Patents by Inventor Alexander Wrba

Alexander Wrba has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for producing erythropoietin containing no animal proteins
    Patent number: 6471500
    Abstract: A process for producing erythropoietin which is free of foreign animal proteins except for the proteins of the host cell, wherein DNA coding for EPO is expressed in a eukaryotic host cell and the host cell is cultured in a medium free of natural mammalian proteins. The erythropoietin is chromatographically purified using dye affinity chromatography, chromatography on hydroxyapatite, reversed phase chromatography, and anion exchange chromatography. The resulting preparation contains less than 100 ppm of proteins derived from the host cell, and less than 10 pg of host cell DNA per 83 &mgr;g erythropoietin.
    Type: Grant
    Filed: February 7, 2002
    Date of Patent: October 29, 2002
    Inventors: Josef Burg, Walter Schneider, Alexander Wrba, Werner Fürst, Karl-Heinz Sellinger
  • Process for producing erythropoietin containing no animal proteins
    Publication number: 20020146771
    Abstract: A process for producing erythropoietin which is free of foreign animal proteins except for the proteins of the host cell, wherein DNA coding for EPO is expressed in a eukaryotic host cell and the host cell is cultured in a medium free of natural mammalian proteins. The erythropoietin is chromatographically purified using dye affinity chromatography, chromatography on hydroxyapatite, reversed phase chromatography, and anion exchange chromatography. The resulting preparation contains less than 100 ppm of proteins derived from the host cell, and less than 10 pg of host cell DNA per 83 &mgr;g erythropoietin.
    Type: Application
    Filed: February 7, 2002
    Publication date: October 10, 2002
    Applicant: Roche Diagnostics GmbH
    Inventors: Josef Burg, Walter Schneider, Alexander Wrba, Werner Furst, Karl-Heinz Sellinger
  • Process for producing erythropoietin containing no animal proteins
    Patent number: 6399333
    Abstract: A process for producing erythropoietin which is free of foreign animal proteins except for the proteins of the host cell, wherein DNA coding for EPO is expressed in a eukaryotic host cell and the host cell is cultured in a medium free of natural mammalian proteins. The erythropoietin is chromatographically purified using dye affinity chromatography, chromatography on hydroxyapatite, reversed phase chromatography, and anion exchange chromatography. The resulting preparation contains less than 100 ppm of proteins derived from the host cell, and less than 10 pg of host cell DNA per 83 &mgr;g erythropoietin.
    Type: Grant
    Filed: February 13, 1998
    Date of Patent: June 4, 2002
    Assignee: Roche Diagnostics GmbH
    Inventors: Josef Burg, Walter Schneider, Alexander Wrba, Werner Fürst, Karl-Heinz Sellinger