Patents by Inventor Alexandr Dmitrievich Isaev

Alexandr Dmitrievich Isaev has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9745337
    Abstract: The invention relates to the development of drugs intended for the prophylaxis and/or treatment of viral diseases caused, in particular, by herpes viruses. What are proposed are complex compounds of germanium having the general structural formula: Gex[AD][CA]y[AA]2 ??(1), where AD is a derivative of a nitrogenous base of the purine series that has antiviral activity and can be selected from guanine derivatives, such as acyclovir, valacyclovir, gancyclovir and pencyclovir, or from adenine derivatives, such as vidarabine; CA is a hydroxycarboxylic acid which can be selected from acids such as (but not limited to) citric acid, lactic acid and malic acid; AA is an amino acid which can be selected from various a-amino acids, such as arginine, gylcine, lysine and threonine, and where x=1-2, y=2-4 and z=0-2. Complex compounds of germanium have a high level of antiviral and immune-stimulating activity and are readily soluble in water.
    Type: Grant
    Filed: November 1, 2012
    Date of Patent: August 29, 2017
    Assignee: OBSCHESNO S OGRANICHENNOI OTVETSTVENNOSTYU “WDS FARMA”
    Inventors: Alexandr Dmitrievich Isaev, Igor Valerievich Ambrosov, Tamaz Omarovich Manasherov, Svetlana Konstantinovna Matelo
  • Patent number: 9546188
    Abstract: The invention relates to complexes of germanium with amino acids and carboxylic acids of the general formula Ge[OH]a[AA]b[CA]c (I), where AA is an amino acid, CA is a carboxylic acid, a=0÷3, b=1÷3, c=0÷3, and 1?b+c?4, wherein AA and AC in the complex can be identical or different, and to a method for preparing same. The method consists in preparing an aqueous suspension of germanium dioxide, adding an amino acid and a carboxylic acid to the aqueous suspension of germanium oxide produced, heating the mixture produced with agitation at a temperature of 40-100° C. for 2-14 hours with subsequent filtering, removal of the water and production of a complex in solid form. The method makes it possible to prepare stable complexes with a controllable composition and a controllable ratio of germanium to amino acid and carboxylic acid which are stable in solid form and can be used in medicine.
    Type: Grant
    Filed: November 9, 2012
    Date of Patent: January 17, 2017
    Assignee: OBSCHESNO S OGRANICHENNOI OTVETSTVENNOSTYU “WDS FARMA”
    Inventors: Alexandr Dmitrievich Isaev, Tamaz Omarovich Manasherov, Igor Valerievich Ambrosov, Svetlana Konstantinovna Matelo
  • Publication number: 20150126726
    Abstract: The invention relates to the development of drugs intended for the prophylaxis and/or treatment of viral diseases caused, in particular, by herpes viruses. What are proposed are complex compounds of germanium having the general structural formula: Gex[AD][CA]y[AA]z??(I), where AD is a derivative of a nitrogenous base of the purine series that has antiviral activity and can be selected from guanine derivatives, such as acyclovir, valacyclovir, gancyclovir and pencyclovir, or from adenine derivatives, such as vidarabine; CA is a hydroxycarboxylic acid which can be selected from acids such as (but not limited to) citric acid, lactic acid and malic acid; AA is an amino acid which can be selected from various a-amino acids, such as arginine, glycine, lysine and threonine, and where x=1-2, y=2-4 and z=0-2. Complex compounds of germanium have a high level of antiviral and immune-stimulating activity and are readily soluble in water.
    Type: Application
    Filed: November 1, 2012
    Publication date: May 7, 2015
    Applicant: OBSCHESTVO S OGRANICHENNOI OTVETSTVENNOSTYU "WDS FARMA"
    Inventors: Alexandr Dmitrievich Isaev, Igor Valerievich Ambrosov, Tamaz Omarovich Manasherov, Svetlana Konstantinovna Matelo
  • Publication number: 20150011523
    Abstract: The invention relates to complexes of germanium with amino acids and carboxylic acids of the general formula Ge[OH]a[AA]b[CA]c (I), where AA is an amino acid, CA is a carboxylic acid, a=0-3, b=1-3, c=0-3, and 1<b+c?4, wherein AA and AC in the complex can be identical or different, and to a method for preparing same. The method preparing an aqueous suspension of germanium dioxide, adding an amino acid and a carboxylic acid to the aqueous suspension of germanium oxide produced, heating the mixture produced with agitation at a temperature of 40-100° C. for 2-14 hours with subsequent filtering, removal of the water and production of a complex in solid form. The method makes it possible to prepare stable complexes with a controllable composition and a control fable ratio of germanium to amino acid and carboxylic acid which are stable in solid form and can be used in medicine.
    Type: Application
    Filed: November 9, 2012
    Publication date: January 8, 2015
    Inventors: Alexandr Dmitrievich Isaev, Tamaz Omarovich Manasherov, Igor Valerievich Ambrosov, Svetlana Konstantinovna Matelo