Abstract: The invention provides a novel polymorphic form I of crystalline bimatoprost, method for preparation thereof and new crystalline intermediates in the preparation. This form I of crystalline bimatoprost is used in purification of crude bimatoprost and in storage of bimatoprost as active pharmaceutical intermediate. Use of the physical form of bimatoprost in the manufacture of a medicament is also disclosed.

Abstract: The invention provides a novel polymorphic form I of crystalline bimatoprost, method for preparation thereof and new crystalline intermediates in the preparation. This form I of crystalline bimatoprost is used in purification of crude bimatoprost and in storage of bimatoprost as active pharmaceutical intermediate. Use of the physical form of bimatoprost in the manufacture of a medicament is also disclosed.

Abstract: The invention provides a novel polymorphic form I of crystalline bimatoprost, method for preparation thereof and new crystalline intermediates in the preparation. This form I of crystalline bimatoprost is used in purification of crude bimatoprost and in storage of bimatoprost as active pharmaceutical intermediate. Use of the physical form of bimatoprost in the manufacture of a medicament is also disclosed.

Abstract: Disclosed is a process for production of highly pure donepezil hydrochloride in the form of polymorph I that does not involve the isolation of donepezil base. The disclosed process involves intramolecular cyclization of N-benzyl-2-(3,4-dimethoxybenzyl)-3-(4-piperidine)propionic acid followed by treatment with HCl.

Abstract: A comminuting apparatus including a filtering screen member for collecting solids carried by an effluent stream. The filtering screen member has an upstream side and a downstream side. The comminutor apparatus further includes a twin shaft grinder for grinding solids contained in the effluent stream and for cleaning the filtering screen member of solids collected thereon. The comminutor apparatus also includes a mounting member in the form of frame-like structure for mounting the twin shaft grinder at a spaced apart distance from the upstream side of the filtering screen member. Additionally, the comminutor apparatus includes a moving device in the form of a drive motor for moving the twin shaft grinder past the upstream side of the filtering screen member such that the twin shaft grinder is continuously spaced from the filtering screen member during the movement of the twin shaft grinder.

Abstract: Disclosed is a process for production of highly pure donepezil hydrochloride that does not involve the isolation of donepezil base. The disclosed process involves intramolecular cyclization of 2-(3,4-dimethoxybenzyl)-3-(N-benzyl-4-piperidine)propionic acid followed by treatment with HCl.

Abstract: A comminuting apparatus including a filtering screen member for collecting solids carried by an effluent stream. The filtering screen member has an upstream side and a downstream side. The comminutor apparatus further includes a twin shaft grinder for grinding solids contained in the effluent stream and for cleaning the filtering screen member of solids collected thereon. The comminutor apparatus also includes a mounting member in the form of frame-like structure for mounting the twin shaft grinder at a spaced apart distance from the upstream side of the filtering screen member. Additionally, the comminutor apparatus includes a moving device in the form of a drive motor for moving the twin shaft grinder past the upstream side of the filtering screen member such that the twin shaft grinder is continuously spaced from the filtering screen member during the movement of the twin shaft grinder.

Abstract: A sewage cleaning and comminuting system is provided with a transverse semi-circular concave filtering screen that extends across an influent channel which intercepts all solids too large to pass therethrough. A combined screen cleaning and comminuting grinder unit is mounted in front of the screen in close relationship, having a concave surface for reciprocating motion therebetween along the full extent of the screen, so as to clean and remove large solids intercepted by the screen surface, and to subsequently comminute such larger solids as they are recirculated back into incoming flow of sewage, wherein the large solids can be ground into smaller solids by the grinder so that they can pass through the screen. A semi-circular screen in combination with a grinder is a preferred embodiment of the system. The system includes a single or multiple drive means whereby the comminuting grinder is actuated and provided with the reciprocating motion along the surface of the screen.

Abstract: A sewage cleaning and comminuting system is provided with a transverse semi-circular concave filtering screen that extends across an influent channel which intercepts all solids too large to pass therethrough. A combined screen cleaning and comminuting grinder unit is mounted in front of the screen in close relationship. It has a concave surface for reciprocating motion therebetween along the full extent of the screen, so as to clean and remove large solids intercepted by the screen surface, and to subsequently comminute such larger solids. As they are recirculated back into incoming flow of sewage, larger solids are ground into smaller solids by the grinder so that they can pass through the screen. A semi-circular screen in combination with a grinder is a preferred embodiment of the system. The system includes a single or multiple drive means whereby the comminuting grinder is actuated and provided with the reciprocating motion along the surface of the screen.