Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of HPK1, and the treatment of HPK1-mediated disorders.

Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of HPK1, and the treatment of HPK1-mediated disorders.

Abstract: The present disclosure relates to inhibitors of NLRP3 useful in the treatment of diseases and disorders inhibited by said protein and having the Formula (I):

Abstract: The present disclosure relates to compounds of Formula (I): or a pharmaceutically acceptable salt, solvate, clathrate, hydrate, stereoisomer, tautomer, isotopic derivative, prodrug or polymorph thereof. Further provided are pharmaceutical compositions comprising the same, methods of preparation, and methods of use and treatment, e.g., as inhibitors of NLRP3 useful in the treatment of diseases and disorders inhibited by said protein.

Abstract: The present disclosure relates to inhibitors of NLRP3 useful in the treatment of diseases and disorders inhibited by said protein and having the Formula (I):

Abstract: The present disclosure relates to inhibitors of NLRP3 useful in the treatment of diseases and disorders inhibited by said protein and having the Formula (I):

Abstract: The present invention provides compounds of formula I, compositions thereof, and methods of using the same for the inhibition of HPK1, and the treatment of HPK1-mediated disorders.

Abstract: The present disclosure relates to inhibitors of NLRP3 useful in the treatment of diseases and disorders inhibited by said protein and having the Formula (I):

Abstract: A snow plow blade assembly has sidewalls rotating when abutting an obstacle and returning to the default position when not abutting the obstacle anymore. The snow plow blade assembly comprises a central section comprising a pivot axis; sidewall assemblies pivotably mounted to the central section; and suspension assemblies mounted to the central section. The suspension assemblies connect the central section and the sidewall assembly distant from the pivot axis. The suspension assemblies may comprise a hydraulic jack controllable between an extended position and a compact position, wherein the suspension assemblies allows the sidewall assemblies to pivot up to a first angle when contacting an obstacle and to pivot to a second angle greater than the first angle by changing the position of the hydraulic jack.

Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of HPK1, and the treatment of HPK1-mediated disorders.

Abstract: The present disclosure relates to inhibitors of NLRP3 useful in the treatment of diseases and disorders inhibited by said protein and having the Formula (I):

Abstract: Described herein are compounds that are useful in treating a USP7-mediated disorder. In some embodiments, the USP7-mediated disorder is cancer.

Abstract: The present disclosure relates to inhibitors of NLRP3 useful in the treatment of diseases and disorders inhibited by said protein and having the Formula (I):

Abstract: Provided are novel compounds of Formula (I): and pharmaceutically acceptable salts thereof, which are useful for treating a variety of diseases, disorders or conditions, associated with methyl modifying enzymes. Also provided are pharmaceutical compositions comprising the novel compounds of Formula (I), pharmaceutically acceptable salts thereof, and methods for their use in treating one or more diseases, disorders or conditions, associated with methyl modifying enzymes.

Abstract: Provided are novel compounds of Formula (I): Formula (I); and pharmaceutically acceptable salts thereof, which are useful for treating a variety of diseases, disorders or conditions, associated with methyl modifying enzymes. Also provided are pharmaceutical compositions comprising the novel compounds of Formula (I), pharmaceutically acceptable salts thereof, and methods for their use in treating one or more diseases, disorders or conditions, associated with methyl modifying enzymes.

Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of HPK1, and the treatment of HPK1-mediated disorders.

Abstract: This disclosure relates to LPA antagonists of Formula (I): including pharmaceutically acceptable salts and solvates thereof, and pharmaceutical compositions including the same.

Abstract: The present disclosure relates to inhibitors of NLRP3 useful in the treatment of diseases and disorders inhibited by said protein and having the Formula (I):

Abstract: Disclosed is an apparatus and method for operating a gliding parachute/kite. The gliding parachute/kite has a wing with a flexible material, and a set of suspension lines adapted for coupling a load to the wing, such that the coupling is configurable in any one of a plurality of possible states based on relative lengths of the suspension lines. In some implementations, the possible states include a first state enabling gliding in a first direction, and a second state enabling gliding in a second direction that is opposite to the first direction. Reversing direction is possible with the first and second states. Additionally, or alternatively, the possible states include a spinning state enabling spinning of the gliding parachute/kite. Adjusting a rate of decent is possible with the spinning. Reversing direction and/or spinning operations can be used to improve control of trajectory.

Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of HPK1, and the treatment of HPK1-mediated disorders.