Patents by Inventor Alexander Wayne SCHAMMEL

Alexander Wayne SCHAMMEL has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • APOL1 inhibitors and methods of use
    Patent number: 11976067
    Abstract: Provided herein are compounds of formula (II): or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, wherein m, n, p, R1, R2, R3, L1, L2, L3, R4, X1, X2, X3, and X4 are as defined herein. Also provided are methods of preparing compounds of formula (II), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing. Also provided are methods of inhibiting APOL1 and methods of treating an APOL1-mediated disease, disorder, or condition in an individual.
    Type: Grant
    Filed: January 17, 2023
    Date of Patent: May 7, 2024
    Assignee: Maze Therapeutics, Inc.
    Inventors: Patrick Sang Tae Lee, Todd Jonathan August Ewing, Adam Neil Reid, Christopher Joseph Sinz, Birong Zhang, Sarah M. Bronner, David John Morgans, Jr., Maarten Hoek, Victoria Anne Assimon, Chris Ziebenhaus, Alexander Wayne Schammel
  • Substituted pyridine derivatives as SARM1 inhibitors
    Patent number: 11970481
    Abstract: This disclosure is drawn to substituted pyridine compounds and compositions, and associated methods, useful for inhibition of SARM1 activity and/or for treating or preventing a neurological diseases.
    Type: Grant
    Filed: October 4, 2023
    Date of Patent: April 30, 2024
    Assignee: NURA BIO, INC.
    Inventors: Jennifer Aiden Kozak, Sean Pomeroy Brown, Christopher Michael Tegley, Alexander Wayne Schammel, Liusheng Zhu, Maximiliano De La Higuera Macias, Shilpa Sambashivan
  • SUBSTITUTED PYRIDINE DERIVATIVES AS SARM1 INHIBITORS
    Publication number: 20240116901
    Abstract: This disclosure is drawn to substituted pyridine compounds and compositions, and associated methods, useful for inhibition of SARM1 activity and/or for treating or preventing a neurological diseases.
    Type: Application
    Filed: October 4, 2023
    Publication date: April 11, 2024
    Inventors: Jennifer Aiden KOZAK, Sean Pomeroy BROWN, Christopher Michael TEGLEY, Alexander Wayne SCHAMMEL, Liusheng ZHU, Maximiliano DE LA HIGUERA MACIAS, Shilpa SAMBASHIVAN
  • SUBSTITUTED PYRIDINE DERIVATIVES AS SARM1 INHIBITORS
    Publication number: 20230339913
    Abstract: This disclosure is drawn to substituted pyridine compounds and compositions, and associated methods, useful for inhibition of SARM1 activity and/or for treating or preventing a neurological diseases.
    Type: Application
    Filed: August 3, 2021
    Publication date: October 26, 2023
    Inventors: Jennifer Aiden KOZAK, Sean Pomeroy BROWN, Michael Christopher TEGLEY, Alexander Wayne SCHAMMEL, Liusheng ZHU, Maximiliano DE LA HIGUERA MACIAS, Shilpa SAMBASHIVAN
  • APOL1 INHIBITORS AND METHODS OF USE
    Publication number: 20230265096
    Abstract: Provided herein are compounds of formula (II): or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, wherein m, n, p, R1, R2, R3, L1, L2, L3, R4, X1, X2, X3, and X4 are as defined herein. Also provided are methods of preparing compounds of formula (II), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing. Also provided are methods of inhibiting APOL1 and methods of treating an APOL1-mediated disease, disorder, or condition in an individual.
    Type: Application
    Filed: January 17, 2023
    Publication date: August 24, 2023
    Inventors: Patrick Sang Tae LEE, Todd Jonathan August EWING, Adam Neil REID, Christopher Joseph SINZ, Birong ZHANG, Sarah M. BRONNER, David John MORGANS, Jr., Maarten HOEK, Victoria Anne ASSIMON, Chris ZIEBENHAUS, Alexander Wayne SCHAMMEL
  • ANTI-CANCER COMPOUNDS AND CONJUGATES THEREOF
    Publication number: 20200316214
    Abstract: Disclosed herein are compounds, drug-conjugates thereof, methods of preparing drug-conjugates, and uses thereof. Also disclosed are pharmaceutical compositions and methods of treatment. The compounds and drug-conjugates disclosed herein can be used to treat a variety of conditions, diseases and ailments such as bladder cancer, breast cancer, colon cancer, rectal cancer, endometrial cancer, kidney cancer, lung cancer, melanoma, non-Hodgkin lymphoma, glioblastoma, pancreatic cancer, prostate cancer, and thyroid cancer.
