Patents by Inventor Alexandr V. Maximenko

Alexandr V. Maximenko has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Urokinase derivatives covalently bound to fibrinogen
    Patent number: 4564596
    Abstract: Urokinase derivatives comprise urokinase covalently bonded with fibrinogen or urokinase covalently bonded with fibrinogen through an aliphatic diamine and correspond to the general formula: ##STR1## wherein P is fibrinogen, E is urokinase, R is absent or stands for ##STR2## wherein n is 1-12, with a molecular mass of from 360,000 to 440,000 D, a content of protein of 10 to 30% by mass, an esterase catalytic activity of 30-60%.These derivatives have an increased affinity to fibrin and feature a prolonged fibrinolytic effect.
    Type: Grant
    Filed: January 3, 1985
    Date of Patent: January 14, 1986
    Inventors: Alexandr V. Maximenko, Elena G. Tischenko, Vladimir P. Torchilin, Vladimir N. Smirnov, Evgeny I. Chazov
  • Heat-resistant water soluble urokinase derivative
    Patent number: 4349630
    Abstract: A heat-resistant water soluble derivative of urokinase is prepared which comprises urokinase covalently bonded to a copolymer of acrylamide and acrylic acid having a molecular weight of 10,000 to 200,000 and a content of acrylic acid of 1% to 2%. The derivative contains 15% to 35% urokinase and has an esterase and amidolytic activity of from 10% to 80%.
    Type: Grant
    Filed: August 27, 1980
    Date of Patent: September 14, 1982
    Inventors: Alexandr V. Maximenko, Vladimir P. Torchilin, Vladimir N. Smirnov, Evgeny I. Chazov