Patents by Inventor Alexandre Bolotine

Alexandre Bolotine has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for monitoring multiple gene expression
    Patent number: 8362221
    Abstract: The present invention relates to methods for monitoring differential expression of a plurality of genes in a first Bacillus cell relative to expression of the same genes in one or more second Bacillus cells using microarrays containing Bacillus genomic sequenced tags. The present invention also relates to computer readable media and computer-based systems. The present invention further relates to substrates containing an array of Bacillus licheniformis or Bacillus clausii GSTs.
    Type: Grant
    Filed: March 15, 2012
    Date of Patent: January 29, 2013
    Assignees: Novozymes, Inc., Novozymes A/S
    Inventors: Randy M. Berka, Ib Groth Clausen, Alexandre Bolotine, Alexei Sorokine, Alla Lapidus
  • Methods For Monitoring Multiple Gene Expression
    Publication number: 20120214221
    Abstract: The present invention relates to methods for monitoring differential expression of a plurality of genes in a first Bacillus cell relative to expression of the same genes in one or more second Bacillus cells using microarrays containing Bacillus genomic sequenced tags. The present invention also relates to computer readable media and computer-based systems. The present invention further relates to substrates containing an array of Bacillus licheniformis or Bacillus clausii GSTs.
    Type: Application
    Filed: April 30, 2012
    Publication date: August 23, 2012
    Applicants: Novozymes, Inc., Novozymes A/S
    Inventors: Randy M. Berka, Ib Groth Clausen, Alexandre Bolotine, Alexei Sorokine, Alla Lapidus
  • Methods for monitoring multiple gene expression
    Publication number: 20120171749
    Abstract: The present invention relates to methods for monitoring differential expression of a plurality of genes in a first Bacillus cell relative to expression of the same genes in one or more second Bacillus cells using microarrays containing Bacillus genomic sequenced tags. The present invention also relates to computer readable media and computer-based systems. The present invention further relates to substrates containing an array of Bacillus licheniformis or Bacillus clausii GSTs.
    Type: Application
    Filed: March 15, 2012
    Publication date: July 5, 2012
    Applicants: Novozymes, Inc., Novozymes A/S
    Inventors: Alexandre Bolotine, Alexei Sorokine, Alla Lapidus, Randy M. Berka, Ib Groth Clausen
  • Methods for monitoring multiple gene expression
    Patent number: 8168773
    Abstract: The present invention relates to methods for monitoring differential expression of a plurality of genes in a first Bacillus cell relative to expression of the same genes in one or more second Bacillus cells using microarrays containing Bacillus genomic sequenced tags. The present invention also relates to computer readable media and computer-based systems. The present invention further relates to substrates containing an array of Bacillus licheniformis or Bacillus clausii GSTs.
    Type: Grant
    Filed: April 1, 2010
    Date of Patent: May 1, 2012
    Assignees: Novozymes, Inc., Novozymes A/S
    Inventors: Randy M. Berka, Ib Groth Clausen, Alexandre Bolotine, Alexei Sorokine, Alla Lapidus
  • Methods for monitoring multiple gene expression
    Publication number: 20100267584
    Abstract: The present invention relates to methods for monitoring differential expression of a plurality of genes in a first Bacillus cell relative to expression of the same genes in one or more second Bacillus cells using microarrays containing Bacillus genomic sequenced tags. The present invention also relates to computer readable media and computer-based systems. The present invention further relates to substrates containing an array of Bacillus licheniformis or Bacillus clausii GSTs.
    Type: Application
    Filed: April 1, 2010
    Publication date: October 21, 2010
    Applicants: Novozymes A/S, Novozymes, Inc.
    Inventors: Alexandre Bolotine, Alexei Sorokine, Alla Lapidus, Randy M. Berka, Ib Groth Clausen
  • Methods for monitoring multiple gene expression
    Patent number: 7691574
    Abstract: The present invention relates to methods for monitoring differential expression of a plurality of genes in a first Bacillus cell relative to expression of the same genes in one or more second Bacillus cells using microarrays containing Bacillus genomic sequenced tags. The present invention also relates to computer readable media and computer-based systems. The present invention further relates to substrates containing an array of Bacillus licheniformis or Bacillus clausii GSTs.
    Type: Grant
    Filed: August 12, 2005
    Date of Patent: April 6, 2010
    Assignees: Novozymes, Inc., Novozymes A/S
    Inventors: Randy M. Berka, Ib Groth Clausen, Alexandre Bolotine, Alexei Sorokine, Alla Lapidus
  • Methods for monitoring multiple gene expression
    Publication number: 20070015168
    Abstract: The present invention relates to methods for monitoring differential expression of a plurality of genes in a first Bacillus cell relative to expression of the same genes in one or more second Bacillus cells using microarrays containing Bacillus genomic sequenced tags. The present invention also relates to computer readable media and computer-based systems. The present invention further relates to substrates containing an array of Bacillus licheniformis or Bacillus clausii GSTs.
    Type: Application
    Filed: August 12, 2005
    Publication date: January 18, 2007
    Applicants: Novozymes A/S, Novozymes, Inc.
    Inventors: Alexandre Bolotine, Alexei Sorokine, Alla Lapidus, Randy Berka, Ib Clausen
  • Gram-positive bacteria deprived of HtrA protease activity and their uses
    Publication number: 20060228377
    Abstract: The invention concerns bacteria strains, obtained from gram-positive bacteria whereof the genome size is not more than 3.2 Mb, and wherein the HtrA surface protease is inactive. Said strains are useful for expressing exported proteins of interest.
    Type: Application
    Filed: September 30, 2005
    Publication date: October 12, 2006
    Inventors: Isabelle Poquet, Alexandra Gruss, Alexandre Bolotine, Alexei Sorokine
  • Methods for monitoring multiple gene expression
    Patent number: 7018794
    Abstract: The present invention relates to methods for monitoring differential expression of a plurality of genes in a first Bacillus cell relative to expression of the same genes in one or more second Bacillus cells using microarrays containing Bacillus genomic sequenced tags. The present invention also relates to computer readable media and computer-based systems. The present invention further relates to substrates containing an array of Bacillus licheniformis or Bacillus clausii GSTs.
    Type: Grant
    Filed: October 5, 2001
    Date of Patent: March 28, 2006
    Assignee: Novozymes, Inc.
    Inventors: Randy M. Berka, Ib Groth Clausen, Alexandre Bolotine, Alexei Sorokine, Alla Lapidus
  • Gram positive bacteria deprived of HtrA protease activity and their uses
    Patent number: 6994997
    Abstract: The invention concerns bacteria strains, obtained from gram-positive bacteria whereof the genome size is not more than 3.2 Mb, and wherein the HtrA surface protease is inactive. Said strains are useful for expressing exported proteins of interest.
    Type: Grant
    Filed: December 23, 1999
    Date of Patent: February 7, 2006
    Assignee: Institut National de la Recherche Agronomique
    Inventors: Isabelle Poquet, Alexandra Gruss, Alexandre Bolotine, Alexei Sorokine