Patents by Inventor Alexandre Charles

Alexandre Charles has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12226439
    Abstract: Provided are delivery immunostimulatory bacteria that have enhanced colonization of tumors, the tumor microenvironment and/or tumor-resident immune cells, and enhanced anti-tumor activity. The immunostimulatory bacteria are modified by deletion of genes encoding the flagella, or by modification of the genes so that functional flagella are not produced, and/or are modified by deletion of pagP or modification of pagP to produce inactive PagP product. As a result, the immunostimulatory bacteria are flagellin? and/or pagP?. The immunostimulatory bacteria optionally have additional genomic modifications so that the bacteria are adenosine or purine auxotrophs. The bacteria optionally are one or more of asd?, purI?, and msbB?.
    Type: Grant
    Filed: September 21, 2022
    Date of Patent: February 18, 2025
    Assignee: Actym Therapeutics, Inc.
    Inventors: Christopher D. Thanos, Laura Hix Glickman, Justin Skoble, Alexandre Charles Michel Iannello
  • Patent number: 12201653
    Abstract: Provided are delivery immunostimulatory bacteria that have enhanced colonization of tumors, the tumor microenvironment and/or tumor-resident immune cells, and enhanced anti-tumor activity. The immunostimulatory bacteria are modified by deletion of genes encoding the flagella, or by modification of the genes so that functional flagella are not produced, and/or are modified by deletion of pagP or modification of pagP to produce inactive PagP product. As a result, the immunostimulatory bacteria are flagellin? and/or pagP?. The immunostimulatory bacteria optionally have additional genomic modifications so that the bacteria are adenosine or purine auxotrophs. The bacteria optionally are one or more of asd?, purI?, and msbB?.
    Type: Grant
    Filed: May 18, 2022
    Date of Patent: January 21, 2025
    Assignee: Actym Therapeutics, Inc.
    Inventors: Christopher D. Thanos, Laura Hix Glickman, Justin Skoble, Alexandre Charles Michel Iannello
  • Publication number: 20240293478
    Abstract: Provided are methods for treating cancer by converting tumor-resident macrophages into a hybrid M1/M2 macrophage phenotype; this phenotype has attributes that are advantageous for cancer therapy. Hybrid markers include (lower than M2, higher than M1): SPP1, CD209, and CD206, and induced markers include MERTK, C1QC, IFNa, IFNb, CXCL10, 4-1BBL, and MYC. The methods include administering a therapeutic that effects the phenotypic conversion. Therapeutics, such as delivery vehicles, including immunostimulatory bacteria with genome modifications, are designed so that they do not induce or result in a sufficient TLR2, TLR4, TLR5 response to inhibit type I IFN. The therapeutics also encode a payload that encodes immunostimulatory proteins, such as a cytokine and a modified cytosolic DNA/RNA sensor that constitutively induces type I IFN, such as a modified STING protein.
    Type: Application
    Filed: May 9, 2024
    Publication date: September 5, 2024
    Inventors: Akshata Udyavar, Laura Hix Glickman, Chingnam Cheung, Alexandre Charles Michel Iannello, Bret Nicholas Peterson, Nicholas Boyce Woodall, Christopher D. Thanos
  • Publication number: 20240221315
    Abstract: One variation of a method for modeling a human body includes: driving a sensor block along a path above a platform occupied by a user and recording a sequence of depth images and color images, via the sensor block, at each capture position in a sequence of capture positions along the path; compiling the set of depth images into a low-density 3D model of the user and a high-density 3D model of the user; extracting a set of color patches, from the sequence of color images, corresponding to discrete regions on a surface of the low-density 3D model of the user; projecting the set of color patches onto the surface of the low-density 3D model to generate a 3D color model of the user; and extracting a value of a dimension, projected from the low-density 3D color model onto the high-density 3D model, from the high-density 3D model.