    Type: Application
    Filed: June 18, 2020
    Publication date: October 8, 2020
    Inventors: Oliver Booth Vining, Venkata Rami Reddy Macherla, Alexander Wayne Schammel, Ippei Usui, Jacob Neal Beverage, Elizabeth Paige Stout, Bryan Junn Lee, Steven Bruce Cohen, Eduardo Esquenazi
  • Anti-cancer compounds and conjugates thereof
    Patent number: 10722593
    Abstract: Disclosed are compounds based on dolastatins, drug-conjugates, methods of preparing drug-conjugates, and uses thereof. Also disclosed are pharmaceutical compositions and methods of treatment. The compounds and drug-conjugates disclosed herein can be used to treat diseases such as bladder cancer, breast cancer, colon cancer, rectal cancer, endometrial cancer, kidney cancer, lung cancer, melanoma, non-Hodgkin lymphoma, glioblastoma, pancreatic cancer, prostate cancer, and thyroid cancer.
    Type: Grant
    Filed: September 27, 2016
    Date of Patent: July 28, 2020
    Assignee: SIRENAS LLC
    Inventors: Oliver Booth Vining, Venkata Rami Reddy Macherla, Alexander Wayne Schammel, Ippei Usui, Jacob Neal Beverage, Elizabeth Paige Stout, Bryan Junn Lee, Steven Bruce Cohen, Eduardo Esquenazi
  • Cyclic peptide analogs and conjugates thereof
    Patent number: 10472395
    Abstract: Provided are cyclic peptide analogs, conjugates comprising such compounds, and pharmaceutical compositions comprising such compounds and conjugates, and methods of treating cancer with such compounds and conjugates.
    Type: Grant
    Filed: March 3, 2016
    Date of Patent: November 12, 2019
    Assignee: Sirenas LLC
    Inventors: Venkat Rami Reddy Macherla, Alexander Wayne Schammel, Ippei Usui, Elizabeth Paige Stout, Jacob Neal Beverage, Bryan Junn Lee, Steven Bruce Cohen
  • ANTI-CANCER COMPOUNDS AND CONJUGATES THEREOF
    Publication number: 20180296688
    Abstract: Disclosed are compounds based on dolastatins, drug-conjugates, methods of preparing drug-conjugates, and uses thereof. Also disclosed are pharmaceutical compositions and methods of treatment. The compounds and drug-conjugates disclosed herein can be used to treat diseases such as bladder cancer, breast cancer, colon cancer, rectal cancer, endometrial cancer, kidney cancer, lung cancer, melanoma, non-Hodgkin lymphoma, glioblastoma, pancreatic cancer, prostate cancer, and thyroid cancer.
    Type: Application
    Filed: September 27, 2016
    Publication date: October 18, 2018
    Inventors: Oliver Booth Vining, Venkata Rami Reddy Macherla, Alexander Wayne Schammel, Ippei Usui, Jacob Neal Beverage, Elizabeth Paige Stout, Bryan Junn Lee, Steven Bruce Cohen, Eduardo Esquenazi
  • CYCLIC PEPTIDE ANALOGS AND CONJUGATES THEREOF
    Publication number: 20170015710
    Abstract: Provided are cyclic peptide analogs, conjugates comprising such compounds, and pharmaceutical compositions comprising such compounds and conjugates, and methods of treating cancer with such compounds and conjugates.
    Type: Application
    Filed: March 3, 2016
    Publication date: January 19, 2017
    Applicant: Sirenas LLC
    Inventors: Venkat Rami Reddy MACHERLA, Alexander Wayne SCHAMMEL, Ippei USUI, Elizabeth Paige STOUT, Jacob Neal BEVERAGE, Bryan Junn LEE, Steven Bruce COHEN