Abstract: Inventors have used FXYD7 knock-out mouse line and DRG-specific conditional Knock-out mice to demonstrate that the constitutive or DRG-specific knock-out of the FXYD7 gene specifically alleviate mechanical chronic pain induced by peripheral inflammation, but not by peripheral nerve lesions. They have also showed that: i) FXYD2 and FXYD7 are expressed by distinct and complementary somatosensory neuron subtypes suggesting specific functions in the somatosensory system; ii) FXYD7 is largely dispensable for neuronal differentiation and survival; iii) in FXYD7?/? animals, FXYD7 expression was not affected in the DRG. Accordingly, the present invention relates to a method for treating a subject suffering from a chronic pain disorder comprising a step of administrating said subject with a therapeutically effective amount of an inhibitor of FXYD7.