Patents by Inventor Alexander Weymouth-Wilson

Alexander Weymouth-Wilson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • LARGE SCALE PROCESS
    Publication number: 20230063538
    Abstract: A process for preparing a compound of formula (I) wherein the process is suitable for large scale synthesis. The process includes the consecutive steps of a) reacting a compound of formula IX and a catalyst and optionally adding a base in an organic solvent and optional adding a basic fluoride source agent under suitable conditions to obtain a compound of formula X and b) removing the protective groups of the compound X to obtain the compound formula (I).
    Type: Application
    Filed: December 16, 2020
    Publication date: March 2, 2023
    Applicant: GALECTO BIOTECH AB
    Inventors: Lise GRAVELLE, Fredrik ZETTERBERG, Andrew TYRRELL, Christine KINNAERT, Alexander WEYMOUTH-WILSON, Robert CLARKSON
  • Intermediates for the synthesis of bile acid derivatives, in particular of obeticholic acid
    Patent number: 11479577
    Abstract: The present invention relates to compounds which are intermediates in the synthesis of bile acid derivatives with pharmacological activity. The invention relates to compounds of general formula (I): wherein: , R1, R2, R3, R4, R5, R6 and Y are as defined herein. The compounds are intermediates in the synthesis of synthetic bile acids which are useful in the treatment of conditions such as liver disease. In addition, the invention relates to a method of synthesizing these intermediates and a method of preparing obeticholic acid and obeticholic acid analogues from the compounds of the invention.
    Type: Grant
    Filed: February 26, 2021
    Date of Patent: October 25, 2022
    Assignee: NZP UK Limited
    Inventors: Alexander Weymouth-Wilson, Zofia Komsta, Laura Wallis, Timothy Evans, Ieuan Davies, Carl Otter, Rhys Batchelor
  • LARGE SCALE PROCESS OF 3,3'-DIDEOXY-3,3'-BIS-[4-(3-FLUOROPHENYL)-1H-1,2,3-TRIAZOL-1-YL]-1,1'-SULFANEDIYL-DI-BETA-D-GALACTOPYRANOSIDE
    Publication number: 20220251132
    Abstract: The present invention relates to a process for preparing a compound of formula (I) wherein said process is suitable for large scale synthesis.
    Type: Application
    Filed: June 24, 2020
    Publication date: August 11, 2022
    Applicant: GALECTO BIOTECH AB
    Inventors: Fredrik ZETTERBERG, Andrew TYRELL, Ulf NILSSON, Anders BERGH, Jonathan CUMMINS, Alexander WEYMOUTH-WILSON, Robert CLARKSON
  • Intermediates for the Synthesis of Bile Acid Derivatives, in Particular of Obeticholic Acid
    Publication number: 20210179661
    Abstract: The present invention relates to compounds which are intermediates in the synthesis of bile acid derivatives with pharmacological activity. The invention relates to compounds of general formula (I): wherein: , R1, R2, R3, R4, R5, R6 and Y are as defined herein. The compounds are intermediates in the synthesis of synthetic bile acids which are useful in the treatment of conditions such as liver disease. In addition, the invention relates to a method of synthesizing these intermediates and a method of preparing obeticholic acid and obeticholic acid analogues from the compounds of the invention.
    Type: Application
    Filed: February 26, 2021
    Publication date: June 17, 2021
    Applicant: NZP UK Limited
    Inventors: Alexander Weymouth-Wilson, Zofia Komsta, Laura Wallis, Timothy Evans, Ieuan Davies, Carl Otter, Rhys Batchelor
  • Intermediates for the synthesis of bile acid derivatives, in particular of obeticholic acid
    Patent number: 10968250
    Abstract: The present invention relates to compounds which are intermediates in the synthesis of bile acid derivatives with pharmacological activity. The invention relates to compounds of general formula (I): wherein: , R1, R2, R3, R4, R5, R6 and Y are as defined herein. The compounds are intermediates in the synthesis of synthetic bile acids which are useful in the treatment of conditions such as liver disease. In addition, the invention relates to a method of synthesizing these intermediates and a method of preparing obeticholic acid and obeticholic acid analogues from the compounds of the invention.
    Type: Grant
    Filed: May 18, 2017
    Date of Patent: April 6, 2021
    Assignee: NZP UK Limited
    Inventors: Alexander Weymouth-Wilson, Zofia Komsta, Laura Wallis, Timothy Evans, Ieuan Davies, Carl Otter, Rhys Batchelor
  • Process and intermediates for the 6,7-alpha-epoxidation of steroid 4,6-dienes
    Patent number: 10766921
    Abstract: The invention relates to a process for preparing a compound of general formula (Ia): wherein R2, Y, R4 and R5 are as defined herein, wherein the epoxidation is conducted using an oxidant and methyltrioxorhenium as a catalyst (MeReO3). The invention also relates to certain compounds per se. The compounds are intermediates in the synthesis of synthetic bile acids.
