Patents by Inventor Alexandra Sophie DE BOER

Alexandra Sophie DE BOER has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR PURIFYING POLYRIBONUCLEOTIDES
    Publication number: 20250051386
    Abstract: The present disclosure relates to compositions and methods for separating and/or purifying polyribonucleotides. The polyribonucleotide may be separated from a mixture of polyribonucleotides with an oligonucleotide that hybridizes to a target region of the polyribonucleotide.
    Type: Application
    Filed: December 22, 2022
    Publication date: February 13, 2025
    Inventors: Alexandra Sophie DE BOER, Nicholas McCartney PLUGIS, Catherine CIFUENTES-ROJAS, Ki Young PAEK, Elissa Magdalene HOBERT, Joshua Nathan FARB, Vadim DUDKIN
  • METHODS FOR ENRICHMENT OF CIRCULAR RNA UNDER DENATURING CONDITIONS
    Publication number: 20240401024
    Abstract: The present disclosure is directed to methods for the enrichment of circular polyribonucleotides (circRNA), e.g., from population of polyribonucleotides containing circRNA and linear polyribonucleotides (linRNA), where the enrichment is performed under denaturing conditions. Also disclosed are compositions including a population of polyribonucleotides containing circRNA and linRNA in a solution under denaturing conditions. Further within the scope of the present disclosure are compositions containing an enriched population of circRNA, such as a composition that was produced by exposing the composition to one or more denaturing conditions.
    Type: Application
    Filed: December 16, 2022
    Publication date: December 5, 2024
    Inventors: Alexandra Sophie DE BOER, Nicholas McCartney PLUGIS, Anthony Joseph CURA, Joshua Nathan FARB, Dineshkumar MANVAR, Tushar Kanti MISRA, Jennifer A. NELSON
  • METHODS OF ENRICHING FOR CIRCULAR POLYRIBONUCLEOTIDES
    Publication number: 20240240218
    Abstract: The methods of the disclosure can be used to enrich a population of circular polyribonucleotides in a mixture of linear polyribonucleotides and circular polyribonucleotides.
    Type: Application
    Filed: May 18, 2022
    Publication date: July 18, 2024
    Inventors: Alexandra Sophie De Boer, Elissa Magdalene HOBERT, Joseph Arthur DEPETER
  • COMPOSITIONS COMPRISING CIRCULAR POLYRIBONUCLEOTIDES AND USES THEREOF
    Publication number: 20240122959
    Abstract: This invention relates generally to pharmaceutical compositions and preparations of circular polyribonucleotides and uses thereof.
    Type: Application
    Filed: December 18, 2023
    Publication date: April 18, 2024
    Inventors: Avak KAHVEJIAN, Alexandra Sophie De Boer, Nicholas McCartney Plugis, Erica Gabrielle Weinstein, Sebastian Trousil, Morag Helen Stewart, Ki Young Paek, Catherine Cifuentes-Rojas
  • IMMUNOGENIC COMPOSITIONS AND USES THEREOF
    Publication number: 20240009298
    Abstract: This disclosure provides compositions, pharmaceutical preparations, and uses of polyribonucleotides encoding one or more immunogenic polypeptides. In particular, this disclosure features circular polyribonucleotide encoding one or more immunogenic polypeptides.
    Type: Application
    Filed: September 3, 2021
    Publication date: January 11, 2024
    Inventors: Avak KAHVEJIAN, Alexandra Sophie DE BOER, Yann Paul Guy Régis ECHELARD, Nicholas McCartney PLUGIS, Erica Gabrielle WEINSTEIN, Jennifer A. NELSON
  • ADIPOGENIC CELL COMPOSITIONS AND METHODS
    Publication number: 20240009249
    Abstract: Disclosed herein are compositions comprising adipogenic cells that are useful for the treatment, prevention, or amelioration of diseases or disorders.
    Type: Application
    Filed: November 24, 2021
    Publication date: January 11, 2024
    Inventors: Alexandra Sophie DE BOER, Le Phuan Lizzie NGO, Avak KAHVEJIAN, Jordan LEWANDOWSKI
  • Compositions comprising circular polyribonucleotides and uses thereof
    Patent number: 11844759
    Abstract: This invention relates generally to pharmaceutical compositions and preparations of circular polyribonucleotides and uses thereof.
