Abstract: To increase the efficiency of electronic design automation, at an end point of physical design synthesis optimization flow for a putative integrated circuit design having a plurality of nets, identify at least one congested region in the putative integrated circuit design. Identify those of the nets of the putative integrated circuit design traversing through the at least one congested region, to obtain a plurality of candidate nets for demotion. Demote a plurality of selected nets, selected from the plurality of candidate nets for demotion, from an upper routing layer of the putative integrated circuit design to a lower routing layer of the putative integrated circuit design. At least some of the plurality of selected nets experience a loss of timing quality of result after the demoting.

Abstract: Provided herein are immune cells and methods of use, wherein the immune cells include a chimeric antigen receptor (CAR), wherein the CAR comprises an extracellular antigen binding domain that binds specifically to a first epitope; and an inhibitory chimeric antigen receptor (iCAR), wherein the iCAR comprises an extracellular antigen binding domain that binds specifically to a second epitope, wherein the immune cell is activated when the immune cells binds to the first epitope and does not bind to the second epitope; and wherein the immune cell is inactivated when the immune cell binds to the first and second epitopes.

Abstract: This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) having core structure (I), pharmaceutical compositions containing at least one such modulator, methods of treatment of CFTR mediated diseases, including cystic fibrosis, using such modulators and pharmaceutical compositions, combination pharmaceutical compositions and combination therapies employing those modulators, and processes and intermediates for making such modulators.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for estimating a 3-D pose of an object of interest from image and point cloud data. In one aspect, a method includes obtaining an image of an environment; obtaining a point cloud of a three-dimensional region of the environment; generating a fused representation of the image and the point cloud; and processing the fused representation using a pose estimation neural network and in accordance with current values of a plurality of pose estimation network parameters to generate a pose estimation network output that specifies, for each of multiple keypoints, a respective estimated position in the three-dimensional region of the environment.

Abstract: This disclosure provides systems, methods, and apparatus related to an ultrasonic microphone and an ultrasonic acoustic radio. In one aspect a system includes a transmitter and a receiver. The receiver comprises a membrane. The membrane comprises a single layer or multiple layers of a two-dimensional material. The receiver is operable to receive sound waves in a frequency range, with the frequency range being the ultrasonic frequency range.

Abstract: The present invention refers to a process for the asymmetric synthesis of isopiperitenol and successor compounds.

Abstract: Reducing power consumption in an electronic device can include analyzing device usage data associated with the device to predict an extended period of user inactivity, the usage data including at least one of historical usage data and present usage signals and entering an enhanced reduced power state by implementing one or more power saving optimizations for at least a portion the extended period of extended user inactivity, the one or more power saving optimizations slowing, delaying, or interrupting one or more normal activities normally performed by the device. The method can further include exiting the enhanced reduced power state by suspending the one or more power saving optimizations. Exiting the enhanced reduced power state can be performed in response to at least one of: user activity; a specified user routine; or a time predicted by the analyzing device usage data.

Abstract: A modular connection board and a method for connecting a modular connection board to a group of electricity storage elements each including electrode terminals. The modular connection board includes at least two connection board modules each having a bracket including a plurality of connection member mounting portions. Connection members are mounted in the connection member mounting portions to connect the electrode terminals of adjacent electricity storage elements to each other. A circuit board supporting portion is arranged on the bracket and receives a circuit board. Between adjacent connection board modules is an interface extending in a second direction, and which comprises a joint for joining the two adjacent connection board modules.

Abstract: This disclosure provides systems, methods, and apparatus related to an ultrasonic microphone and an ultrasonic acoustic radio. In one aspect a system includes a transmitter and a receiver. The receiver comprises a membrane. The membrane comprises a single layer or multiple layers of a two-dimensional material. The receiver is operable to receive sound waves in a frequency range, with the frequency range being the ultrasonic frequency range.

Abstract: The present disclosure provides a light bulb speaker system. The light bulb speaker system includes a housing having an open end and a partially closed end. A coaxial main speaker is positioned proximal to the open end, a first assistant speaker and a second assistant speaker are positioned between the open end and the partially closed end within the housing. The first and second assistant speakers are mounted so that they face perpendicular to a central axis of the light bulb speaker. The system also includes a light source component mounted within an annular frame, the light source proximally mounted within the housing towards the open end. The housing includes a plurality of speaker holes positioned on opposing sides so that the first and the second assistant speaker are configured to align with the plurality of the speaker holes.

Abstract: A method of statistical machine translation (SMT) is provided. The method comprises generating reordering knowledge based on the syntax of a source language (SL) and a number of alignment matrices that map sample SL sentences with sample target language (TL) sentences. The method further comprises receiving a SL word string and parsing the SL word string into a parse tree that represents the syntactic properties of the SL word string. The nodes on the parse tree are reordered based on the generated reordering knowledge in order to provide reordered word strings. The method further comprises translating a number of reordered word strings to create a number of TL word strings, and identifying a statistically preferred TL word string as a preferred translation of the SL word string.