Patents by Inventor Alexander Waldmann

Alexander Waldmann has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CHIMERIC ANTIGEN RECEPTOR (CAR) THAT TARGETS CHEMOKINE RECEPTOR CCR4 AND ITS USE
    Publication number: 20210315985
    Abstract: A chimeric antigen receptor is disclosed that includes: (a) an scFv comprising a light chain variable domain (VL) and a heavy chain variable domain (VH), wherein the scFv specifically binds to CCR4; (b) a hinge and transmembrane domain from CD8; (c) an intracellular 4-1BB signaling domain; and (d) an intracellular CD3 zeta signaling domain, wherein (a)-(d) are in N to C terminal order. Uses of the chimeric antigen receptor, such as for treating a malignancy, are also disclosed.
    Type: Application
    Filed: June 21, 2021
    Publication date: October 14, 2021
    Applicants: THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Servic, The United States Government as represented by the Department of Veterans Affairs
    Inventors: Liyanage Parakrama Perera, Thomas Alexander Waldmann, Kevin Charles Conlon, Pin-Yu Perera
  • Chimeric antigen receptor (CAR) that targets chemokine receptor CCR4 and its use
    Patent number: 11077178
    Abstract: A chimeric antigen receptor is disclosed that includes: (a) an scFv comprising a light chain variable domain (VL) and a heavy chain variable domain (VH), wherein the scFv specifically binds to CCR4; (b) a hinge and transmembrane domain from CD8; (c) an intracellular 4-1BB signaling domain; and (d) an intracellular CD3 zeta signaling domain, wherein (a)-(d) are in N to C terminal order. Uses of the chimeric antigen receptor, such as for treating a malignancy, are also disclosed.
    Type: Grant
    Filed: September 20, 2017
    Date of Patent: August 3, 2021
    Assignees: The United States of America, as represented by the Secretary, Department of Health and Human Services, The United States Government as represented by the Department of Veterans Affairs
    Inventors: Liyanage Parakrama Perera, Thomas Alexander Waldmann, Kevin Charles Conlon, Pin-Yu Perera
  • CHIMERIC ANTIGEN RECEPTOR (CAR) THAT TARGETS CHEMOKINE RECEPTOR CCR4 AND ITS USE
    Publication number: 20190233526
    Abstract: A chimeric antigen receptor is disclosed that includes: (a) an scFv comprising a light chain variable domain (VL) and a heavy chain variable domain (VH), wherein the scFv specifically binds to CCR4; (b) a hinge and transmembrane domain from CD8; (c) an intracellular 4-1BB signaling domain; and (d) an intracellular CD3 zeta signaling domain, wherein (a)-(d) are in N to C terminal order. Uses of the chimeric antigen receptor, such as for treating a malignancy, are also disclosed.
    Type: Application
    Filed: September 20, 2017
    Publication date: August 1, 2019
    Applicants: THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human, The United States Government as represented by the Department of Veterans Affairs
    Inventors: Liyanage Parakrama Perera, Thomas Alexander Waldmann, Kevin Charles Conlon, Pin-Yu Perera
  • Device and method for sensing an object or a person in the interior of a vehicle and vehicle occupant protection apparatus in a vehicle with such a device
    Patent number: 6773029
    Abstract: Objects of persons in a vehicle are detected with a sensor. The data of the sensor signal or evaluated sensor data are transmitted to a remote control unit for an occupant protection system. The sensor data are in addition stored in a device comprising the sensor if the control unit indicates that an impact has been recognized.
    Type: Grant
    Filed: August 27, 2001
    Date of Patent: August 10, 2004
    Assignee: Siemens Aktiengesellschaft
    Inventors: Reinhard Hamperl, Gerhard Mader, Reinhard Rösl, Christoph Roth, Thomas Stierle, Alexander Waldmann
  • Method and device for sensing and object or a person in the interior of a vehicle
    Patent number: 6452288
    Abstract: In order to sense an object or a person in the interior of a vehicle, a laser emits a laser pulse. The laser pulse which is reflected at an object or a person is registered and evaluated. The energy content of a following laser pulse is determined based on a characteristic variable of the reflected laser pulse such as its power or its energy content.
