Patents by Inventor Alexandre Izmailov
Alexandre Izmailov has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230400392Abstract: The present disclosure provides a method of cell sedimentation and retention of target cells, for example circulating tumour cells, CTC, from a fluid sample onto a solid support. The method comprises placing a fluid medium comprising the target cells in a fluid chamber, the fluid chamber having an open end sealed against a surface of the solid support. The method further comprises subjecting the fluid medium to centrifugation within the fluid chamber to induce sedimentation of the target cells and promote cell adhesion to the surface of the solid support. The method further comprises, post-centrifugation, positioning a fluid absorbing element in the fluid chamber to remove fluid from the fluid chamber. The method further comprises controlling a flow rate of the fluid being absorbed by the fluid absorbing element such that the sedimented cells are not detached from the surface of the solid support.Type: ApplicationFiled: February 27, 2023Publication date: December 14, 2023Inventors: Alexandre Izmailov, Brian Pak, Tomoyuki Sen, Paul Timothy Smith
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Patent number: 11604120Abstract: The present disclosure provides a cell harvesting method for the efficient sedimentation and retention of cells from liquid samples onto a solid support with low cell losses and low impact on cell morphology.Type: GrantFiled: July 20, 2022Date of Patent: March 14, 2023Assignee: ANGLE EUROPE LIMITEDInventors: Alexandre Izmailov, Brian Pak, Tomoyuki Sen, Paul Timothy Smith
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Patent number: 11604119Abstract: The present disclosure provides a cell harvesting method and device for the efficient sedimentation and retention of cells from liquid samples onto a solid support with low cell losses and low impact on cell morphology. The device has two configurations, one being for use in a centrifuge to centrifuge the sample, a second for controlled release of the liquid post centrifugation. The device includes a base to hold a solid support that receives cells on a top surface thereof that releasably holds a fluid chamber which has a first opening with a gasket surrounding the opening with that bears against a top surface of the support. An opening receives the liquid sample and the gasket defines an area into which the targeted cells deposit. A first cap closes the second opening during centrifugation.Type: GrantFiled: July 20, 2022Date of Patent: March 14, 2023Assignee: ANGLE EUROPE LIMITEDInventors: Alexandre Izmailov, Brian Pak, Tomoyuki Sen, Paul Timothy Smith
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Publication number: 20230001407Abstract: A microporous substrate for detection of surface bound target analyte molecules includes a microporous substrate material having opposed surfaces and tapered micropores extending through the substrate with the micropores having wider openings on one side of the substrate compared to the other side. The micropores have bound therein analyte specific receptors complementary to the target molecules. When a liquid sample containing the target analyte molecules with optical probes attached to the target molecules is flowed through the substrate, they bind to their complementary analyte specific receptors and emit light. This microporous substrate structure gives an increase in the collection efficiency of light emitted from optical probes when the light is detected by a light detector spaced from the side of the microporous substrate facing the larger micropores openings compared to a light collection efficiency of light emitted from the optical probes when the micropores are straight and not tapered.Type: ApplicationFiled: August 12, 2022Publication date: January 5, 2023Inventors: ALEXANDRE IZMAILOV, DAVID ENGLERT, PAUL SMITH
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Patent number: 11435267Abstract: The present disclosure provides a cell harvesting method and device for the efficient sedimentation and retention of cells from liquid samples onto a solid support with low cell losses and low impact on cell morphology. The device has two configurations, one being for use in a centrifuge to centrifuge the sample, a second for controlled release of the liquid post centrifugation. The device includes a base to hold a solid support that receives cells on a top surface thereof that releasably holds a fluid chamber which has a first opening with a gasket surrounding the opening with that bears against a top surface of the support. An opening receives the liquid sample and the gasket defines an area into which the targeted cells deposit. A first cap closes the second opening during centrifugation.Type: GrantFiled: June 14, 2022Date of Patent: September 6, 2022Assignee: ANGLE EUROPE LIMITEDInventors: Alexandre Izmailov, Brian Pak, Tomoyuki Sen, Paul Timothy Smith
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Publication number: 20220226810Abstract: A microporous substrate for detection of surface bound target analyte molecules includes a microporous substrate material having opposed surfaces and tapered micropores extending through the substrate with the micropores having wider openings on one side of the substrate compared to the other side. The micropores have bound therein analyte specific receptors complementary to the target molecules. When a liquid sample containing the target analyte molecules with optical probes attached to the target molecules is flowed through the substrate, they bind to their complementary analyte specific receptors and emit light. This substrate structure gives an increase in the collection efficiency of light emitted from optical probes when the light is detected by a light detector spaced from the side of the substrate facing the larger micropores openings compared to a light collection efficiency of light emitted from the optical probes when the micropores are straight and not tapered.Type: ApplicationFiled: April 8, 2022Publication date: July 21, 2022Inventors: ALEXANDRE IZMAILOV, DAVID ENGLERT, PAUL SMITH