    Type: Grant
    Filed: May 18, 2017
    Date of Patent: September 8, 2020
    Assignee: NZP UK Limited
    Inventors: Alexander Weymouth-Wilson, Zofia Komsta, Laura Wallis, Timothy Evans
  • 6.alpha.-alkyl-6,7-dione steroids as intermediates for the production of steroidal FXR modulators
    Patent number: 10597423
    Abstract: Disclosed herein is a process for the preparation of a compound of formula (I) and related methods. The compounds of formula (I) are intermediates in the synthesis of synthetic bile acids and its analogues, and the compounds of formula (I) have pharmacological activity. Methods include the synthesizing of these intermediates, and methods of preparing obeticholic acid and obeticholic acid analogues from the prepared compounds.
    Type: Grant
    Filed: October 17, 2018
    Date of Patent: March 24, 2020
    Assignee: NZP UK Limited
    Inventors: Alexander Weymouth-Wilson, Zofia Komsta, James Boydell, Laura Wallis, Carl Otter, Ieuan Davies, Rob Clarkson
  • 6.alpha.-alkyl-3,7-dione steroids as intermediates for the production of steroidal FXR modulators
    Patent number: 10538550
    Abstract: The invention relates to compounds of formula (I) wherein R1, R2, Y1, R4 and R5 are as defined herein. The compounds are intermediates in the synthesis of synthetic bile acid derivatives with pharmacological activity. The invention further provides methods related to the synthesizing of these intermediates, and methods of preparing obeticholic acid and obeticholic acid analogues from the compounds of the invention.
    Type: Grant
    Filed: November 19, 2015
    Date of Patent: January 21, 2020
    Assignee: NZP UK Limited
    Inventors: Alexander Weymouth-Wilson, Zofia Komsta, James Boydell, Laura Wallis, Rhys Batchelor, Carl Otter, Ieuan Davies
  • Process and Intermediates for the 6,7-Alpha-Epoxidation of Steroid 4,6-Dienes
    Publication number: 20190309012
    Abstract: The invention relates to a process for preparing a compound of general formula (Ia): wherein R2, Y, R4 and R5 are as defined herein, wherein the epoxidation is conducted using an oxidant and methyltrioxorhenium as a catalyst (MeReO3). The invention also relates to certain compounds per se. The compounds are intermediates in the synthesis of synthetic bile acids.
    Type: Application
    Filed: May 18, 2017
    Publication date: October 10, 2019
    Applicant: NZP UK Limited
    Inventors: Alexander Weymouth-Wilson, Zofia Komsta, Laura Wallis, Timothy Evans
  • Intermediates for the Synthesis of Bile Acid Derivatives, in Particular of Obeticholic Acid
    Publication number: 20190284227
    Abstract: The invention relates to compounds of general formula (I): wherein: , R1, R2, R3, R4, R5, R6 and Y are as defined herein. The compounds are intermediates in the synthesis of synthetic bile acids which are useful in the treatment of conditions such as liver disease.
    Type: Application
    Filed: May 18, 2017
    Publication date: September 19, 2019
    Applicant: NZP UK Limited
    Inventors: Alexander Weymouth-Wilson, Zofia Komsta, Laura Wallis, Timothy Evans, Ieuan Davies, Carl Otter, Rhys Batchelor
  • 6-alkyl-7-hydroxy-4-en-3-one steroids as intermediates for the production of steroidal FXR modulators
    Patent number: 10301350
    Abstract: The invention relates to compounds of formula (I) and related methods, wherein R1, R2, Y, R4 and R5 are as defined herein. The compounds are intermediates in the synthesis of synthetic bile acids with pharmacological activity. The invention futher provides intermediated in the systhesis of obeticholic acid and its analogues. The invention also provides methods related to the synthesizing of these intermediates and methods of preparing obeticholic acid and obeticholic acid analogues from the compound of the invention.
    Type: Grant
    Filed: November 19, 2015
    Date of Patent: May 28, 2019
    Assignee: NZP UK LIMITED
    Inventors: Alexander Weymouth-Wilson, Zofia Komsta, James Boydell, Carl Otter, Laura Wallis, Rhys Batchelor
  • Steroid 6.7.Beta.-Epoxides as Chemical Intermediates
    Publication number: 20190153023
    Abstract: The invention relates to a process for preparing a compound of general formula (Ia): wherein R2, Y, R4 and R5 are as defined herein. The invention also relates to certain compounds per se. The compounds are intermediates in the synthesis of synthetic bile acids.
