Abstract: An interstitial fluid removal device including a first needle, a second needle, a fluid injector and an interstitial fluid extractor. The first needle is configured for insertion in a tissue of a multicellular organism to provide a fluid inlet channel. The second needle is configured for insertion in a tissue of a multicellular organism to provide an interstitial fluid outlet channel. The fluid injector is arranged in fluid communication with both a fluid source and the first needle and configured to inject a fluid in the tissue of the multicellular organism. The fluid extractor is arranged in fluid communication with the second needle and configured to extract interstitial fluid from the tissue of the multicellular organism. The fluid injector and the fluid extractor are independently and/or simultaneously operable with respect to each other.

Abstract: The present invention relates to the fields of medicine and cancer, more particularly to the field of skin cancer (e.g. melanoma and non-melanoma cancers) and skin cancer treatment. Provided are methods for treating skin cancer using microneedle devices for the removal of an amount of interstitial fluid or tumor interstitial fluid from a skin tumor. Also provided are therapeutic compounds for use in the treatment of skin cancer, wherein the treatment comprises removal of an amount of interstitial fluid or tumor interstitial fluid from a skin tumor.