Abstract: A pressure vessel mounting system for mounting a pressure vessel to a vehicle chassis is disclosed. In various embodiments, the system includes a first end frame; a second end frame spaced a distance from the first end frame, the distance being sufficient to receive a pressure vessel between the first end frame and the second end frame; a first side frame extending between the first end frame and the second end frame, the first side frame configured for coupling to a first chassis rail of the vehicle chassis via at least one of the first end frame and the second end frame; and a second side frame extending between the first end frame and the second end frame. Via use of the pressure vessel mounting system, impact damage to pressure vessels may be reduced and/or eliminated.