Patents by Inventor Alexander W. Sun

Alexander W. Sun has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • GEM-DISUBSTITUTED PYRROLIDINES, PIPERAZINES, AND DIAZEPANES, AND COMPOSITIONS AND METHODS OF MAKING THE SAME
    Publication number: 20220213081
    Abstract: Described here are transition metal-catalyzed enantioselective arylation and vinylation reactions of ?-substituted lactams, such as ?-lactams. The use of various electrophiles and ligands are described, and result in the construction of ?-quaternary centers in good yields (up to 91% yield) and high enantioselectivities (up to 97% ee).
    Type: Application
    Filed: December 31, 2021
    Publication date: July 7, 2022
    Inventors: Brian M. Stoltz, Alexander W. Sun, Stephan N. Hess, Carina I. Jette, Irina Geibel, Shoshana Bachman, Masaki Hayashi, Hideki Shimizu, Jeremy B. Morgan, Shunya Sakurai, Zachary P. Sercel
  • GEM-DISUBSTITUTED PYRROLIDINES, PIPERAZINES, AND DIAZEPANES, AND COMPOSITIONS AND METHODS OF MAKING THE SAME
    Publication number: 20220119377
    Abstract: Described here are transition metal-catalyzed enantioselective arylation and vinylation reactions of ?-substituted lactams, such as ?-lactams. The use of various electrophiles and ligands are described, and result in the construction of ?-quaternary centers in good yields (up to 91% yield) and high enantioselectivities (up to 97% ee).
    Type: Application
    Filed: December 31, 2021
    Publication date: April 21, 2022
    Inventors: Brian M. Stoltz, Alexander W. Sun, Stephan N. Hess, Carina I. Jette, Irina Geibel, Shoshana Bachman, Masaki Hayashi, Hideki Shimizu, Jeremy B. Morgan, Shunya Sakurai, Zachary P. Sercel
  • CDK INHIBITORS AND USES THEREOF
    Publication number: 20220106325
    Abstract: The present disclosure provides compounds and compositions that are CDK inhibitors selective for CDK4 and/or CDK6, and methods of use thereof.
    Type: Application
    Filed: July 26, 2019
    Publication date: April 7, 2022
    Inventors: Brendan M. O'Boyle, Justin A. Hilf, Scott C. Virgil, Alexander W. Sun, Brian M. Stoltz, Dylan Conklin, Martina S. McDermott, Neil A. O'Brien, Michael J. Palazzolo, Dennis Slamon, Michael D. Bartberger
  • Gem-disubstituted pyrrolidines, piperazines, and diazepanes, and compositions and methods of making the same
    Patent number: 11214568
    Abstract: Described here are transition metal-catalyzed enantioselective arylation and vinylation reactions of ?-substituted lactams, such as ?-lactams. The use of various electrophiles and ligands are described, and result in the construction of ?-quaternary centers in good yields (up to 91% yield) and high enantioselectivities (up to 97% ee).
    Type: Grant
    Filed: October 18, 2019
    Date of Patent: January 4, 2022
    Assignee: California Institute of Technology
    Inventors: Brian M. Stoltz, Alexander W. Sun, Stephan N. Hess, Carina I. Jette, Irina Geibel, Shoshana Bachman, Masaki Hayashi, Hideki Shimizu, Jeremy B. Morgan, Shunya Sakurai, Zachary P. Sercel
  • GEM-DISUBSTITUTED PYRROLIDINES, PIPERAZINES, AND DIAZEPANES, AND COMPOSITIONS AND METHODS OF MAKING THE SAME
    Publication number: 20200199114
    Abstract: Described here are transition metal-catalyzed enantioselective arylation and vinylation reactions of ?-substituted lactams, such as ?-lactams. The use of various electrophiles and ligands are described, and result in the construction of ?-quaternary centers in good yields (up to 91% yield) and high enantioselectivities (up to 97% ee).
    Type: Application
    Filed: October 18, 2019
    Publication date: June 25, 2020
    Inventors: Brian M. Stoltz, Alexander W. Sun, Stephan N. Hess, Carina I. Jette, Irina Geibel, Shoshana Bachman, Masaki Hayashi, Hideki Shimizu, Jeremy B. Morgan, Shunya Sakurai, Zachary P. Sercel
  • CD4-mimetic inhibitors of HIV-1 entry and methods of use thereof
    Patent number: 9403763
    Abstract: Described herein are small-molecule mimics of CD4, which both enter the Phe43 cavity and target Asp368 of gp120, the HIV-1 envelope protein. Also described herein are methods of using these compounds to inhibit the transmission or progression of HIV infection. These compounds exhibit antiviral potency greater than that of a known antiviral, NBD-556, with 100% breadth against clade B and C viruses. Importantly, the compounds do not activate HIV infection of CD4-negative, CCR5-positive cells, in contrast to NBD-556.
    Type: Grant
    Filed: December 14, 2012
    Date of Patent: August 2, 2016
    Inventors: Joseph Sodroski, Judith M. LaLonde, Amos B. Smith, III, Peter D. Kwong, Young Do Kwon, David M. Jones, Alexander W. Sun, Joel R. Courter, Takahiro Soeta, Toyoharu Kobayashi, Amy M. Princiotto, Xueling Wu, John R. Mascola, Arne Schon, Ernesto Freire, Navid Madani, Matthew Le-Khac, Wayne A. Hendrickson, Jongwoo Park
  • CD4-MIMETIC INHIBITORS OF HIV-1 ENTRY AND METHODS OF USE THEREOF
    Publication number: 20140350113
    Abstract: Described herein are small-molecule mimics of CD4, which both enter the Phe43 cavity and target Asp368 of gp120, the HIV-1 envelope protein. Also described herein are methods of using these compounds to inhibit the transmission or progression of HIV infection. These compounds exhibit antiviral potency greater than that of a known antiviral, NBD-556, with 100% breadth against clade B and C viruses. Importantly, the compounds do not activate HIV infection of CD4-negative, CCR5-positive cells, in contrast to NBD-556.
    Type: Application
    Filed: December 14, 2012
    Publication date: November 27, 2014
    Inventors: Joseph Sodroski, Judith M. LaLonde, Amos B. Smith, III, Peter D. Kwong, Young Do Kwon, David M. Jones, Alexander W. Sun, Joel R. Courter, Takahiro Soeta, Toyoharu Kobayashi, Amy M. Princiotto, Xueling Wu, John R. Mascola, Ame Schon, Emesto Freire, Navid Madani, Matthew Le-Khac, Wayne A. Hendrickson