Patents by Inventor Alexandra E. Briner

Alexandra E. Briner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and compositions for sequence guiding Cas9 targeting
    Patent number: 10787654
    Abstract: The present invention is directed to methods and compositions for genome editing and DNA targeting of proteins.
    Type: Grant
    Filed: January 23, 2015
    Date of Patent: September 29, 2020
    Assignee: NORTH CAROLINA STATE UNIVERSITY
    Inventors: Rodolphe Barrangou, Kurt M. Selle, Alexandra E. Briner
  • Compositions and methods related to a type-II CRISPR-Cas system in
    Patent number: 10584358
    Abstract: The present invention is directed to methods and compositions for typing of Lactobacillus buchneri bacterial strains, detecting the presence of a L. buchneri in a sample, identifying a strain of L. buchneri having resistance to an invasive foreign genetic element, modifying the resistance of bacteria and archeae to an invasive foreign genetic element, and introducing nicks into or cleaving double stranded DNA for genome editing.
    Type: Grant
    Filed: October 29, 2014
    Date of Patent: March 10, 2020
    Assignee: NORTH CAROLINA STATE UNIVERSITY
    Inventors: Rodolphe Barrangou, Alexandra E. Briner
  • Cas9 proteins and guiding features for DNA targeting and genome editing
    Patent number: 10450584
    Abstract: The present invention is directed to methods and compositions comprising novel CRISPR polypeptides and polynucleotides for site-specific cleavage and nicking of nucleic acids, transcriptional control and genome editing.
    Type: Grant
    Filed: August 27, 2015
    Date of Patent: October 22, 2019
    Assignee: NORTH CAROLINA STATE UNIVERSITY
    Inventors: Rodolphe Barrangou, Alexandra E. Briner
  • NOVEL CAS9 PROTEINS AND GUIDING FEATURES FOR DNA TARGETING AND GENOME EDITING
    Publication number: 20170275648
    Abstract: The present invention is directed to methods and compositions comprising novel CRISPR polypeptides and polynucleotides for site-specific cleavage and nicking of nucleic acids, transcriptional control and genome editing.
    Type: Application
    Filed: August 27, 2015
    Publication date: September 28, 2017
    Inventors: Rodolphe Barrangou, Alexandra E. Briner
  • Methods and Compositions for Sequences Guiding Cas9 Targeting
    Publication number: 20170002339
    Abstract: The present invention is directed to methods and compositions for genome editing and DNA targeting of proteins.
    Type: Application
    Filed: January 23, 2015
    Publication date: January 5, 2017
    Inventors: Rodolphe BARRANGOU, Kurt M. SELLE, Alexandra E. BRINER
  • COMPOSITIONS AND METHODS RELATED TO A TYPE-II CRISPR-CAS SYSTEM IN LACTOBACILLUS BUCHNERI
    Publication number: 20160289700
    Abstract: The present invention is directed to methods and compositions for typing of Lactobacillus buchneri bacterial strains, detecting the presence of a L. buchneri in a sample, identifying a strain of L. buchneri having resistance to an invasive foreign genetic element, modifying the resistance of bacteria and archeae to an invasive foreign genetic element, and introducing nicks into or cleaving double stranded DNA for genome editing.
    Type: Application
    Filed: October 29, 2014
    Publication date: October 6, 2016
    Inventors: Rodolphe Barrangou, Alexandra E. Briner