Patents by Inventor Alexandre Kaoukhov

Alexandre Kaoukhov has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220347198
    Abstract: Methods for safe and effective treatment of inflammatory lesions of rosacea in a subject are described. The methods involve once daily topically applying to an affected skin area a topical composition containing ivermectin and a pharmaceutically acceptable carrier. It has been demonstrated that once daily topical treatment with ivermectin is significantly superior than twice-daily topical treatment with metronidazole in reducing inflammatory lesion counts.
    Type: Application
    Filed: July 7, 2022
    Publication date: November 3, 2022
    Inventors: Jean Jacovella, Jean-Paul Chappuis, Nathalie Sordello Wagner, Alexandre Kaoukhov, Michael Graeber, Laurence Salin, Michel Poncet, Philippe Briantais, Khaled Benkali
  • Publication number: 20210177882
    Abstract: Methods for safe and effective treatment of inflammatory lesions of rosacea in a subject are described. The methods involve once daily topically applying to an affected skin area a topical composition containing ivermectin and a pharmaceutically acceptable carrier. It has been demonstrated that once daily topical treatment with ivermectin is significantly superior than twice-daily topical treatment with metronidazole in reducing inflammatory lesion counts.
    Type: Application
    Filed: February 18, 2021
    Publication date: June 17, 2021
    Inventors: Jean JACOVELLA, Jean-Paul CHAPPUIS, Nathalie SORDELLO WAGNER, Alexandre KAOUKHOV, Michael GRAEBER, Laurence SALIN, Michel PONCET, Philippe BRIANTAIS, Khaled BENKALI
  • Publication number: 20200222432
    Abstract: Provided herein are methods of treating non-inflammatory lesions and symptoms thereof comprising administering to a subject in need thereof a therapeutically effective amount of (4S,4aS,5aR,12aS)-4-dimethylamino-3,10,12,12a-tetrahydroxy-7-[(methoxy(methyl)amino)-methyl]-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxylic acid amide or pharmaceutically acceptable salts thereof. In certain embodiments, a crystalline mono hydrochloride, mono mesylate, or mono sulfate salt of (4S,4aS,5aR,12aS)-4-(dimethylamino)-3,10,12,12a-tetrahydroxy-7-[(methoxy(methyl)amino)methyl]-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxylic acid amide is administered.
    Type: Application
    Filed: July 20, 2018
    Publication date: July 16, 2020
    Inventors: David BERK, Alexandre KAOUKHOV, Vilma SNIUKIENE, Carsten SCHMITZ
  • Publication number: 20200000835
    Abstract: Methods for safe and effective treatment of inflammatory lesions of rosacea in a subject are described. The methods involve once daily topically applying to an affected skin area a topical composition containing ivermectin and a pharmaceutically acceptable carrier. It has been demonstrated that once daily topical treatment with ivermectin is significantly superior than twice-daily topical treatment with metronidazole in reducing inflammatory lesion counts.
    Type: Application
    Filed: August 23, 2019
    Publication date: January 2, 2020
    Inventors: Jean JACOVELLA, Jean-Paul CHAPPUIS, Nathalie SORDELLO WAGNER, Alexandre KAOUKHOV, Michael GRAEBER, Laurence SALIN, Michel PONCET, Philippe BRIANTAIS, Khaled BENKALI
  • Patent number: 10206939
    Abstract: Methods and compositions for safe and effective treatment of papulopustular rosacea in a subject are described. The methods involve topically applying to an affected skin area a topical composition containing ivermectin and a pharmaceutically acceptable carrier. Treatment with ivermectin represents an innovative therapy that is more robust and effective than the conventional treatments.
    Type: Grant
    Filed: May 24, 2018
    Date of Patent: February 19, 2019
    Assignee: Galderma S.A.
    Inventors: Jean Jacovella, Jean-Paul Chappuis, Alexandre Kaoukhov, Michael Graeber, Michel Poncet, Philippe Briantais, Laurence Salin
  • Publication number: 20180264021
    Abstract: Methods and compositions for safe and effective treatment of papulopustular rosacea in a subject are described. The methods involve topically applying to an affected skin area a topical composition containing ivermectin and a pharmaceutically acceptable carrier. Treatment with ivermectin represents an innovative therapy that is more robust and effective than the conventional treatments.