    Type: Application
    Filed: January 11, 2024
    Publication date: July 4, 2024
    Inventor: Alexandre Charles M. Wayenberg
  • Patent number: 12024709
    Abstract: Provided are delivery immunostimulatory bacteria that have enhanced colonization of tumors, the tumor microenvironment and/or tumor-resident immune cells, and enhanced anti-tumor activity. The immunostimulatory bacteria are modified by deletion of genes encoding the flagella or by modification of the genes so that functional flagella are not produced, and/or are modified by deletion of pagP or modification of pagP to produce inactive PagP product. As a result, the immunostimulatory bacteria are flagellin? and/or pagP?. The immunostimulatory bacteria optionally have additional genomic modifications so that the bacteria are adenosine and/or purine auxotrophs. The bacteria optionally are one or more of asd?, purI? and msbB?.
    Type: Grant
    Filed: March 19, 2020
    Date of Patent: July 2, 2024
    Assignee: Actym Therapeutics, Inc.
    Inventors: Christopher D. Thanos, Laura Hix Glickman, Justin Skoble, Alexandre Charles Michel Iannello, Haixing Kehoe
  • Patent number: 11962616
    Abstract: A method and associated circuits protect data stored in a secure data circuit of a telecommunication device equipped with a near-field communication (NFC) router, a microcontroller, and the secure data circuit. In the method, each message received with the NFC router is parsed to retrieve a communication pipe identifier and an instruction code. The communication pipe identifier and the instruction code are compared to corresponding information in a filter table. Instruction codes of particular messages that attempt to modify a communication pipe by reassigning one end of the communication pipe from the port of the NFC router to a different circuit are acted upon. These messages are blocked from reaching the secure data circuit when the instruction code is not authorized in the filter table, and these messages are permitted when the instruction code is authorized in the filter table.
    Type: Grant
    Filed: January 11, 2021
    Date of Patent: April 16, 2024
    Assignees: PROTON WORLD INTERNATIONAL N.V., STMICROELECTRONICS (ROUSSET) SAS
    Inventors: Olivier Van Nieuwenhuyze, Thierry Huque, Alexandre Charles
  • Publication number: 20240114324
    Abstract: A device, including a main element and a set of at least two auxiliary elements, the main element including a master SWP interface, each auxiliary element including a slave SWP interface connected to the master SWP interface of the NFC element through a controllably switchable SWP link and management circuit configured to control the SWP link switching for selectively activating at once only one slave SWP interface on the SWP link.
    Type: Application
    Filed: November 30, 2023
    Publication date: April 4, 2024
    Inventors: Thierry Meziache, Pierre Rizzo, Alexandre Charles, Juergen Boehler
  • Patent number: 11934329
    Abstract: Data exchanges between an ultra-wide band communication module and a secure element are controlled such that the data exchanges pass through a near-field communication router. The near-field communication router controls routing of the data exchanges so that the data exchanges do not pass through a host circuit that is also coupled to the near-field communication router.
    Type: Grant
    Filed: January 20, 2020
    Date of Patent: March 19, 2024
    Assignee: STMicroelectronics (Rousset) SAS
    Inventors: Alexandre Tramoni, Alexandre Charles
  • Patent number: 11908078
    Abstract: One variation of a method for modeling a human body includes: driving a sensor block along a path above a platform occupied by a user and recording a sequence of depth images and color images, via the sensor block, at each capture position in a sequence of capture positions along the path; compiling the set of depth images into a low-density 3D model of the user and a high-density 3D model of the user; extracting a set of color patches, from the sequence of color images, corresponding to discrete regions on a surface of the low-density 3D model of the user; projecting the set of color patches onto the surface of the low-density 3D model to generate a 3D color model of the user; and extracting a value of a dimension, projected from the low-density 3D color model onto the high-density 3D model, from the high-density 3D model.
    Type: Grant
    Filed: December 23, 2021
    Date of Patent: February 20, 2024
    Assignee: Shape Labs Inc.
    Inventor: Alexandre Charles M. Wayenberg
  • Patent number: 11889397
    Abstract: A device, including a main element and a set of at least two auxiliary elements, said main element including a master SWP interface, each auxiliary element including a slave SWP interface connected to said master SWP interface of said NFC element through a controllably switchable SWP link and management means configured to control said SWP link switching for selectively activating at once only one slave SWP interface on said SWP link.