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Patent number: 11305274Abstract: The present disclosure provides a cartridge and method to move fluids within the cartridge that simplifies the design and removes the need for any internal valves or metering devices. The design is amenable to injection molded manufacturing lowering cost for large volume manufacturing. The design can be adapted to carry out both sample preparation and detection of biological substances including nucleic acids and proteins.Type: GrantFiled: February 22, 2018Date of Patent: April 19, 2022Assignee: ANGLE EUROPE LIMITEDInventors: Alexandre Izmailov, David Englert, Paul Smith
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Publication number: 20210237050Abstract: The present disclosure provides a cartridge and method to move fluids within the cartridge that simplifies the design and removes the need for any internal valves or metering devices. The design is amenable to injection molded manufacturing lowering cost for large volume manufacturing. The design can be adapted to carry out both sample preparation and detection of biological substances including nucleic acids and proteins.Type: ApplicationFiled: February 18, 2021Publication date: August 5, 2021Inventors: ALEXANDRE IZMAILOV, DAVID ENGLERT, PAUL SMITH
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Patent number: 10946375Abstract: The present disclosure provides a cartridge and method to move fluids within the cartridge that simplifies the design and removes the need for any internal valves or metering devices. The design is amenable to injection molded manufacturing lowering cost for large volume manufacturing. The design can be adapted to carry out both sample preparation and detection of biological substances including nucleic acids and proteins.Type: GrantFiled: April 11, 2016Date of Patent: March 16, 2021Assignee: Angle Europe LimitedInventors: Alexandre Izmailov, David Englert, Paul Smith
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Publication number: 20190054460Abstract: The present disclosure provides a cartridge and method to move fluids within the cartridge that simplifies the design and removes the need for any internal valves or metering devices. The design is amenable to injection molded manufacturing lowering cost for large volume manufacturing. The design can be adapted to carry out both sample preparation and detection of biological substances including nucleic acids and proteins.Type: ApplicationFiled: February 22, 2018Publication date: February 21, 2019Inventors: ALEXANDRE IZMAILOV, DAVID ENGLERT, PAUL SMITH
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Patent number: 9989525Abstract: The present disclosure provides a diffraction based biosensor containing at least two diffraction gratings. The first grating is referred to as an in-coupling diffraction grating and the coherent light source (laser) is directed to illuminate the in-coupling grating, and the biosensor is configured such that a selected order of the light beam diffracted from the in-coupling diffraction grating illuminates a second biosensor grating coated with analyte-specific receptors which are selected to preferentially bind with analytes being tested for that may or may not be located in a sample being tested.Type: GrantFiled: March 15, 2013Date of Patent: June 5, 2018Assignee: AXELA INC.Inventors: Alexandre Izmailov, Paul Timothy Smith
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Publication number: 20180117582Abstract: The present disclosure provides a cartridge and method to move fluids within the cartridge that simplifies the design and removes the need for any internal valves or metering devices. The design is amenable to injection molded manufacturing lowering cost for large volume manufacturing. The design can be adapted to carry out both sample preparation and detection of biological substances including nucleic acids and proteins.Type: ApplicationFiled: April 11, 2016Publication date: May 3, 2018Inventors: ALEXANDRE IZMAILOV, DAVID ENGLERT, PAUL SMITH
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Publication number: 20160377550Abstract: Systems and methods for differentiating the spectral response of various optical coatings between a transmitter and receiver. The system is effective in determining if an optical coating produces an authorized spectral response for determining if a product having that optical coating is authorized to be used with another product.Type: ApplicationFiled: September 12, 2016Publication date: December 29, 2016Inventors: Alexandre Izmailov, Peter Zosimadis
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Patent number: 9476826Abstract: Systems and methods for differentiating the spectral response of various optical coatings between a transmitter and receiver. The system is effective in determining if an optical coating produces an authorized spectral response for determining if a product having that optical coating is authorized to be used with another product.Type: GrantFiled: March 8, 2013Date of Patent: October 25, 2016Assignee: Smart Wave Technologies Corp.Inventors: Alexandre Izmailov, Peter Zosimadis
