Abstract: Provided are novel compounds of Formula (I): and pharmaceutically acceptable salts thereof, which are useful for treating a variety of diseases, disorders or conditions, associated with methyl modifying enzymes. Also provided are pharmaceutical compositions comprising the novel compounds of Formula (I), pharmaceutically acceptable salts thereof, and methods for their use in treating one or more diseases, disorders or conditions, associated with methyl modifying enzymes.

Abstract: A vehicle includes: a driver seat connected to a frame of the vehicle and disposed in a cockpit area; a dashboard disposed in front of the driver seat; a cargo bed supported by the frame and having a front wall, left and right walls and a cargo bed supporting surface surrounded in part by the front, left and right walls, the front wall having a movable portion that is movable to selectively cover a pass-through opening that communicates an internal space of the cargo bed to the cockpit area; and an extension receptacle disposed in the cockpit area, the extension receptacle being aligned with (i) the dashboard in a longitudinal direction and (ii) the pass-through opening in a lateral direction, the extension receptacle being configured to receive items therein that are inserted from the cargo bed through the pass-through opening and into the cockpit area of the vehicle.

Abstract: Provided are novel compounds of Formula (I): Formula (I); and pharmaceutically acceptable salts thereof, which are useful for treating a variety of diseases, disorders or conditions, associated with methyl modifying enzymes. Also provided are pharmaceutical compositions comprising the novel compounds of Formula (I), pharmaceutically acceptable salts thereof, and methods for their use in treating one or more diseases, disorders or conditions, associated with methyl modifying enzymes.

Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of HPK1, and the treatment of HPK1-mediated disorders.

Abstract: This disclosure relates to LPA antagonists of Formula (I): including pharmaceutically acceptable salts and solvates thereof, and pharmaceutical compositions including the same.

Abstract: The present disclosure relates to inhibitors of NLRP3 useful in the treatment of diseases and disorders inhibited by said protein and having the Formula (I):

Abstract: Disclosed is an apparatus and method for operating a gliding parachute/kite. The gliding parachute/kite has a wing with a flexible material, and a set of suspension lines adapted for coupling a load to the wing, such that the coupling is configurable in any one of a plurality of possible states based on relative lengths of the suspension lines. In some implementations, the possible states include a first state enabling gliding in a first direction, and a second state enabling gliding in a second direction that is opposite to the first direction. Reversing direction is possible with the first and second states. Additionally, or alternatively, the possible states include a spinning state enabling spinning of the gliding parachute/kite. Adjusting a rate of decent is possible with the spinning. Reversing direction and/or spinning operations can be used to improve control of trajectory.

Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of HPK1, and the treatment of HPK1-mediated disorders.

Abstract: An attachment assembly for attaching a snow plow blade to a vehicle includes a pair of interface brackets, a pair of articulated intermediate structures mounted to the interface brackets, a transversal member joining the intermediate structures, and a trigger assembly. The trigger assembly includes a static member with a pivoting attachment point for attachment to the snow plow blade and top and bottom attachment points for releasable attachment to the intermediate structure, a pin assembly, and a biasing means attached to the pin assembly and to the static member. The trigger assembly is biased toward a default position in which the pin member and the static member are at their closest.

Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of HPK1, and the treatment of HPK1-mediated disorders.

Abstract: The present disclosure relates to inhibitors of NLRP3 useful in the treatment of diseases and disorders inhibited by said protein and having the Formula (I):

Abstract: Disclosed is an apparatus and method for operating a gliding parachute/kite. The gliding parachute/kite has a wing with a flexible material, and a set of suspension lines adapted for coupling a load to the wing, such that the coupling is configurable in any one of a plurality of possible states based on relative lengths of the suspension lines. In some implementations, the possible states include a first state enabling gliding in a first direction, and a second state enabling gliding in a second direction that is opposite to the first direction. Reversing direction is possible with the first and second states. Additionally, or alternatively, the possible states include a spinning state enabling spinning of the gliding parachute/kite. Adjusting a rate of decent is possible with the spinning. Reversing direction and/or spinning operations can be used to improve control of trajectory.

Abstract: Provided are compounds of Formula (I): and pharmaceutically acceptable salts and compostions thereof, which are useful for treating a variety of conditions associated with methyl modifying enzymes.

Abstract: A snow plow blade assembly comprises a main blade, an extension blade extending laterally from the main blade; a slide member and a flat bar. An interface is present between the main blade and the extension blade, with the slide member and the flat bar installed at the interface. The slide member slidably cooperates with the flat bar to control or to minimize a gap between the main blade and the extension blade at the interface.

Abstract: Disclosed is an apparatus and method for operating a gliding parachute/kite. The gliding parachute/kite has a wing with a flexible material, and a set of suspension lines adapted for coupling a load to the wing, such that the coupling is configurable in any one of a plurality of possible states based on relative lengths of the suspension lines. In some implementations, the possible states include a first state enabling gliding in a first direction, and a second state enabling gliding in a second direction that is opposite to the first direction. Reversing direction is possible with the first and second states. Additionally, or alternatively, the possible states include a spinning state enabling spinning of the gliding parachute/kite. Adjusting a rate of decent is possible with the spinning. Reversing direction and/or spinning operations can be used to improve control of trajectory.

Abstract: Disclosed is an apparatus and method for operating a gliding parachute/kite. The gliding parachute/kite has a wing with a flexible material, and a set of suspension lines adapted for coupling a load to the wing, such that the coupling is configurable in any one of a plurality of possible states based on relative lengths of the suspension lines. In some implementations, the possible states include a first state enabling gliding in a first direction, and a second state enabling gliding in a second direction that is opposite to the first direction. Reversing direction is possible with the first and second states. Additionally, or alternatively, the possible states include a spinning state enabling spinning of the gliding parachute/kite. Adjusting a rate of decent is possible with the spinning. Reversing direction and/or spinning operations can be used to improve control of trajectory.

Abstract: Provided are novel compounds of Formula (I): and pharmaceutically acceptable salts thereof, which are useful for treating a variety of diseases, disorders or conditions, associated with methyl modifying enzymes. Also provided are pharmaceutical compositions comprising the novel compounds of Formula (I), pharmaceutically acceptable salts thereof, and methods for their use in treating one or more diseases, disorders or conditions, associated with methyl modifying enzymes.

Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of HPK1, and the treatment of HPK1-mediated disorders.

Abstract: Provided are compounds of Formula (I): and pharmaceutically acceptable salts and compostions thereof, which are useful for treating a variety of conditions associated with methyl modifying enzymes.

Abstract: Provided are novel compounds of Formula (I): Formula (I); and pharmaceutically acceptable salts thereof, which are useful for treating a variety of diseases, disorders or conditions, associated with methyl modifying enzymes. Also provided are pharmaceutical compositions comprising the novel compounds of Formula (I), pharmaceutically acceptable salts thereof, and methods for their use in treating one or more diseases, disorders or conditions, associated with methyl modifying enzymes.