Abstract: Disclosed herein are multivalent vaccine or immunogenic compositions comprising one or more recombinant influenza virus hemagglutinin (HA), one or more recombinant influenza virus neuraminidase (NA), and an optional adjuvant. Also disclosed are methods of using the vaccine or immunogenic composition.

Abstract: Disclosed are multivalent vaccine or immunogenic compositions comprising influenza virus hemagglutinin (HA) from standard of care influenza virus strains, or ribonucleic acid molecules encoding the same; and one or more influenza virus HA identified or designed by machine learning, or one or more ribonucleic acid molecules that encode the influenza virus HA identified or designed by machine learning. Also disclosed are methods of using the vaccine or immunogenic compositions.

Abstract: An overdenture bar includes a U-shaped support beam configured to being coupled to a plurality of dental implants and extending generally above the mucus membrane of the gums. The U-shaped support beam has an anterior region and a pair of posterior extensions. At least one portion of the U-shaped support beam includes a plurality of retention elements extending generally normal to an outer surface of the U-shaped support beam in a plurality of directions. A method for producing a dental bar model on a CAD/CAM program to be fitted on a patient's upper or lower gingival surface includes the steps of selecting a longitudinal portion of the bar, adding protrusions to an upper portion of the bar and/or positioning a buccal finish line and a lingual finish between two boundary lines. The boundary lines illustrate the highest and lowest position of the finish lines.

Abstract: An overdenture bar includes a U-shaped support beam configured to being coupled to a plurality of dental implants and extending generally above the mucus membrane of the gums. The U-shaped support beam has an anterior region and a pair of posterior extensions. At least one portion of the U-shaped support beam includes a plurality of retention elements extending generally normal to an outer surface of the U-shaped support beam in a plurality of directions. A method for producing a dental bar model on a CAD/CAM program to be fitted on a patient's upper or lower gingival surface includes the steps of selecting a longitudinal portion of the bar, adding protrusions to an upper portion of the bar and/or positioning a buccal finish line and a lingual finish between two boundary lines. The boundary lines illustrate the highest and lowest position of the finish lines.