    Type: Grant
    Filed: November 16, 2022
    Date of Patent: December 19, 2023
    Assignee: Flagship Pioneering Innovations VI, LLC
    Inventors: Avak Kahvejian, Alexandra Sophie De Boer, Nicholas McCartney Plugis, Erica Gabrielle Weinstein, Sebastian Trousil, Morag Helen Stewart, Ki Young Paek, Catherine Cifuentes-Rojas
  • COMPOSITIONS COMPRISING LINEAR POLYRIBONUCLEOTIDES FOR PROTEIN MODULATION AND USES THEREOF
    Publication number: 20230340451
    Abstract: This invention relates to compositions comprising linear polyribonucleotides and uses thereof.
    Type: Application
    Filed: January 29, 2021
    Publication date: October 26, 2023
    Inventors: Avak KAHVEJIAN, Alexandra Sophie DE BOER
  • COMPOSITIONS AND METHODS FOR PRODUCING CIRCULAR POLYRIBONUCLEOTIDES
    Publication number: 20230212629
    Abstract: The present disclosure relates, generally, to compositions and methods for producing, purifying, and using circular RNA.
    Type: Application
    Filed: February 13, 2023
    Publication date: July 6, 2023
    Inventors: Vadim DUDKIN, Ki Young PAEK, Alexandra Sophie DE BOER, Jennifer A. NELSON
  • COMPOSITIONS COMPRISING CIRCULAR POLYRIBONUCLEOTIDES AND USES THEREOF
    Publication number: 20230201241
    Abstract: This invention relates generally to pharmaceutical compositions and preparations of circular polyribonucleotides and uses thereof.
    Type: Application
    Filed: November 16, 2022
    Publication date: June 29, 2023
    Inventors: Avak Kahvejian, Alexandra Sophie De Boer, Nicholas McCartney Plugis, Erica Gabrielle Weinstein, Sebastian Trousil, Morag Helen Stewart, Ki Young Paek, Catherine Cifuentes-Rojas
  • COMPOSITIONS AND METHODS FOR PRODUCING HUMAN POLYCLONAL ANTIBODIES
    Publication number: 20230203192
    Abstract: The disclosure provides compositions and methods for generating polyclonal antibodies, for example, using circular polyribonucleotides and non-human animals having humanized immune systems.
    Type: Application
    Filed: May 20, 2021
    Publication date: June 29, 2023
    Inventors: Alexandra Sophie DE BOER, Avak KAHVEJIAN, Frances Marion Nicole ANASTASSACOS, Jennifer A. NELSON, Nicholas McCartney PLUGIS, Roger Joseph HAJJAR, Yann Paul Guy Régis ECHELARD
  • IMMUNOGENIC COMPOSITIONS AND USES THEREOF
    Publication number: 20230193311
    Abstract: This disclosure provides compositions, pharmaceutical preparations, and uses of polyribonucleotides encoding one or more immunogenic polypeptides. In particular, this disclosure features circular polyribonucleotide encoding one or more immunogenic polypeptides.
    Type: Application
    Filed: May 20, 2021
    Publication date: June 22, 2023
    Inventors: Avak KAHVEJIAN, Alexandra Sophie DE BOER, Yann Paul Guy Régis ECHELARD, Nicholas McCartney PLUGIS, Erica Gabrielle WEINSTEIN, Jennifer A. NELSON
  • CORONAVIRUS ANTIGEN COMPOSITIONS AND THEIR USES
    Publication number: 20230181722
    Abstract: The disclosure provides compositions and methods comprising circular polyribonucleotides comprising a sequence encoding a coronavirus antigen, and compositions and methods comprising linear polyribonucleotides comprising a sequence encoding a coronavirus antigen. Compositions and methods are provided that are related to generating polyclonal antibodies, for example, using the disclosed circular polyribonucleotides or the disclosed linear polyribonucleotides.