    Type: Grant
    Filed: February 25, 2000
    Date of Patent: September 17, 2002
    Assignee: Siemens Aktiengesellschaft
    Inventors: Christoph Roth, Alexander Waldmann, Reinhard Hamperl, Thomas Stierle, Reinhard Roesl, Gerhard Mader
  • Device and method for sensing an object or a person in the interior of a vehicle
    Patent number: 6437461
    Abstract: In order to sense an object or a person in the interior of a vehicle, laser pulses are output by a laser. Sensing devices are provided for sensing a characteristic variable that is decisive for the transmission energy of the laser. The transmission energy is reduced or the emission of a laser pulse is prevented as a function of the sensed characteristic variable.
    Type: Grant
    Filed: February 25, 2000
    Date of Patent: August 20, 2002
    Assignee: Siemens Aktiengesellschaft
    Inventors: Christoph Roth, Alexander Waldmann, Reinhard Hamperl, Thomas Stierle, Reinhard Roesl, Gerhard Mader
  • Device and method for sensing an objects or a person in the interior of a vehicle and vehicle occupant protection apparatus in a vehicle with such a device
    Publication number: 20020074786
    Abstract: Objects of persons in a vehicle are detected with a sensor. The data of the sensor signal or evaluated sensor data are transmitted to a remote control unit for an occupant protection system. The sensor data are in addition stored in a device comprising the sensor if the control unit indicates that an impact has been recognized.
    Type: Application
    Filed: August 27, 2001
    Publication date: June 20, 2002
    Inventors: Reinhard Hamperl, Gerhard Mader, Reinhard Rosl, Christoph Roth, Thomas Stierle, Alexander Waldmann
  • Device for sensing an object or a person in the interior of a vehicle and method for operating such a device
    Patent number: 6313739
    Abstract: A sensor which is installed in a vehicle, for sensing an object or a person, is operated for adjustment purposes in a test mode. The installation position of the sensor or of the device in the vehicle is changed with an adjustment device as a function of the evaluation of the test data which are determined. Alternatively, or in addition, a message can be issued as a function of the result of the evaluation. The invention ensures that the device is installed at a precise location in the vehicle and the position of vehicle occupants is thus determined precisely.
    Type: Grant
    Filed: February 25, 2000
    Date of Patent: November 6, 2001
    Assignee: Siemens Aktiengesellschaft
    Inventors: Christoph Roth, Alexander Waldmann, Reinhard Hamperl, Thomas Stierle, Reinhard Roesl, Gerhard Mader
  • Method and device for sensing an object or a person in the interior of a vehicle
    Patent number: 6255939
    Abstract: A sensor for detecting an object or a person in the interior of a vehicle consumes a first average power in a normal operating mode. The power supply for supplying the sensor is monitored. The sensor is operated with a second average power which is reduced in comparison with the first average power if the power supply is considered as no longer being sufficient for the normal operating mode.
    Type: Grant
    Filed: February 25, 2000
    Date of Patent: July 3, 2001
    Assignee: Siemens Aktiengesellschaft
    Inventors: Christoph Roth, Alexander Waldmann, Reinhard Hamperl, Thomas Stierle, Reinhard Roesl, Gerhard Mader
  • Constructs encoding recombinant antibody-toxin fusion proteins
    Patent number: 6051405
    Abstract: The present invention describes constructs encoding recombinant scFv-toxin fusion proteins which selectively kill cells bearing appropriate antigens or receptors.
    Type: Grant
    Filed: April 8, 1992
    Date of Patent: April 18, 2000
    Assignees: The United States of America as represented by the Secretary of the Department of Health and Human Services, Protein Design Labs, Inc.
    Inventors: David FitzGerald, Vijay Kumar Chaudhary, Ira Harry Pastan, Thomas Alexander Waldmann, Cary L Queen
  • Recombinant antibody-toxin fusion protein
    Patent number: 5863745
    Abstract: The present invention describes recombinant antibody toxin fusion proteins which selectively kill cells bearing appropriate antigens or receptors.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: January 26, 1999
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: David J. Fitzgerald, Vijay Kumar Chaudhary, Ira H. Pastan, Thomas Alexander Waldmann, Cary L. Queen
  • Recombinant antibody-toxin fusion protein
    Patent number: 5696237
    Abstract: The present invention describes recombinant antibody toxin fusion proteins which selectively kill cells bearing appropriate antigens or receptors.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: December 9, 1997
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: David FitzGerald, Vijay Kumar Chaudhary, Ira Harry Pastan, Thomas Alexander Waldmann, Cary L. Queen