Patents by Inventor Alexandra Rose GRASSIAN

Alexandra Rose GRASSIAN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of treating cancer by inhibiting SETD2
    Patent number: 11952572
    Abstract: The present disclosure provides methods and pharmaceutical compositions for treating or slowing the progression of cancer, i.e., pancreatic cancer or esophageal cancer, by administering to a human subject in need thereof a therapeutically effective amount of an inhibitor of the histone methyltransferase, SETD2.
    Type: Grant
    Filed: August 14, 2018
    Date of Patent: April 9, 2024
    Assignee: Epizyme, Inc.
    Inventors: Alexandra Rose Grassian, Michael Thomenius, Jennifer Anne Totman
  • INHIBITION OF SMARCA2 FOR TREATMENT OF CANCER
    Publication number: 20230000849
    Abstract: The present disclosure provides treatment modalities, e.g., strategies, treatment methods, patient stratification methods, combinations, and compositions that are useful for the treatment of disorders, e.g., proliferative disorders, such as certain cancer. Some aspects of this disclosure provide treatment modalities, methods, strategies, compositions, combinations, and dosage forms for the treatment of cell proliferative disorders, e.g., cancers with decreased activity or function, or loss of function, of SMARCA4 with a SMARCA2 antagonist.
    Type: Application
    Filed: June 24, 2022
    Publication date: January 5, 2023
    Inventors: Alexandra Rose GRASSIAN, Allison DREW
  • Methods Of Treating Cancer By Inhibiting SETD2
    Publication number: 20210002645
    Abstract: The present disclosure provides methods and pharmaceutical compositions for treating or slowing the progression of cancer, i.e., pancreatic cancer or esophageal cancer, by administering to a human subject in need thereof a therapeutically effective amount of an inhibitor of the histone methyltransferase, SETD2.
    Type: Application
    Filed: August 14, 2018
    Publication date: January 7, 2021
    Inventors: Alexandra Rose Grassian, Michael THOMENIUS, Jennifer Anne TOTMAN
  • INHIBITION OF SMARCA2 FOR TREATMENT OF CANCER
    Publication number: 20200069669
    Abstract: The present disclosure provides treatment modalities, e.g., strategies, treatment methods, patient stratification methods, combinations, and compositions that are useful for the treatment of disorders, e.g., proliferative disorders, such as certain cancer. Some aspects of this disclosure provide treatment modalities, methods, strategies, compositions, combinations, and dosage forms for the treatment of cell proliferative disorders, e.g., cancers with decreased activity or function, or loss of function, of SMARCA4 with a SMARCA2 antagonist.
    Type: Application
    Filed: February 28, 2018
    Publication date: March 5, 2020
    Inventors: Alexandra Rose GRASSIAN, Allison DREW