Patents by Inventor Alexandre Debacker

Alexandre Debacker has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • INHIBITORS OF EXPRESSION AND/OR FUNCTION
    Publication number: 20260009036
    Abstract: The present invention relates to inhibitors, and compositions containing inhibitors, and uses of the same in the treatment or prevention of vascular and/or metabolic diseases.
    Type: Application
    Filed: March 20, 2025
    Publication date: January 8, 2026
    Inventors: Graham CRAGGS, Alan Victor WHITMORE, Natalie Wayne PURSELL, Alexander Wolfgang Christian FISCHER, Amy MCCARTHY, James LONGDEN, Ines DE SANTIAGO, Duncan BROWN, Ahmad Ali MORTAZAVI, Viviana MANNELLA, Muthusamy JAYARAMAN, Alexandre DEBACKER, Adrian James MOGG
  • NUCLEIC ACID COMPOUNDS
    Publication number: 20250388897
    Abstract: The present invention provides novel nucleic acid compound suitable for therapeutic use. Additionally, the present invention provides methods of making these compounds, as well as methods of using such compounds for the treatment of various diseases and conditions.
    Type: Application
    Filed: July 27, 2023
    Publication date: December 25, 2025
    Inventors: Amy MCCARTHY, Graham CRAGGS, James LONGDEN, Ines DE SANTIAGO, Duncan BROWN, Ahmad Ali MORTAZAVI, Viviana MANNELLA, Muthusamy JAYARAMAN, Alexandre DEBACKER, Adrian James MOGG
  • NUCLEIC ACID COMPOUNDS
    Publication number: 20250368992
    Abstract: The present invention provides novel nucleic acid compounds suitable for therapeutic use. Additionally, the present invention provides methods of making these compounds, as well as methods of using such compounds for the treatment of various diseases and conditions.
    Type: Application
    Filed: July 27, 2023
    Publication date: December 4, 2025
    Inventors: Amy MCCARTHY, Graham CRAGGS, James LONGDEN, Ines DE SANTIAGO, Duncan BROWN, Ahmad Ali MORTZAAVI, Viviana MANNELLA, Muthusamy JAYARAMAN, Damian ELLE, Alison GALLAFENT, Laura ROCA-ALONSO, Alexandre DEBACKER
  • INHIBITORS OF EXPRESSION AND/OR FUNCTION
    Publication number: 20250320494
    Abstract: The present invention relates to inhibitors, and compositions containing inhibitors, and uses of the same in the treatment or prevention of a disease related to a disorder of haemostasis, such as haemophilia.
    Type: Application
    Filed: June 1, 2023
    Publication date: October 16, 2025
    Inventors: Alan Victor WHITMORE, Julie BORGEL, Amy MCCARTHY, Graham CRAGGS, James LONGDEN, Ines DE SANTIAGO, Duncan BROWN, Ahmad Ali MORTAZAVI, Viviana MANNELLA, Muthusamy JAYARAMAN, Alexandre DEBACKER, Adrian MOGG
  • Inhibitors of expression and/or function
    Patent number: 12435337
    Abstract: The present invention relates to inhibitors, and compositions containing inhibitors, and uses of the same in the treatment or prevention of diabetes.
    Type: Grant
    Filed: April 19, 2024
    Date of Patent: October 7, 2025
    Assignee: E-Therapeutics PLC
    Inventors: Alan Victor Whitmore, Julie Borgel, Amy McCarthy, Graham Craggs, James Longden, Ines De Santiago, Duncan Brown, Ahmad Ali Mortazavi, Viviana Mannella, Muthusamy Jayaraman, Alexandre Debacker, Adrian Mogg
  • INHIBITORS OF EXPRESSION AND/OR FUNCTION
    Publication number: 20250304969
    Abstract: The present invention relates to inhibitors, and compositions containing inhibitors, and uses of the same in the treatment or prevention of diabetes.
    Type: Application
    Filed: June 11, 2025
    Publication date: October 2, 2025
    Inventors: Alan Victor WHITMORE, Julie BORGEL, Amy MCCARTHY, Graham CRAGGS, James LONGDEN, Ines DE SANTIAGO, Duncan BROWN, Ahmad Ali MORTAZAVI, Viviana MANNELLA, Muthusamy JAYARAMAN, Alexandre DEBACKER, Adrian MOGG
  • DOUBLE STRANDED NUCLEIC ACID COMPOUNDS INHIBITING ZPI
    Publication number: 20240352458
    Abstract: The present invention provides novel nucleic acid compound suitable for therapeutic use. Additionally, the present invention provides methods of making these compounds, as well as methods of using such compounds for the treatment of various diseases and conditions.
    Type: Application
    Filed: April 2, 2024
    Publication date: October 24, 2024
    Inventors: Amy MCCARTHY, Graham CRAGGS, James LONGDEN, Ines DE SANTIAGO, Duncan BROWN, Ahmad Ali MORTAZAVI, Viviana MANNELLA, Muthusamy JAYARAMAN, Alexandre DEBACKER, Adrian James MOGG
  • INHIBITORS OF EXPRESSION AND/OR FUNCTION
    Publication number: 20240336922
    Abstract: The present invention relates to inhibitors, and compositions containing inhibitors, and uses of the same in the treatment or prevention of diabetes.
    Type: Application
    Filed: April 19, 2024
    Publication date: October 10, 2024
    Inventors: Alan Victor WHITMORE, Julie BORGEL, Amy MCCARTHY, Graham CRAGGS, James LONGDEN, Ines DE SANTIAGO, Duncan BROWN, Ahmad Ali MORTAZAVI, Viviana MANNELLA, Muthusamy JAYARAMAN, Alexandre DEBACKER, Adrian MOGG
  • TMEM173 saRNA Compositions and Methods of Use
    Publication number: 20240175033
    Abstract: The disclosure relates to a saRNAs useful in upregulating the expression of a target gene and therapeutic compositions comprising the saRNA, wherein the target gene is TMEM173. Methods of using the saRNA and the therapeutic compositions are also provided.
    Type: Application
    Filed: March 25, 2022
    Publication date: May 30, 2024
    Applicant: MiNA Therapeutics Limited
    Inventors: Choon Ping Tan, Laura Sinigaglia, Valentin Gomez Martinez, Brid Ryan, Pål Sætrom, Siv Anita Hegre, Alexandre Debacker
  • OLIGONUCLEOTIDE CONJUGATE COMPOSITIONS AND METHODS OF USE
    Publication number: 20220281911
    Abstract: The disclosure relates to GalNAc moieties comprising at least one GalNAc monomer. The disclosure also relates to GalNAc-oligonucleotide conjugates comprising GalNAc moieties and oligonucleotides, e.g., saRNAs or siRNAs useful in regulating the expression of a target gene. Methods of using the GalNAc-oligonucleotide conjugates are also provided.
    Type: Application
    Filed: August 19, 2020
    Publication date: September 8, 2022
    Inventors: Alexandre Debacker, Jon Voutila, Lee Mitchell, Catherine M. McKeen
  • SIRT1-SARNA COMPOSITIONS AND METHODS OF USE
    Publication number: 20220211740
    Abstract: The disclosure relates to a saRNAs useful in upregulating the expression of the SIRT1 gene and therapeutic compositions comprising the saRNA. Methods of using the saRNA and the therapeutic compositions are also provided.
    Type: Application
    Filed: April 9, 2020
    Publication date: July 7, 2022
    Inventors: Pinelopi Andrikakou, Alexandre Debacker, Vikash Reebye