    Type: Grant
    Filed: January 27, 2022
    Date of Patent: January 30, 2024
    Assignees: STMicroelectronics (Rousset) SAS, STMICROELECTRONICS GMBH
    Inventors: Thierry Meziache, Pierre Rizzo, Alexandre Charles, Juergen Boehler
  • Patent number: 11779612
    Abstract: Provided are delivery immunostimulatory bacteria that have enhanced colonization of tumors, the tumor microenvironment and/or tumor-resident immune cells, and enhanced anti-tumor activity. The immunostimulatory bacteria are modified by deletion of genes encoding the flagella or modification of the genes so that functional flagella are not produced, and/or are modified by deletion of pagP or modification of pagP to produce inactive PagP product. As a result, the immunostimulatory bacteria are flagellin? and/or pagP?. The immunostimulatory bacteria optionally have additional genomic modifications so that the bacteria are adenosine or purine auxotrophs. The bacteria optionally are one or more of asd?, purI? and msbB?.
    Type: Grant
    Filed: July 23, 2019
    Date of Patent: October 10, 2023
    Assignee: ACTYM THERAPEUTICS, INC.
    Inventors: Christopher D. Thanos, Laura Hix Glickman, Justin Skoble, Alexandre Charles Michel Iannello
  • Publication number: 20230186294
    Abstract: The present description concerns a method of implementation of an NFC transaction between a mobile terminal and a distant module. The terminal includes a processor hosting an application establishing the NFC transaction, a near-field communication module, and a secure element distinct from the processor. The method includes at least the following successive steps: (a) the near-field communication module ciphers first data sent by the distant module by using a first key supplied by the secure element and (b) the first application deciphers the first data by using a second key supplied by the secure elements.
    Type: Application
    Filed: November 22, 2022
    Publication date: June 15, 2023
    Inventors: Olivier Van Nieuwenhuyze, Alexandre Charles
  • Publication number: 20230186278
    Abstract: In an embodiment a method for implementing a NFC transaction between a mobile terminal and a distant module is disclosed. The terminal includes a processor hosting an application configured to establish the NFC transaction and an interface software configured to execute instructions of the application, a near-field communication module and a secure element distinct from the processor.
    Type: Application
    Filed: December 9, 2022
    Publication date: June 15, 2023
    Inventors: Olivier Van Nieuwenhuyze, Alexandre Charles, Alexandra Ducati Manas
  • Publication number: 20230186295
    Abstract: The present description concerns a method of implementation of an NFC transaction between a mobile terminal and a distant module. The terminal includes a processor hosting an application establishing the NFC transaction, a near-field communication module, and a secure element distinct from the processor. The method includes at least the following successive steps: (a) the near-field communication module sends, to the first application, first data sent by the distant module and ciphered by the secure element; and (b) the first application asks the secure element to decipher the first data.
    Type: Application
    Filed: November 22, 2022
    Publication date: June 15, 2023
    Inventors: Olivier Van Nieuwenhuyze, Alexandre Charles
  • Publication number: 20230189002
    Abstract: In an embodiment a method for implementing a NFC transaction between a mobile terminal and a distant module is disclosed. The terminal includes a processor hosting an application configured to establish the NFC transaction, a near-field communication module, and a secure element distinct from the processor. The method includes storing, by the near-field communication module in the secure element, first data from the distant module, sending, by the near-field communication module, second data to the application notifying it that the first data have been stored in the secure element and requesting, by the application, the first data from the secure element.
    Type: Application
    Filed: December 13, 2022
    Publication date: June 15, 2023
    Inventors: Olivier Van Nieuwenhuyze, Alexandre Charles
  • Patent number: 11652512
    Abstract: In an embodiment, an NFC controller of an NFC device is configured to transmit, after the detection, by the NFC controller, of an NFC reader in relation with a first NFC transaction and prior to receiving an application selection command from the NFC reader, an application selection message to a transaction handling element of the NFC device.
