Abstract: A system includes a processor to: receive a description of a current decision that includes selecting an option; repeatedly display the description; for each option, receive an indication of selection of scale text specifying a degree of intensity or intensity for achieving or avoiding a possible outcome of the option, and derive an overall motivation based on the at least one selection; identify a best option based on the overall motivations; display the best option; compare the overall motivation of the best option to a threshold; in response to being less than the threshold, display a warning and a prompt for the operator to further consider the current decision; compare the overall motivation of the best option to the others; and in response to not exceeding all other overall motivations, by at least a threshold of difference, present a proximity warning and the prompt.

Abstract: A system includes a processor to: receive a description of a current decision that includes selecting an option; repeatedly display the description; for each option, receive an indication of selection of scale text specifying a degree of intensity or intensity for achieving or avoiding a possible outcome of the option, and derive an overall motivation based on the at least one selection; identify a best option based on the overall motivations; display the best option; compare the overall motivation of the best option to a threshold; in response to being less than the threshold, display a warning and a prompt for the operator to further consider the current decision; compare the overall motivation of the best option to the others; and in response to not exceeding all other overall motivations, by at least a threshold of difference, present a proximity warning and the prompt.

Abstract: A system includes a processor to: receive a description of a current decision that includes selecting an option; repeatedly display the description; for each option, receive an indication of selection of scale text specifying a degree of intensity or intensity for achieving or avoiding a possible outcome of the option, and derive an overall motivation based on the at least one selection; identify a best option based on the overall motivations; display the best option; compare the overall motivation of the best option to a threshold; in response to being less than the threshold, display a warning and a prompt for the operator to further consider the current decision; compare the overall motivation of the best option to the others; and in response to not exceeding all other overall motivations, by at least a threshold of difference, present a proximity warning and the prompt.

Abstract: A system includes a processor to: receive a description of a current decision that includes selecting an option; repeatedly display the description; for each option, receive an indication of selection of scale text specifying a degree of intensity or intensity for achieving or avoiding a possible outcome of the option, and derive an overall motivation based on the at least one selection; identify a best option based on the overall motivations; display the best option; compare the overall motivation of the best option to a threshold; in response to being less than the threshold, display a warning and a prompt for the operator to further consider the current decision; compare the overall motivation of the best option to the others; and in response to not exceeding all other overall motivations, by at least a threshold of difference, present a proximity warning and the prompt.

Abstract: Disclosed are methods and pharmaceutical compositions for modulating one or more steroidal receptor activities. The methods typically utilize and the pharmaceutical compositions typically include one or more substituted phenyl aziridine precursors, their respective aziridines, analogs thereof, derivatives thereof, or pharmaceutically acceptable salts thereof such as CpdA. The methods and compositions may be used for treating diseases, disorders, and conditions associated with glucocorticoid receptor activity, androgen receptor activity, or both, such as cancers, acne vulgaris, and alopecia.

Abstract: Disclosed are methods and pharmaceutical compositions for modulating one or more steroidal receptor activities. The methods typically utilize and the pharmaceutical compositions typically include one or more substituted phenyl aziridine precursors, their respective aziridines, analogs thereof, derivatives thereof, or pharmaceutically acceptable salts thereof such as CpdA. The methods and compositions may be used for treating diseases, disorders, and conditions associated with glucocorticoid receptor activity, androgen receptor activity, or both, such as cancers, acne vulgaris, and alopecia.

Abstract: Disclosed are methods and pharmaceutical compositions for modulating one or more steroidal receptor activities. The methods typically utilize and the pharmaceutical compositions typically include one or more substituted phenyl aziridine precursors, their respective aziridines, analogs thereof, derivatives thereof, or pharmaceutically acceptable salts thereof such as CpdA. The methods and compositions may be used for treating diseases, disorders, and conditions associated with glucocorticoid receptor activity, androgen receptor activity, or both, such as cancers, acne vulgaris, and alopecia.

Abstract: Disclosed are methods and pharmaceutical compositions for modulating one or more steroidal receptor activities. The methods typically utilize and the pharmaceutical compositions typically include one or more substituted phenyl aziridine precursors, their respective aziridines, analogs thereof, derivatives thereof, or pharmaceutically acceptable salts thereof such as CpdA. The methods and compositions may be used for treating diseases, disorders, and conditions associated with glucocorticoid receptor activity, androgen receptor activity, or both, such as cancers, acne vulgaris, and alopecia.

Abstract: Disclosed are methods and pharmaceutical compositions for treating diseases, disorders, and conditions associated with glucocorticoid receptor (GR) expression and activity. The disclosed methods typically include administering to a patient in need thereof a proteasome inhibitor and administering to the patient in need thereof a glucocorticoid receptor (GR) agonist, either before, concurrently with, or after the proteasome inhibitor is administered.

Abstract: Disclosed are methods and pharmaceutical compositions for modulating one or more steroidal receptor activities. The methods typically utilize and the pharmaceutical compositions typically include one or more substituted phenyl aziridine precursors, their respective aziridines, analogs thereof, derivatives thereof, or pharmaceutically acceptable salts thereof such as CpdA. The methods and compositions may be used for treating diseases, disorders, and conditions associated with glucocorticoid receptor activity, androgen receptor activity, or both, such as cancers, acne vulgaris, and alopecia.

Abstract: Disclosed are methods and pharmaceutical compositions for modulating one or more steroidal receptor activities. The methods typically utilize and the pharmaceutical compositions typically include one or more substituted phenyl aziridine precursors, their respective aziridines, analogs thereof, derivatives thereof, or pharmaceutically acceptable salts thereof such as CpdA. The methods and compositions may be used for treating diseases, disorders, and conditions associated with glucocorticoid receptor activity, androgen receptor activity, or both, such as cancers, acne vulgaris, and alopecia.