Patents by Inventor Alexandra Grier

Alexandra Grier has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Enhancing endonuclease based gene editing in primary cells
    Patent number: 10563226
    Abstract: Disclosed herein are nuclease-based systems for genome editing and methods of using the system for genome editing. Also, disclosed are approaches to enhance Cas9-mediated gene editing efficiency in primary human cells with minimal toxicity when using adeno-associated virus vectors (AAV) to express the guide RNAs necessary for CRISPR/Cas9-based genome editing in the presence of helper proteins.
    Type: Grant
    Filed: May 12, 2016
    Date of Patent: February 18, 2020
    Assignee: Seattle Children's Hospital
    Inventors: Andrew Scharenberg, David Rawlings, Michael C. Jensen, Kamila Gwiazda, Alexandra Grier
  • ENHANCING ENDONUCLEASE BASED GENE EDITING IN PRIMARY CELLS
    Publication number: 20180119174
    Abstract: Disclosed herein are nuclease-based systems for genome editing and methods of using the system for genome editing. Also, disclosed are approaches to enhance Cas9-mediated gene editing efficiency in primary human cells with minimal toxicity when using adeno-associated virus vectors (AAV) to express the guide RNAs necessary for CRISPR/Cas9-based genome editing in the presence of helper proteins.
    Type: Application
    Filed: May 12, 2016
    Publication date: May 3, 2018
    Inventors: Andrew Scharenberg, David Rawlings, Michael C. Jensen, Kamila Sabina Gwiazda, Alexandra Grier
  • ENHANCING ENDONUCLEASE BASED GENE EDITING IN PRIMARY CELLS
    Publication number: 20160333377
    Abstract: Disclosed herein are nuclease-based systems for genome editing and methods of using the system for genome editing. Also, disclosed are approaches to enhance Cas9-mediated gene editing efficiency in primary human cells with minimal toxicity when using adeno-associated virus vectors (AAV) to express the guide RNAs necessary for CRISPR/Cas9-based genome editing in the presence of helper proteins.
    Type: Application
    Filed: May 12, 2016
    Publication date: November 17, 2016
    Inventors: Andrew Scharenberg, David Rawlings, Michael C. Jensen, Kamila Gwiazda, Alexandra Grier