Abstract: A method for placing a set of one or more markers in a luminal network in a patient's body, the method comprising using at least one hardware processor for: receiving image data of the anatomy of a luminal network of a patient and a location of at least one target in said luminal network anatomy; obtaining a rule set defining one or more rules for placing said set of one or more markers in said luminal network anatomy and with respect to said at least one target; during a survey performed by a user via a navigation system in a portion of the luminal network surrounding said at least one target, acquiring, via said navigation system, sample-locations in the surveyed portion of the luminal network; and identifying a set of one or more marker locations for placing said set of one or more markers from said acquired sample-locations, which complies with said rule set.