
    Patent number: 6184242
    Abstract: This invention relates to IP receptor antagonists selected from the group of compounds represented by Formula I: where: R1 is a group represented by formula (A), (B) or (C); and other substituents as defined in the specification, and their pharmaceutically acceptable salts or crystal forms thereof; and pharmaceutical compositions containing them; and methods for their use as therapeutic agents.
    Type: Grant
    Filed: August 20, 1998
    Date of Patent: February 6, 2001
    Assignee: Syntex USA (LLC)
    Inventors: Keith Roger Bley, Robin Douglas Clark, Alam Jahangir, Bruce Andrew Kowalczyk, Francisco Javier Lopez-Tapia, Alexander Victor Muehldorf, Counde O'Yang, Thomas Weitao Sun