    Type: Application
    Filed: May 20, 2021
    Publication date: June 15, 2023
    Inventors: Avak KAHVEJIAN, Alexandra Sophie DE BOER, Yann Paul Guy Régis ECHELARD, Nicholas McCartney PLUGIS, Roger Joseph HAJJAR, Michael Donato MELFI, Jennifer A. NELSON
  • COMPOSITIONS FOR TRANSLATION AND METHODS OF USE THEREOF
    Publication number: 20230181620
    Abstract: This invention relates generally to pharmaceutical compositions and preparations of polyribonucleotides and circular polyribonucleotides and uses thereof.
    Type: Application
    Filed: January 29, 2021
    Publication date: June 15, 2023
    Inventors: Avak KAHVEJIAN, Alexandra Sophie DE BOER, Nicholas McCartney PLUGIS, Ki Young PAEK
  • DELIVERY OF COMPOSITIONS COMPRISING CIRCULAR POLYRIBONUCLEOTIDES
    Publication number: 20230104113
    Abstract: This invention relates generally to delivery of circular polyribonucleotides and compositions thereof.
    Type: Application
    Filed: January 29, 2021
    Publication date: April 6, 2023
    Inventors: Avak KAHVEJIAN, Nicholas McCartney PLUGIS, Alexandra Sophie DE BOER, Erica Gabrielle WEINSTEIN, Catherine CIFUENTES-ROJAS
  • COMPOSITIONS COMPRISING MODIFIED CIRCULAR POLYRIBONUCLEOTIDES AND USES THEREOF
    Publication number: 20230072532
    Abstract: This invention relates generally to pharmaceutical compositions and preparations of modified circular polyribonucleotides and uses thereof.
    Type: Application
    Filed: March 25, 2020
    Publication date: March 9, 2023
    Inventors: Avak KAHVEJIAN, Nicholas McCartney PLUGIS, Alexandra Sophie DE BOER, Catherine CIFUENTES-ROJAS, Ki Young PAEK
  • COMPOSITIONS COMPRISING CIRCULAR POLYRIBONUCLEOTIDES AND USES THEREOF
    Publication number: 20230070937
    Abstract: This invention relates generally to pharmaceutical compositions and preparations of circular polyribonucleotides and uses thereof.
    Type: Application
    Filed: August 30, 2022
    Publication date: March 9, 2023
    Inventors: Avak Kahvejian, Alexandra Sophie De Boer, Nicholas McCartney Plugis, Erica Gabrielle Weinstein, Sebastian Trousil, Morag Helen Stewart, Ki Young Paek, Catherine Cifuentes-Rojas
  • METHODS OF DOSING CIRCULAR POLYRIBONUCLEOTIDES
    Publication number: 20230061936
    Abstract: This invention relates generally to methods of dosing pharmaceutical compositions and preparations of circular polyribonucleotides thereof.
    Type: Application
    Filed: October 31, 2022
    Publication date: March 2, 2023
    Inventors: Avak KAHVEJIAN, Alexandra Sophie DE BOER, Nicholas McCartney PLUGIS
  • Compositions comprising circular polyribonucleotides and uses thereof
    Patent number: 11458156
    Abstract: This invention relates generally to pharmaceutical compositions and preparations of circular polyribonucleotides and uses thereof.
    Type: Grant
    Filed: September 22, 2021
    Date of Patent: October 4, 2022
    Assignee: Flagship Pioneering Innovations VI, LLC
    Inventors: Alexandra Sophie De Boer, Avak Kahvejian, Nicholas McCartney Plugis, Erica Gabrielle Weinstein, Sebastian Trousil, Morag Helen Stewart, Ki Young Paek, Catherine Cifuentes-Rojas
  • COMPOSITIONS COMPRISING CIRCULAR POLYRIBONUCLEOTIDES FOR PROTEIN MODULATION AND USES THEREOF
    Publication number: 20220305128
    Abstract: This invention relates to compositions comprising circular polyribonucleotides and uses thereof.
    Type: Application
    Filed: June 19, 2020
    Publication date: September 29, 2022
    Inventors: Avak KAHVEJIAN, Nicholas McCartney PLUGIS, Alexandra Sophie DE BOER, Catherine CIFUENTES-ROJAS, Ki Young PAEK