Patents by Inventor Alexander Watters
Alexander Watters has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11807677Abstract: Described herein are engineered microbe-targeting molecules, microbe-targeting articles, kits comprising the same, and uses thereof. Such microbe-targeting molecules, microbe-targeting articles, or the kits comprising the same can not only bind or capture of a microbe or microbial matter thereof, but they also have improved capability (e g, enhanced sensitivity or signal intensity) of detecting a microbe or microbial matter. Thus, the microbe-targeting molecules, microbe-targeting articles, and/or the kit described herein can be used in various applications, e.g., but not limited to assays for detection of a microbe or microbial matter, diagnostic and/or therapeutic agents for diagnosis and/or treatment of an infection caused by microbes in a subject or any environmental surface, and/or devices for removal of a microbe or microbial matter from a fluid.Type: GrantFiled: December 16, 2021Date of Patent: November 7, 2023Assignee: PRESIDENT AND FELLOWS OF HARVARD COLLEGEInventors: Alexander Watters, Brendon Dusel, Michael Super, Mark Cartwright, Donald E. Ingber
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Publication number: 20230287142Abstract: Described herein are polypeptides, compositions, kits, and analyte detection systems for the detection of the presence or absence of small molecules (e.g. histamine and/or histidine) in a test sample.Type: ApplicationFiled: July 6, 2021Publication date: September 14, 2023Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGEInventors: Alexander WATTERS, Pawan JOLLY, Donald E. INGBER, Thomas CUNNINGHAM
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Publication number: 20220281955Abstract: Described herein are engineered microbe-targeting molecules, microbe-targeting articles, kits comprising the same, and uses thereof. Such microbe-targeting molecules, microbe-targeting articles, or the kits comprising the same can not only bind or capture of a microbe or microbial matter thereof, but they also have improved capability (e g, enhanced sensitivity or signal intensity) of detecting a microbe or microbial matter. Thus, the microbe-targeting molecules, microbe-targeting articles, and/or the kit described herein can be used in various applications, e.g., but not limited to assays for detection of a microbe or microbial matter, diagnostic and/or therapeutic agents for diagnosis and/or treatment of an infection caused by microbes in a subject or any environmental surface, and/or devices for removal of a microbe or microbial matter from a fluid.Type: ApplicationFiled: December 16, 2021Publication date: September 8, 2022Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGEInventors: Alexander WATTERS, Brendon Dusel, Michael SUPER, Mark CARTWRIGHT, Donald E. INGBER
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Patent number: 11236149Abstract: Described herein are engineered microbe-targeting molecules, microbe-targeting articles, kits comprising the same, and uses thereof. Such microbe-targeting molecules, microbe-targeting articles, or the kits comprising the same can not only bind or capture of a microbe or microbial matter thereof, but they also have improved capability (e.g., enhanced sensitivity or signal intensity) of detecting a microbe or microbial matter. Thus, the microbe-targeting molecules, microbe-targeting articles, and/or the kit described herein can be used in various applications, e.g., but not limited to assays for detection of a microbe or microbial matter, diagnostic and/or therapeutic agents for diagnosis and/or treatment of an infection caused by microbes in a subject or any environmental surface, and/or devices for removal of a microbe or microbial matter from a fluid.Type: GrantFiled: May 20, 2020Date of Patent: February 1, 2022Assignee: PRESIDENT AND FALLOWS OF HARVARD COLLEGEInventors: Alexander Watters, Brendon Dusel, Michael Super, Mark Cartwright, Donald E. Ingber
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Publication number: 20200283506Abstract: Described herein are engineered microbe-targeting molecules, microbe-targeting articles, kits comprising the same, and uses thereof. Such microbe-targeting molecules, microbe-targeting articles, or the kits comprising the same can not only bind or capture of a microbe or microbial matter thereof, but they also have improved capability (e.g., enhanced sensitivity or signal intensity) of detecting a microbe or microbial matter. Thus, the microbe-targeting molecules, microbe-targeting articles, and/or the kit described herein can be used in various applications, e.g., but not limited to assays for detection of a microbe or microbial matter, diagnostic and/or therapeutic agents for diagnosis and/or treatment of an infection caused by microbes in a subject or any environmental surface, and/or devices for removal of a microbe or microbial matter from a fluid.Type: ApplicationFiled: May 20, 2020Publication date: September 10, 2020Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGEInventors: Alexander WATTERS, Brendon Dusel, Michael SUPER, Mark CARTWRIGHT, Donald E. INGBER
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Patent number: 10696733Abstract: Described herein are engineered microbe-targeting molecules, microbe-targeting articles, kits comprising the same, and uses thereof. Such microbe-targeting molecules, microbe-targeting articles, or the kits comprising the same can not only bind or capture of a microbe or microbial matter thereof, but they also have improved capability (e.g., enhanced sensitivity or signal intensity) of detecting a microbe or microbial matter. Thus, the microbe-targeting molecules, microbe-targeting articles, and/or the kit described herein can be used in various applications, e.g., but not limited to assays for detection of a microbe or microbial matter, diagnostic and/or therapeutic agents for diagnosis and/or treatment of an infection caused by microbes in a subject or any environmental surface, and/or devices for removal of a microbe or microbial matter from a fluid.Type: GrantFiled: August 28, 2019Date of Patent: June 30, 2020Assignee: PRESIDENT AND FELLOWS OF HARVARD COLLEGEInventors: Alexander Watters, Brendon Dusel, Michael Super, Mark Cartwright, Donald E. Ingber