    Type: Application
    Filed: May 24, 2018
    Publication date: September 20, 2018
    Inventors: Jean JACOVELLA, Jean-Paul CHAPPUIS, Alexandre KAOUKHOV, Michael GRAEBER, Michel PONCET, Philippe BRIANTAIS, Laurence SALIN
  • Publication number: 20180207188
    Abstract: Methods and compositions for safe and effective treatment of papulopustular rosacea in a subject are described. The methods involve topically applying to an affected skin area a topical composition containing ivermectin and a pharmaceutically acceptable carrier. Treatment with ivermectin represents an innovative therapy that is more robust and effective than the conventional treatments.
    Type: Application
    Filed: March 1, 2018
    Publication date: July 26, 2018
    Inventors: Jean JACOVELLA, Jean-Paul CHAPPUIS, Alexandre KAOUKHOV, Michael GRAEBER, Michel PONCET, Philippe BRIANTAIS, Laurence SALIN
  • Publication number: 20180177813
    Abstract: Methods for safe and effective treatment of inflammatory lesions of rosacea in a subject are described. The methods involve once daily topically applying to an affected skin area a topical composition containing ivermectin and a pharmaceutically acceptable carrier. It has been demonstrated that once daily topical treatment with ivermectin is significantly superior than twice-daily topical treatment with metronidazole in reducing inflammatory lesion counts.
    Type: Application
    Filed: February 22, 2018
    Publication date: June 28, 2018
    Inventors: Jean JACOVELLA, Jean-Paul CHAPPUIS, Nathalie SORDELLO WAGNER, Alexandre KAOUKHOV, Michael GRAEBER, Laurence SALIN, Michel PONCET, Philippe BRIANTAIS, Khaled BENKALI
  • Patent number: 9782425
    Abstract: Methods and compositions for safe and effective treatment of papulopustular rosacea in a subject are described. The methods involve topically applying to an affected skin area a topical composition containing ivermectin and a pharmaceutically acceptable carrier. Treatment with ivermectin represents an innovative therapy that is more robust and effective than the conventional treatments.
    Type: Grant
    Filed: July 8, 2014
    Date of Patent: October 10, 2017
    Assignee: Galderma S.A.
    Inventors: Jean Jacovella, Jean-Paul Chappuis, Alexandre Kaoukhov, Michael Graeber, Laurence Salin, Michel Poncet, Philippe Briantais
  • Publication number: 20170266138
    Abstract: Dapsone compositions can be useful for treating acne. The methods and formulations disclosed herein show efficacy for treating acne vulgaris and/or post inflammatory hyperpigmentation.
    Type: Application
    Filed: June 1, 2017
    Publication date: September 21, 2017
    Inventors: Kevin S. Warner, Ajay P. Parashar, Vijaya Swaminathan, Varsha Bhatt, Alexandre Kaoukhov
  • Publication number: 20170119703
    Abstract: Dapsone compositions can be useful for treating acne. The methods and formulations disclosed herein show efficacy for treating acne vulgaris and/or post inflammatory hyperpigmentation.
    Type: Application
    Filed: November 4, 2016
    Publication date: May 4, 2017
    Inventors: Kevin S. Warner, Ajay P. Parashar, Vijaya Swaminathan, Varsha Bhatt, Alexandre Kaoukhov
  • Patent number: 9457038
    Abstract: Administration of at least one compound of the family of the avermectins or of the family of the milbemycins, notably ivermectin, is useful for the treatment of ophthalmic pathologies, including ocular rosacea.
    Type: Grant
    Filed: May 22, 2014
    Date of Patent: October 4, 2016
    Assignee: GALDERMA S.A.
    Inventors: Alexandre Kaoukhov, Christophe Villard, Philippe Bouissou
  • Publication number: 20160184342
    Abstract: Methods for safe and effective treatment of inflammatory lesions of rosacea in a subject are described. The methods involve once daily topically applying to an affected skin area a topical composition containing ivermectin and a pharmaceutically acceptable carrier. It has been demonstrated that once daily topical treatment with ivermectin is significantly superior than twice-daily topical treatment with metronidazole in reducing inflammatory lesion counts.
