Patents by Inventor Alexandra Lerchner

Alexandra Lerchner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Oxidation and amination of primary alcohols
    Patent number: 9580732
    Abstract: A method including the steps a) providing a primary alcohol of the formula HO—(CH2)x—R1, where R1 is —OH, —SH, —NH2 or —COOR2; x is at least 3; and R2 is H, alkyl or aryl, b) oxidizing the primary alcohol by contacting it with an NAD(P)+-dependent alcohol dehydrogenase, and c) contacting the oxidation product of step a) with a transaminase, where the NAD(P)+-alcohol dehydrogenase and/or the transaminase is a recombinant or isolated enzyme. A whole cell catalyst for carrying out the method. The use of such a whole cell catalyst for oxidizing a primary alcohol.
    Type: Grant
    Filed: July 17, 2012
    Date of Patent: February 28, 2017
    Assignee: Evonik Degussa GmbH
    Inventors: Markus Pötter, Thomas Haas, Jan Christoph Pfeffer, Arne Skerra, Wolfgang Kroutil, Alexandra Lerchner, Johann H. Sattler, Steffen Schaffer, Katharina Christin Tauber
  • NADP-DEPENDENT ALANINE DEHYDROGENASE
    Publication number: 20150099282
    Abstract: The present invention relates to a polypeptide comprising the amino acid sequence of the Bacillus subtilis alanine dehydrogenase or a variant thereof, where Leu197 or an amino acid which is located at a homologous position in the amino acid sequence is exchanged for an amino acid with a positively charged side chain, to a nucleic acid molecule encoding such a polypeptide, and to a process for the production of alanine or a compound generated with consumption of alanine, comprising the step of reacting pyruvate with ammonium and NADPH to give alanine by bringing the pyruvate into contact with the polypeptide according to the invention or with the cell according to the invention.
    Type: Application
    Filed: April 16, 2013
    Publication date: April 9, 2015
    Applicant: EVONIK INDUSTRIES AG
    Inventors: Thomas Haas, Jan Christoph Pfeffer, Arne Skerra, Alexandra Lerchner, Alexander Jarasch
  • OXIDATION AND AMINATION OF SECONDARY ALCOHOLS
    Publication number: 20140308717
    Abstract: The present invention relates to a method comprising the steps a) providing a secondary alcohol, b) oxidizing the secondary alcohol by contacting it with an NAD(P)+-dependent alcohol dehydrogenase and c) contacting the oxidation product of step a) with a transaminase, wherein the NAD(P)+-dependent alcohol dehydrogenase and/or the transaminase is a recombinant or isolated enzyme, to a whole cell catalyst for carrying out the method, and to the use of such a whole cell catalyst for oxidizing a secondary alcohol.
    Type: Application
    Filed: July 27, 2012
    Publication date: October 16, 2014
    Applicant: Evonik Degussa GmbH
    Inventors: Thomas Haas, Markus Poetter, Jan Christoph Pfeffer, Wolfgang Kroutil, Arne Skerra, Alexandra Lerchner, Katharina Christin Tauber, Johann H. Sattler, Steffen Schaffer
  • Method for producing multicyclical ring systems carrying amino groups
    Patent number: 8841096
    Abstract: The invention relates to a method for the amination of at least one keto group in a multicyclic ring system comprising at least one keto group into an amino group, using at least one enzyme E having transaminase activity.
    Type: Grant
    Filed: January 13, 2010
    Date of Patent: September 23, 2014
    Assignee: Evonik Degussa GmbH
    Inventors: Volker Sieber, Katrin Grammann, Broder Ruehmann, Thomas Haas, Jan Christoph Pfeffer, Kai Doderer, Claudia Rollmann, Arne Skerra, Christian Rausch, Alexandra Lerchner
  • OXIDATION AND AMINATION OF PRIMARY ALCOHOLS
    Publication number: 20140242646
    Abstract: The present invention relates to a method comprising the steps a) providing a primary alcohol of the formula HO—(CH2)x—R1, wherein R1 is selected from the group consisting of —OH, —SH, —NH2 and —COOR2, x is at least 3 and R2 is selected from the group consisting of H, alkyl and aryl, b) oxidizing the primary alcohol by contacting it with an NAD(P)+-dependent alcohol dehydrogenase, and c) contacting the oxidation product of step a) with a transaminase, wherein the NAD(P)+-alcohol dehydrogenase and/or the transaminase is a recombinant or isolated enzyme, to a whole cell catalyst for carrying out the method, and to the use of such a whole cell catalyst for oxidizing a primary alcohol.
    Type: Application
    Filed: July 17, 2012
    Publication date: August 28, 2014
    Applicant: EVONIK DEGUSSA GmbH
    Inventors: Markus Pötter, Thomas Haas, Jan Christoph Pfeffer, Arne Skerra, Wolfgang Kroutil, Alexandra Lerchner, Johann H. Sattler, Steffen Schaffer, Katharina Christin Tauber
  • METHOD FOR PRODUCING MULTICYCLICAL RING SYSTEMS CARRYING AMINO GROUPS
    Publication number: 20120041216
    Abstract: The invention relates to a method for the amination of at least one keto group in a multicyclic ring system comprising at least one keto group into an amino group, using at least one enzyme E having transaminase activity.
    Type: Application
    Filed: January 13, 2010
    Publication date: February 16, 2012
    Applicant: EVONIK DEGUSSA GmbH
    Inventors: Volker Sieber, Katrin Grammann, Broder Ruehmann, Thomas Haas, Jan Christoph Pfeffer, Kai Doderer, Claudia Rollmann, Arne Skerra, Christian Rausch, Alexandra Lerchner