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Publication number: 20190389935Abstract: Described herein are engineered microbe-targeting molecules, microbe-targeting articles, kits comprising the same, and uses thereof. Such microbe-targeting molecules, microbe-targeting articles, or the kits comprising the same can not only bind or capture of a microbe or microbial matter thereof, but they also have improved capability (e.g., enhanced sensitivity or signal intensity) of detecting a microbe or microbial matter. Thus, the microbe-targeting molecules, microbe-targeting articles, and/or the kit described herein can be used in various applications, e.g., but not limited to assays for detection of a microbe or microbial matter, diagnostic and/or therapeutic agents for diagnosis and/or treatment of an infection caused by microbes in a subject or any environmental surface, and/or devices for removal of a microbe or microbial matter from a fluid.Type: ApplicationFiled: August 28, 2019Publication date: December 26, 2019Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGEInventors: Alexander WATTERS, Brendon DUSEL, Michael SUPER, Mark CARTWRIGHT, Donald E. INGBER
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Patent number: 10435457Abstract: Described herein are engineered microbe-targeting molecules, microbe-targeting articles, kits comprising the same, and uses thereof. Such microbe-targeting molecules, microbe-targeting articles, or the kits comprising the same can not only bind or capture of a microbe or microbial matter thereof, but they also have improved capability (e.g., enhanced sensitivity or signal intensity) of detecting a microbe or microbial matter. Thus, the microbe-targeting molecules, microbe-targeting articles, and/or the kit described herein can be used in various applications, e.g., but not limited to assays for detection of a microbe or microbial matter, diagnostic and/or therapeutic agents for diagnosis and/or treatment of an infection caused by microbes in a subject or any environmental surface, and/or devices for removal of a microbe or microbial matter from a fluid.Type: GrantFiled: August 4, 2016Date of Patent: October 8, 2019Assignee: PRESIDENT AND FELLOWS OF HARVARD COLLEGEInventors: Alexander Watters, Brendon Dusel, Michael Super, Mark Cartwright, Donald E. Ingber
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Publication number: 20190145980Abstract: The invention relates to methods of detection, capture, isolation and targeting of cancer cells for example circulating tumor cells (CTCs) using carbohydrate recognition domain of a lectin. The invention relates to methods of diagnosis, prognosis and treatment of cancer.Type: ApplicationFiled: April 10, 2017Publication date: May 16, 2019Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGEInventors: Joo Hun KANG, Donald INGBER, Michael SUPER, Alexander WATTERS, Harry DRISCOLL
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Publication number: 20190077850Abstract: Described herein are engineered microbe-targeting or microbe-binding molecules, kits comprising the same and uses thereof. The microbe-targeting or microbe-binding molecules can comprise a microbe surface-binding domain linked to a portion of an Fc region. Further, the microbe-targeting molecules can be conjugated to substrate (e.g., a magnetic particle) to form a microbe-targeting substrate. Such microbe-targeting molecules and/or substrates and the kits comprising the same can be used in various applications, such as diagnosis and/or treatment of an infection caused by microbes. Moreover, the microbe-targeting molecules and/or substrates can be easily regenerated after use.Type: ApplicationFiled: August 9, 2018Publication date: March 14, 2019Inventors: Donald E. Ingber, Michael Super, Alexander Watters
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Publication number: 20180371058Abstract: Described herein are engineered microbe-targeting molecules, microbe-targeting articles, kits comprising the same, and uses thereof. Such microbe-targeting molecules, microbe-targeting articles, or the kits comprising the same can not only bind or capture of a microbe or microbial matter thereof, but they also have improved capability (e.g., enhanced sensitivity or signal intensity) of detecting a microbe or microbial matter. Thus, the microbe-targeting molecules, microbe-targeting articles, and/or the kit described herein can be used in various applications, e.g., but not limited to assays for detection of a microbe or microbial matter, diagnostic and/or therapeutic agents for diagnosis and/or treatment of an infection caused by microbes in a subject or any environmental surface, and/or devices for removal of a microbe or microbial matter from a fluid.Type: ApplicationFiled: August 4, 2016Publication date: December 27, 2018Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGEInventors: Alexander WATTERS, Brendon Dusel, Michael SUPER, Mark CARTWRIGHT, Donald E. INGBER