    Type: Application
    Filed: May 18, 2017
    Publication date: May 23, 2019
    Applicant: NZP UK Limited
    Inventors: Alexander Weymouth-Wilson, Zofia Komsta, Laura Wallis, Ieuan Davies, Jingjing Wang
  • 6.Alpha.-Alkyl-6,7-Dione Steroids as Intermediates for the Production of Steroidal FXR Modulators
    Publication number: 20190077827
    Abstract: The invention relates to compounds of formula (I), wherein R1, R2, Y, R4 and R5b are as defined herein. The compounds are intermediates in the synthesis of synthetic bile acids.
    Type: Application
    Filed: October 17, 2018
    Publication date: March 14, 2019
    Applicant: NZP UK Limited
    Inventors: Alexander Weymouth-Wilson, Zofia Komsta, James Boydell, Laura Wallis, Carl Otter, Ieuan Davies, Rob Clarkson
  • 6.ALPHA.-ALKYL-3,7-DIONE STEROIDS AS INTERMEDIATES FOR THE PRODUCTION OF STEROIDAL FXR MODULATORS
    Publication number: 20180340006
    Abstract: The invention relates to compounds of formula (I) wherein R1, R2, Y1, R4 and R5 are as defined herein. The compounds are intermediates in the synthesis of synthetic bile acids.
    Type: Application
    Filed: November 19, 2015
    Publication date: November 29, 2018
    Inventors: Alexander WEYMOUTH-WILSON, Zofia KOMSTA, James BOYDELL, Laura WALLIS, Rhys BATCHELOR, Carl OTTER, Ieuan DAVIES
  • 5.beta.-6-alkyl-7-hydroxy-3-one steroids as intermediates for the production of steroidal FXR modulators
    Patent number: 10131688
    Abstract: The invention relates to compounds of formula (I): wherein R1, R2, Y, R4 and R5 are as defined herein. The compounds are intermediates in the synthesis of synthetic bile acids.
    Type: Grant
    Filed: November 19, 2015
    Date of Patent: November 20, 2018
    Assignee: NZP UK Limited
    Inventors: Alexander Weymouth-Wilson, Zofia Komsta, James Boydell, Laura Wallis, Nathan Bartlett, Montserrat Shelbourne
  • 6-ALKYL-7-HYDROXY-4-EN-3-ONE STEROIDS AS INTERMEDIATES FOR THE PRODUCTION OF STEROIDAL FXR
    Publication number: 20170327528
    Abstract: The invention relates to compounds of formula (I), wherein R1, R2, Y, R4 and R5 are as defined herein. The compounds are intermediates in the synthesis of synthetic bile acids.
    Type: Application
    Filed: November 19, 2015
    Publication date: November 16, 2017
    Inventors: Alexander WEYMOUTH-WILSON, Zofia KOMSTA, James BOYDELL, Carl OTTER, Laura WALLIS, Rhys BATCHELOR
  • 6.ALPHA.-ALKYL-6,7-DIONE STEROIDS AS INTERMEDIATES FOR THE PRODUCTION OF STEROIDAL FXR MODULATORS
    Publication number: 20170327531
    Abstract: The invention relates to compounds of formula (I), wherein R1, R2, Y, R4 and R5b are as defined herein. The compounds are intermediates in the synthesis of synthetic bile acids.
    Type: Application
    Filed: November 19, 2015
    Publication date: November 16, 2017
    Inventors: Alexander WEYMOUTH-WILSON, Zofia KOMSTA, James BOYDELL, Laura WALLIS, Carl OTTER, Ieuan DAVIES, Rob CLARKSON
  • 5.BETA.-6-ALKYL-7-HYDROXY-3-ONE STEROIDS AS INTERMEDIATES FOR THE PRODUCTION OF STEROIDAL FXR MODULATORS
    Publication number: 20170320907
    Abstract: The invention relates to compounds of formula (I): wherein R1, R2, Y, R4 and R5 are as defined herein. The compounds are intermediates in the synthesis of synthetic bile acids.
    Type: Application
    Filed: November 19, 2015
    Publication date: November 9, 2017
    Inventors: Alexander WEYMOUTH-WILSON, Zofia KOMSTA, James BOYDELL, Laura WALLIS, Nathan BARTLETT, Montserrat SHELBOURNE
  • TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY
    Publication number: 20100267961
    Abstract: Provided is a process for the preparation of 5-(ethylsulfonyl)-2-(naphthalen-2-yl) benzo[d]oxazole useful in the treatment of Duchenne muscular dystrophy.
    Type: Application
    Filed: August 14, 2008
    Publication date: October 21, 2010
    Inventors: Graham Wynne, Alexander Weymouth-Wilson, Robert Clarkson, Renate Van Well, Stephen Wren, Olivier De Moor
  • Steroid modified solatrioses
    Publication number: 20090012013
    Abstract: The invention pertains to steroid modified solatrioses and the synthesis thereof as well as to intermediate compounds useful for the synthesis of the steroid modified solatrioses.
    Type: Application
    Filed: July 8, 2004
    Publication date: January 8, 2009
    Inventors: Christopher Lawson, Alexander Weymouth-Wilson