Abstract: The present disclosure relates to inhibitors of NLRP3 useful in the treatment of diseases and disorders inhibited by said protein and having the Formula (I):

Abstract: Provided are novel compounds of Formula (I): and pharmaceutically acceptable salts thereof, which are useful for treating a variety of diseases, disorders or conditions, associated with methyl modifying enzymes. Also provided are pharmaceutical compositions comprising the novel compounds of Formula (I), pharmaceutically acceptable salts thereof, and methods for their use in treating one or more diseases, disorders or conditions, associated with methyl modifying enzymes.

Abstract: The present disclosure relates to compounds of Formula (I), (II), and (III): and pharmaceutically acceptable salts, tautomers, and/or isotopically labeled derivatives thereof, wherein X1, X2, RA, y, R3, R4, R5, R6, R7, R6A, R6B, a and b are as defined herein, and Ring A2 is a monocyclic pyrazolyl ring, and methods of preparation of same. The present disclosure further relates to pharmaceutical compositions and methods of treatment, e.g., of cGAS-related diseases and disorders, comprising compounds of Formula (I) or (III). Compounds of Formula (II) may be useful as tool compounds in binding, functional, and/or cellular assays.

Abstract: The present disclosure relates to inhibitors of NLRP3 useful in the treatment of diseases and disorders inhibited by said protein and having the Formula (I):

Abstract: The present disclosure relates to compounds of Formula (I-B): and pharmaceutically acceptable salts and tautomers thereof, wherein Ring A, Ring B, R1, R2a, R2b, R3, R4, m, n, and p are described herein, and methods of preparation, methods of treatment and prevention, and pharmaceutical compositions comprising same. The present disclosure further relates to the use of the compounds of Formula (I-B), and pharmaceutically acceptable salts and tautomers thereof, in the treatment or prevention of NLRP3-related diseases and disorders.

Abstract: The present disclosure relates to compounds of Formula (I-A): and pharmaceutically acceptable salts and tautomers thereof, wherein Ring A, Ring B, R1, R2a, R2b, R3, m, n, and p are described herein, and methods of preparation, methods of treatment and prevention, and pharmaceutical compositions comprising same. The present disclosure further relates to the use of the compounds of Formula (I-A), and pharmaceutically acceptable salts and tautomers thereof, in the treatment and prevention of NLRP3-related diseases and disorders.

Abstract: A trigger assembly for attaching a snow plow blade to a vehicle is described. The trigger assembly consists in a combination of a nesting arm and a nested arm rotatable around one another, wherein the arms are furthermore coupled through a biasing means. The trigger assembly is adapted for reacting when the ground-contacting edge of the snow plow blade hitting an obstacle in the nested arm rotating out of the nesting arm and the biasing means being extended.

Abstract: An attachment assembly for attaching a snow plow blade to a vehicle includes a pair of interface brackets, a pair of articulated intermediate structures mounted to the interface brackets, a transversal member joining the intermediate structures, and a trigger assembly. The trigger assembly includes a static member with a pivoting attachment point for attachment to the snow plow blade and top and bottom attachment points for releasable attachment to the intermediate structure, a pin assembly, and a biasing means attached to the pin assembly and to the static member. The trigger assembly is biased toward a default position in which the pin member and the static member are at their closest. When applying a torque on the snow plow blade above a trigger threshold, the snow plow blade rotates from the default position to a triggered position.

Abstract: The present disclosure relates to inhibitors of NLRP3 useful in the treatment of diseases and disorders inhibited by said protein and having the Formula (I):

Abstract: The present disclosure relates to inhibitors of NLRP3 useful in the treatment of diseases and disorders inhibited by said protein and having the Formula (I):

Abstract: An assembly comprising an excavation bucket and a bracket to mount the excavation bucket thereto, wherein the assembly allows to selectively mount the excavation bucket to an articulated arm with the receptacle of the excavation bucket facing frontward or facing rearward.

Abstract: The present disclosure relates to inhibitors of NLRP3 useful in the treatment of diseases and disorders inhibited by said protein and having the Formula (I):

Abstract: The present disclosure relates to compounds of Formula (I): or a pharmaceutically acceptable salt, solvate, clathrate, hydrate, stereoisomer, tautomer, isotopic derivative, prodrug or polymorph thereof. Further provided are pharmaceutical compositions comprising the same, methods of preparation, and methods of use and treatment, e.g., as inhibitors of NLRP3 useful in the treatment of diseases and disorders inhibited by said protein.

Abstract: The present disclosure relates to inhibitors of NLRP3 useful in the treatment of diseases and disorders inhibited by said protein and having the Formula (I):

Abstract: The present disclosure relates to inhibitors of NLRP3 useful in the treatment of diseases and disorders inhibited by said protein and having the Formula (I):

Abstract: A snow plow blade assembly has sidewalls rotating when abutting an obstacle and returning to the default position when not abutting the obstacle anymore. The snow plow blade assembly comprises a central section comprising a pivot axis; sidewall assemblies pivotably mounted to the central section; and suspension assemblies mounted to the central section. The suspension assemblies connect the central section and the sidewall assembly distant from the pivot axis. The suspension assemblies may comprise a hydraulic jack controllable between an extended position and a compact position, wherein the suspension assemblies allows the sidewall assemblies to pivot up to a first angle when contacting an obstacle and to pivot to a second angle greater than the first angle by changing the position of the hydraulic jack.

Abstract: The present disclosure relates to inhibitors of NLRP3 useful in the treatment of diseases and disorders inhibited by said protein and having the Formula (I):

Abstract: The present disclosure relates to inhibitors of NLRP3 useful in the treatment of diseases and disorders inhibited by said protein and having the Formula (I):

Abstract: The present disclosure relates to inhibitors of NLRP3 useful in the treatment of diseases and disorders inhibited by said protein and having the Formula (I):

Abstract: Provided are novel compounds of Formula (I): and pharmaceutically acceptable salts thereof, which are useful for treating a variety of diseases, disorders or conditions, associated with methyl modifying enzymes. Also provided are pharmaceutical compositions comprising the novel compounds of Formula (I), pharmaceutically acceptable salts thereof, and methods for their use in treating one or more diseases, disorders or conditions, associated with methyl modifying enzymes.