    Type: Grant
    Filed: November 28, 2019
    Date of Patent: May 16, 2023
    Assignees: STMicroelectronics (Rousset) SAS, Proton World International N.V.
    Inventors: Olivier Van Nieuwenhuyze, Alexandre Charles
  • Publication number: 20230072505
    Abstract: Provided are delivery immunostimulatory bacteria that have enhanced colonization of tumors, the tumor microenvironment and/or tumor-resident immune cells, and enhanced anti-tumor activity. The immunostimulatory bacteria are modified by deletion of genes encoding the flagella, or by modification of the genes so that functional flagella are not produced, and/or are modified by deletion of pagP or modification of pagP to produce inactive PagP product. As a result, the immunostimulatory bacteria are flagellin? and/or pagP?. The immunostimulatory bacteria optionally have additional genomic modifications so that the bacteria are adenosine or purine auxotrophs. The bacteria optionally are one or more of asd?, purI?, and msbB?.
    Type: Application
    Filed: September 21, 2022
    Publication date: March 9, 2023
    Inventors: Christopher D. THANOS, Laura Hix GLICKMAN, Justin SKOBLE, Alexandre Charles Michel IANNELLO
  • Publication number: 20220395258
    Abstract: An interstitial fluid removal device including a first needle, a second needle, a fluid injector and an interstitial fluid extractor. The first needle is configured for insertion in a tissue of a multicellular organism to provide a fluid inlet channel. The second needle is configured for insertion in a tissue of a multicellular organism to provide an interstitial fluid outlet channel. The fluid injector is arranged in fluid communication with both a fluid source and the first needle and configured to inject a fluid in the tissue of the multicellular organism. The fluid extractor is arranged in fluid communication with the second needle and configured to extract interstitial fluid from the tissue of the multicellular organism. The fluid injector and the fluid extractor are independently and/or simultaneously operable with respect to each other.
    Type: Application
    Filed: November 19, 2020
    Publication date: December 15, 2022
    Inventors: Alexandre Charles Roger MOTTA, Varsha Sakina THAKOERSING, Richardus Paulus Anton ORANJE
  • Publication number: 20220380720
    Abstract: Provided are attenuated immunostimulatory bacteria with genomes that are modified to, for example, reduce toxicity and improve the anti-tumor activity, such as by increasing accumulation in the tumor microenvironment, particularly in tumor-resident myeloid cells, improving resistance to complement inactivation, reducing immune cell death, promoting adaptive immunity, and enhancing T-cell function. The increase in colonization of phagocytic cells improves the delivery of encoded therapeutic products to the tumor microenvironment and tumors, and permits, among other routes, systemic administration of the immunostimulatory bacteria.
    Type: Application
    Filed: May 13, 2021
    Publication date: December 1, 2022
    Inventors: Laura Hix GLICKMAN, Christopher D. Thanos, Alexandre Charles Michel IANNELLO, Chris RAE, Haixing KEHOE, Bret Nicholas Peterson, Chingnam Cheung
  • Publication number: 20220280577
    Abstract: Provided are delivery immunostimulatory bacteria that have enhanced colonization of tumors, the tumor microenvironment and/or tumor-resident immune cells, and enhanced anti-tumor activity. The immunostimulatory bacteria are modified by deletion of genes encoding the flagella, or by modification of the genes so that functional flagella are not produced, and/or are modified by deletion of pagP or modification of pagP to produce inactive PagP product. As a result, the immunostimulatory bacteria are flagellin? and/or pagP?. The immunostimulatory bacteria optionally have additional genomic modifications so that the bacteria are adenosine or purine auxotrophs. The bacteria optionally are one or more of asd?, purI?, and msbB?.
    Type: Application
    Filed: May 18, 2022
    Publication date: September 8, 2022
    Inventors: Christopher D. THANOS, Laura Hix Glickman, Justin Skoble, Alexandre Charles Michel Iannello