Abstract: Techniques for predicting synthetic lethality in a first species using experimentally derived interactions from at least a second species. An example method can include generating a first biological network for the first species and a second biological network for the second species that include node information representing genes and edge information representing physical interactions between gene-protein products. The method can include determining and normalizing one or more network parameters to permit comparisons between the first and second biological networks. The method can further include training a synthetic lethality model with the experimentally derived synthetic lethality data and applying the synthetic lethality model to the first biological network to predict one or more synthetic lethality pairs.