Patents by Inventor Alexander Zaydenberg

Alexander Zaydenberg has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PURIFICATION OF FVIII FROM PLASMA USING SILICON OXIDE ADSORPTION
    Publication number: 20220380439
    Abstract: Efficient methods for capture and removal of fibrinogen from blood plasma fractions, especially cryoprecipitate, and Fraction II+III providing high yields of blood coagulation Factor VIII are disclosed. According to this disclosure, there is provided a method of separating plasma cryoprecipitate or Fraction II+III comprising a blood coagulation factor and fibrinogen into a first fraction comprising the blood coagulation factor and a second fraction containing the fibrinogen, the method comprising: (a) contacting he plasma cryoprecipitate with solid SiO2 or Al(OH)3, thereby adsorbing the fibrinogen onto the solid SiO2 or Al(OH)3; and (b) separating the fibrinogen adsorbed onto the solid SiO2 or Al(OH)3 from the blood factor, thereby forming the first fraction and the second fraction.
    Type: Application
    Filed: December 20, 2021
    Publication date: December 1, 2022
    Inventors: Hany Anwar Hassouna, Joshua Elliot Yu, Alexander Zaydenberg, Ani Der-Sarkissian, Yasser Badour, Emily Vincent, Patrick D. Gavit
  • PLASMA FRACTIONATION UTILIZING SPRAY-DRIED HUMAN PLASMA
    Publication number: 20220106357
    Abstract: The present invention provides a method of fractionating human plasma, in some embodiments, using the Cohn fractionation procedure. The improvement comprises the use of physiologically active reconstituted spray dried human plasma as the starting material for the fractionation procedure.
    Type: Application
    Filed: October 1, 2021
    Publication date: April 7, 2022
    Inventors: Zhorzh Patatanyan, Rohit Murthy, Yasser Baddour, Alexander Zaydenberg
  • Purification of butyrylcholinesterase using membrane adsorption
    Patent number: 9783792
    Abstract: The present invention relates to purification of butyrylcholinesterase using anion exchange material, where the butyrylcholinesterase content is enriched at least 10 fold per total protein in the composition.
    Type: Grant
    Filed: November 12, 2009
    Date of Patent: October 10, 2017
    Assignees: Baxalta Incorporated, Baxalta GmbH
    Inventors: Alexander Zaydenberg, Susan Weber, Patrick Gavit, Laura Lei, Wolfgang Teschner, Harald A. Butterweck, Ursula Mais-Paul, Hans-Peter Schwarz
  • Real time monitoring and control of protein production processes using impedance spectroscopy
    Patent number: 9643998
    Abstract: Methods and systems for monitoring and/or controlling protein separation, purification, extraction, and/or fractionation processes are provided. The impedance of a protein mixture undergoing a protein process is measured and compared to a target reference impedance value or range of reference impedance values. If the measured impedance is not within an acceptable deviation of the target reference impedance value, a parameter of the protein mixture or process is adjusted.
    Type: Grant
    Filed: December 9, 2011
    Date of Patent: May 9, 2017
    Assignees: BAXALTA GMBH, BAXALTA INCORPORATED
    Inventors: Cary N. Wauters, Alexander Zaydenberg
  • Real time monitoring and control of protein production processes using impedance spectroscopy
    Patent number: 9200031
    Abstract: Methods and systems for monitoring and/or controlling protein separation, purification, extraction, and/or fractionation processes are provided. The impedance of a protein mixture undergoing a protein process is measured and compared to a target reference impedance value or range of reference impedance values. If the measured impedance is not within an acceptable deviation of the target reference impedance value, a parameter of the protein mixture or process is adjusted.
    Type: Grant
    Filed: December 9, 2011
    Date of Patent: December 1, 2015
    Assignees: Baxalta GmbH, Baxalta Incorporated
    Inventors: Cary N. Wauters, Alexander Zaydenberg
  • Real Time Monitoring and Control of Protein Production Processes Using Impedance Spectroscopy
    Publication number: 20120153221
    Abstract: Methods and systems for monitoring and/or controlling protein separation, purification, extraction, and/or fractionation processes are provided. The impedance of a protein mixture undergoing a protein process is measured and compared to a target reference impedance value or range of reference impedance values. If the measured impedance is not within an acceptable deviation of the target reference impedance value, a parameter of the protein mixture or process is adjusted.
    Type: Application
    Filed: December 9, 2011
    Publication date: June 21, 2012
    Applicants: Baxter Healthcare S.A., Baxter International, Inc.
    Inventors: Cary N. Wauters, Alexander Zaydenberg
  • PURIFICATION OF BUTYRYLCHOLINESTERASE USING MEMBRANE ADSORPTION
    Publication number: 20100226907
    Abstract: The present invention relates to purification of butyrylcholinesterase using anion exchange material, where the butyrylcholinesterase content is enriched at least 10 fold per total protein in the composition.
    Type: Application
    Filed: November 12, 2009
    Publication date: September 9, 2010
    Applicants: Baxter International Inc., Baxter Healthcare S.A.
    Inventors: Alexander Zaydenberg, Susan Weber, Patrick Gavit, Laura Lei, Wolfgang Teschner, Harald A. Butterweck, Ursula Mais-Paul, Hans-Peter Schwarz