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Publication number: 20170362307Abstract: Described herein are engineered microbe-targeting or microbe-binding molecules, kits comprising the same and uses thereof. Some particular embodiments of the microbe-targeting or microbe-binding molecules comprise a carbohydrate recognition domain of mannose-binding lectin, or a fragment thereof, linked to a portion of a Fc region. In some embodiments, the microbe-targeting molecules or microbe-binding molecules can be conjugated to a substrate, e.g., a magnetic microbead, forming a microbe-targeting substrate (e.g., a microbe-targeting magnetic microbead). Such microbe-targeting molecules and/or substrates and the kits comprising the same can bind and/or capture of a microbe and/or microbial matter thereof, and can thus be used in various applications, e.g., diagnosis and/or treatment of an infection caused by microbes such as sepsis in a subject or any environmental surface.Type: ApplicationFiled: January 25, 2017Publication date: December 21, 2017Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGEInventors: Donald E. INGBER, Michael SUPER, Jeffrey Charles WAY, Mark J. CARTWRIGHT, Julia B. BERTHET, Dinah R. SUPER, Martin M. ROTTMAN, Alexander WATTERS
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Patent number: 9632085Abstract: Embodiments of various aspects described herein are directed to methods, compositions, kits and systems for rapid determination of antibiotic susceptibility of a microbe within hours after a sample is collected. In some embodiments, the methods, compositions, kits and systems described herein can allow determination of antibiotic susceptibility of a microbe based on a small number of microbes, e.g., as few as 5-10 microbes bound to a microbe-targeting substrate described herein.Type: GrantFiled: February 28, 2013Date of Patent: April 25, 2017Assignee: President and Fellows of Harvard CollegeInventors: Michael Super, Donald E. Ingber, Mark J. Cartwright, Alexander Watters, John Samuel Workman, Daniel Levner, Martin Marcus Rottman
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Patent number: 9593160Abstract: Described herein are engineered microbe-targeting or microbe-binding molecules, kits comprising the same and uses thereof. Some particular embodiments of the microbe-targeting or microbe-binding molecules comprise a carbohydrate recognition domain of mannose-binding lectin, or a fragment thereof, linked to a portion of a Fc region. In some embodiments, the microbe-targeting molecules or microbe-binding molecules can be conjugated to a substrate, e.g., a magnetic microbead, forming a microbe-targeting substrate (e.g., a microbe-targeting magnetic microbead). Such microbe-targeting molecules and/or substrates and the kits comprising the same can bind and/or capture of a microbe and/or microbial matter thereof, and can thus be used in various applications, e.g., diagnosis and/or treatment of an infection caused by microbes such as sepsis in a subject or any environmental surface.Type: GrantFiled: July 18, 2012Date of Patent: March 14, 2017Assignee: PRESIDENT AND FELLOWS OF HARVARD COLLEGEInventors: Donald E. Ingber, Michael Super, Jeffrey Charles Way, Mark J. Cartwright, Julia B. Berthet, Dinah R. Super, Martin M. Rottman, Alexander Watters
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Publication number: 20160311877Abstract: Described herein are engineered microbe-targeting molecules, microbe-targeting articles, kits comprising the same, and uses thereof. Such microbe-targeting molecules, microbe-targeting articles, or the kits comprising the same can bind or capture of a microbe or microbial matter thereof, and can thus be used in various applications, such as diagnosis or treatment of an infection caused by microbes in a subject or any environmental surface.Type: ApplicationFiled: December 18, 2014Publication date: October 27, 2016Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGEInventors: Alexander WATTERS, Donald INGBER, Mark CARTWRIGHT, Michael SUPER, Martin ROTTMAN, Evangelina MURRAY, Brendon DUSEL
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Publication number: 20150064703Abstract: Embodiments of various aspects described herein are directed to methods, compositions, kits and systems for rapid determination of antibiotic susceptibility of a microbe within hours after a sample is collected. In some embodiments, the methods, compositions, kits and systems described herein can allow determination of antibiotic susceptibility of a microbe based on a small number of microbes, e.g., as few as 5-10 microbes bound to a microbe-targeting substrate described herein.Type: ApplicationFiled: February 28, 2013Publication date: March 5, 2015Inventors: Michael Super, Donald E. Ingber, Mark J. Cartwright, Alexander Watters, John Samuel Workman, Daniel Levner, Martin Rottman
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Publication number: 20140227723Abstract: Described herein are engineered microbe-targeting or microbe-binding molecules, kits comprising the same and uses thereof. Some particular embodiments of the microbe-targeting or microbe-binding molecules comprise a carbohydrate recognition domain of mannose-binding lectin, or a fragment thereof, linked to a portion of a Fc region. In some embodiments, the microbe-targeting molecules or microbe-binding molecules can be conjugated to a substrate, e.g., a magnetic microbead, forming a microbe-targeting substrate (e.g., a microbe-targeting magnetic microbead). Such microbe-targeting molecules and/or substrates and the kits comprising the same can bind and/or capture of a microbe and/or microbial matter thereof, and can thus be used in various applications, e.g., diagnosis and/or treatment of an infection caused by microbes such as sepsis in a subject or any environmental surface.Type: ApplicationFiled: July 18, 2012Publication date: August 14, 2014Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGEInventors: Donald E. Ingber, Michael Super, Jeffrey Charles Way, Mark J. Cartwright, Julia B. Berthet, Dinah R. Super, Martin M. Rottman, Alexander Watters