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Patent number: 9416399Abstract: The invention relates to a method for purification of nucleic acids, to a kit for performing the method according to the invention and to a new application of magnetic particles for purification of a biological sample. The method according to the invention comprises the following steps: a) accommodating of the sample in a first sample vessel in an aqueous solution and lysing of the sample under non-chaotropic conditions; suspending of first magnetic particles in the solution and inserting of the first sample vessel in a sample vessel holder, wherein the sample vessel is inserted in the annular interior space of a ring magnet associated with the sample vessel holder; separating of the solution from the magnetic particles; and isolating of the nucleic acids from the solution.Type: GrantFiled: March 6, 2014Date of Patent: August 16, 2016Assignee: Siemens Healthcare Diagnostics Inc.Inventors: Heike Euting, Guido Hennig, Alexandre Izmailov
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Publication number: 20140271363Abstract: The present disclosure provides a diffraction based biosensor containing at least two diffraction gratings. The first grating is referred to as an in-coupling diffraction grating and the coherent light source (laser) is directed to illuminate the in-coupling grating, and the biosensor is configured such that a selected order of the light beam diffracted from the in-coupling diffraction grating illuminates a second biosensor grating coated with analyte-specific receptors which are selected to preferentially bind with analytes being tested for that may or may not be located in a sample being tested.Type: ApplicationFiled: March 15, 2013Publication date: September 18, 2014Applicant: AXELA INC.Inventors: Alexandre IZMAILOV, Paul Timothy SMITH
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Publication number: 20140186236Abstract: The invention relates to a method for purification of nucleic acids, to a kit for performing the method according to the invention and to a new application of magnetic particles for purification of a biological sample. The method according to the invention comprises the following steps: a) accommodating of the sample in a first sample vessel in an aqueous solution and lysing of the sample under non-chaotropic conditions; suspending of first magnetic particles in the solution and inserting of the first sample vessel in a sample vessel holder, wherein the sample vessel is inserted in the annular interior space of a ring magnet associated with the sample vessel holder; separating of the solution from the magnetic particles; and isolating of the nucleic acids from the solution.Type: ApplicationFiled: March 6, 2014Publication date: July 3, 2014Applicant: Siemens Healthcare Diagnostics Inc.Inventors: Heike Euting, Guido Hennig, Alexandre Izmailov
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Patent number: 8703931Abstract: The invention relates to a method for purification of nucleic acids, to a kit for performing the method according to the invention and to a new application of magnetic particles for purification of a biological sample. The method according to the invention comprises the following steps: a) accommodating of the sample in a first sample vessel in an aqueous solution and lysing of the sample under non-chaotropic conditions; suspending of first magnetic particles in the solution and inserting of the first sample vessel in a sample vessel holder, wherein the sample vessel is inserted in the annular interior space of a ring magnet associated with the sample vessel holder; separating of the solution from the magnetic particles; and isolating of the nucleic acids from the solution.Type: GrantFiled: November 20, 2009Date of Patent: April 22, 2014Assignee: Siemens Healthcare Diagnostics Inc.Inventors: Heike Euting, Guido Hennig, Alexandre Izmailov
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Publication number: 20130188187Abstract: Systems and methods for differentiating the spectral response of various optical coatings between a transmitter and receiver. The system is effective in determining if an optical coating produces an authorized spectral response for determining if a product having that optical coating is authorized to be used with another product.Type: ApplicationFiled: March 8, 2013Publication date: July 25, 2013Inventors: Alexandre Izmailov, Peter Zosimadis
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Patent number: 8165716Abstract: A method of dispensing product includes determining by a processor if product loaded into a dispenser is authorized for use in the dispenser by identifying a reference indication associated with the product; in response to determination that the product is authorized, dispense a first amount of product; and in response to determination that the sheet product is unauthorized, dispense a second amount of sheet product, wherein the second amount of sheet product is different than the first amount. To determine if the sheet product is authorized, a pigment is excited to emit a light with an intensity signature. A portion of the intensity signature is measured and compared to a desired value. If the portion is substantially equal to the desired value, the sheet product is authenticated.Type: GrantFiled: December 11, 2009Date of Patent: April 24, 2012Assignee: Georgia-Pacific Consumer Products LPInventors: Harold J. Goeking, Daniel J. Geddes, Paul J. Ruthven, Kang Chang Yeh, Alexandre Izmailov, Paul Waterhouse, Panagiotis Zosimadis