Abstract: 5-(w-Aminoacyl)-5,10-dihydro-11H-dibenzo(b,e)(1,4)-diazepine-11-ones, and their preparation are disclosed for treatment of antiarrhythmia and as an anticholinergic drug.

Abstract: 1,2,3,4-Tetrahydropyrrolo-[1,2-a]-pyrazine of the formula: ##STR1## is disclosed together with a method for preparing the same which comprises reducing 3,4-dihydropyrrolo-[1,2-a]-pyrazine, in a medium of an organic solvent, by way of hydrogenation with hydrogen or complex hydrides of metals. When using hydrogen said hydrogenation is effected in the presence of a catalyst of the group of platinum. The desired product is then isolated from the reaction mixture. The resulting 1,2,3,4-tetrahydropyrrolo-[1,2-a]-pyrazine may be used as the starting product for the synthesis of physiologically active compounds such as octahydropyrrolo-[1,2-a]-pyrazine which serves as the basis for the preparation of coronary-dilating and neuroleptic compounds. The method for preparing 1,2,3,4-tetrahydropyrrolo-[1,2-a]-pyrazine is technologically simple and may be readily implemented on a commercial scale.

Abstract: The novel compound according to the present invention, viz. 3,4-dihydropyrrolo-[1,2-a]-pyrazine has the formula: ##STR1## The method of preparing this compound comprises reacting dialkylacetals or dioxalane of a 2,5-dialkoxytetrahydrofurfurol with ethylenediamine in a medium of lower aliphatic acids at a temperature within the range of from 100.degree. to 150.degree. C., followed by isolation of the desired product.The novel compound according to the present invention, viz. 3,4-dihydropyrrolo-[1,2-a]-pyrazine, owing to a simple method for producing same, simplifies the process of manufacture of physiologically active compounds employed in neuroleptic or coronary dilating preparations, wherein it may be used as the starting material.