    Type: Application
    Filed: July 8, 2014
    Publication date: June 30, 2016
    Inventors: Jean JACOVELLA, Jean-Paul CHAPPUIS, Nathalie SORDELLO WAGNER, Alexandre KAOUKHOV, Michael GRAEBER, Laurence SALIN, Michel PONCET, Philippe BRIANTAIS, Khaled BENKALI
  • Publication number: 20160175337
    Abstract: Methods and compositions for safe and effective treatment of papulopustular rosacea in a subject are described. The methods involve topically applying to an affected skin area a topical composition containing ivermectin and a pharmaceutically acceptable carrier. Treatment with ivermectin represents an innovative therapy that is more robust and effective than the conventional treatments.
    Type: Application
    Filed: December 17, 2015
    Publication date: June 23, 2016
    Inventors: Jean JACOVELLA, Jean-Paul CHAPPUIS, Alexandre KAOUKHOV, Michael GRAEBER, Michel PONCET, Philippe BRIANTAIS, Laurence SALIN
  • Publication number: 20160158263
    Abstract: Methods and compositions for safe and effective treatment of papulopustular rosacea in a subject are described. The methods involve topically applying to an affected skin area a topical composition containing ivermectin and a pharmaceutically acceptable carrier. Treatment with ivermectin represents an innovative therapy that is more robust and effective than the conventional treatments.
    Type: Application
    Filed: July 8, 2014
    Publication date: June 9, 2016
    Inventors: Jean JACOVELLA, Jian-Paul CHAPPUIS, Alexandre KAOUKHOV, Michael GRAEBER, Laurence SALIN, Michel PONCET, Philippe BRIANTAIS
  • Publication number: 20160143935
    Abstract: Methods for safe and effective treatment of inflammatory lesions of rosacea in a subject are described. The methods involve once daily topically applying to an affected skin area a topical composition containing ivermectin and a pharmaceutically acceptable carrier. It has been demonstrated that once daily topical treatment with ivermectin is significantly superior than twice-daily topical treatment with metronidazole in reducing inflammatory lesion counts.
    Type: Application
    Filed: December 17, 2015
    Publication date: May 26, 2016
    Inventors: Jean JACOVELLA, Jean-Paul CHAPPUIS, Nathalie SORDELLO WAGNER, Michael GRAEBER, Alexandre KAOUKHOV, Laurence SALIN, Michel PONCET, Philippe BRIANTAIS, Khaled BENKALI
  • Patent number: 9233117
    Abstract: Methods for safe and effective treatment of inflammatory lesions of rosacea in a subject are described. The methods involve once daily topically applying to an affected skin area a topical composition containing ivermectin and a pharmaceutically acceptable carrier. It has been demonstrated that once daily topical treatment with ivermectin is significantly superior than twice-daily topical treatment with metronidazole in reducing inflammatory lesion counts.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: January 12, 2016
    Assignee: Galderma S. A.
    Inventors: Jean Jacovella, Jean-Paul Chappuis, Nathalie Sordello Wagner, Michael Graeber, Alexandre Kaoukhov, Laurence Salin, Michel Poncet, Philippe Briantais, Khaled Benkali
  • Patent number: 9233118
    Abstract: Methods and compositions for safe and effective treatment of papulopustular rosacea in a subject are described. The methods involve topically applying to an affected skin area a topical composition containing ivermectin and a pharmaceutically acceptable carrier. Treatment with ivermectin represents an innovative therapy that is more robust and effective than the conventional treatments.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: January 12, 2016
    Assignee: Galderma S.A.
    Inventors: Jean Jacovella, Jean-Paul Chappuis, Alexandre Kaoukhov, Michael Graeber, Michel Poncet, Philippe Briantais, Laurence Salin
  • Patent number: 9125927
    Abstract: Pharmaceutical/dermatological compositions useful for the prevention/treatment of disorders of the skin, especially rosacea, contain thus effective amounts of at least one avermectin compound, e.g., ivermectin, and at least one azelaic acid compound or salt or derivative thereof, formulated into a physiologically acceptable medium therefor.
    Type: Grant
    Filed: September 27, 2013
    Date of Patent: September 8, 2015
    Assignee: GALDERMA S.A.
    Inventors: Alexandre Kaoukhov, Colette Pernin
  • Patent number: 8987218
    Abstract: Administration of at least one compound of the family of the avermectins or of the family of the milbemycins, notably ivermectin, is useful for the treatment of ophthalmic pathologies, including ocular rosacea.
    Type: Grant
    Filed: December 17, 2012
    Date of Patent: March 24, 2015
    Assignee: Galderma S.A.
    Inventors: Alexandre Kaoukhov, Christophe Villard, Philippe Bouissou