Patents by Inventor Alexandre LARIVEE

Alexandre LARIVEE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PHARMACOLOGICAL CORRECTORS OF RHODOPSIN AND USES THEREOF
    Publication number: 20260115174
    Abstract: Described herein are pharmacologic correctors of rhodopsin, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in treating disease.
    Type: Application
    Filed: October 27, 2025
    Publication date: April 30, 2026
    Inventors: Jillian R. Sanzone, Tao Zheng, Stacie S. Kim, Christopher Sinz, Jean-François Fournier, Alexandre Larivee, David Tong, Brandon Groves, Ludovic Deny, Kenneth Matthew Whitmore
  • Substituted pyrrolo[3,4-b]pyridines as PI3K-? inhibitors
    Patent number: 12581252
    Abstract: The present disclosure relates to novel compounds and pharmaceutical compositions thereof, and methods for inhibiting the activity of PI3K? enzymes with the compounds and compositions of formula I-1. The present disclosure further relates to, but is not limited to, methods for treating disorders associated with PI3K? signaling with the compounds and compositions of formula I-1.
    Type: Grant
    Filed: April 29, 2021
    Date of Patent: March 17, 2026
    Assignees: Relay Therapeutics, Inc., D. E. Shaw Research, LLC
    Inventors: Alessandro Boezio, Lucian V. Dipietro, Hakan Gunaydin, Thomas H. McLean, Levi Charles Thomas Pierce, Fabrizio Giordanetto, Yakov Pechersky, Megan Bertrand-Laperle, Alexandre Larivee, Kashif Tanveer, Michael Paul DeNinno, Tarek Mohamed
  • GPR6 INVERSE AGONISTS
    Publication number: 20260042755
    Abstract: Provided herein, is a compound of Formula (I) or a pharmaceutically acceptable salt thereof, wherein Cy, Hy, X, Y, Ra, Rb, Rc, and Rd are defined herein as well as compositions and methods of use thereof.
    Type: Application
    Filed: August 10, 2023
    Publication date: February 12, 2026
    Inventors: Andrew GOOD, Michael WOOD, Vinod F. PATEL, Mark SYLVESTER, Alexandre LARIVEE, Tarek MOHAMED, Maksym DIACHENKO, David Fabian LEON-RAYO, Amol Pandharianath JADHAV, Shekhar Reddy DURUPALA, Lea CONSTANTINEAU-FORGET
  • PI3K-ALPHA INHIBITORS AND METHODS OF USE THEREOF
    Publication number: 20260035335
    Abstract: The present disclosure relates to novel compounds and pharmaceutical compositions thereof, and methods for inhibiting the activity of PI3K? enzymes with the compounds and compositions of the disclosure. The present disclosure further relates to, but is not limited to, methods for treating disorders associated with PI3K? signaling with the compounds and compositions of the disclosure.
    Type: Application
    Filed: August 11, 2025
    Publication date: February 5, 2026
    Inventors: Yue Pan, Alessandro Boezio, Cary Griffin Fridrich, Elaine B. Krueger, Demetri T. Moustakas, Kevin David Raynor, Kelley C. Shortsleeves, Thomas H. McLean, Michael Paul DeNinno, Christopher Thomson, Alexandre Larivee, Andrew J. Burnie, Bren-Jordan Atienza, Christian Perreault, Gaetan Maertens, Tarek Mohamed, Thomas Lepitre, Erich W. Baum, Hakan Gunaydin
  • PI3K-ALPHA INHIBITORS AND METHODS OF USE THEREOF
    Publication number: 20250313524
    Abstract: The present disclosure relates to novel compounds and pharmaceutical compositions thereof, and methods for inhibiting the activity of PI3K? enzymes with the compounds and compositions of the disclosure. The present disclosure further relates to, but is not limited to, methods for treating disorders associated with PI3K? signaling with the compounds and compositions of the disclosure.
    Type: Application
    Filed: May 10, 2023
    Publication date: October 9, 2025
    Inventors: Yue Pan, Alessandro Boezio, Cary Griffin Fridrich, Elaine B. Krueger, Demetri T. Moustakas, Kevin David Raynor, Kelley C. Shortsleeves, Thomas H. McLean, Michael Paul DeNinno, Christopher Thomson, Alexandre Larivee, Andrew J. Burnie, Bren-Jordan Atienza, Christian Perreault, Gaetan Maertens, Tarek Mohamed, Thomas Lepitre, Erich W. Baum, Hakan Gunaydin
  • PI3K-ALPHA INHIBITORS AND METHODS OF USE THEREOF
    Publication number: 20250090540
    Abstract: The present disclosure relates to novel compounds and pharmaceutical compositions thereof, and methods for inhibiting the activity of PI3K? enzymes with the compounds and compositions of the disclosure. The present disclosure further relates to, but is not limited to, methods for treating disorders associated with PI3K? signaling with the compounds and compositions of the disclosure.
    Type: Application
    Filed: September 9, 2022
    Publication date: March 20, 2025
    Inventors: Alessandro BOEZIO, Alexander M. TAYLOR, Hakan GUNAYDIN, Hanmo ZHANG, Kevin David RAYNOR, Kelley C. SHORTSLEEVES, Lucian V. DIPIETRO, Levi Charles Thomas PIERCE, Nicolas PABON, Thomas H. MCLEAN, Fabrizio GIORDANETTO, Yakov PECHERSKY, Qi WANG, Alexandre LARIVEE, Fei CHEN, Gaetan MAERTENS, Johanne OUTIN, Megan BERTRAND-LAPERLE, Mohan PAL, Sampada CHITALE, Michael Paul DENINNO
  • Substituted isoindolines as PI3K-alpha inhibitors
    Patent number: 12219327
    Abstract: The present disclosure relates to novel compounds and pharmaceutical compositions thereof, and methods for inhibiting the activity of PI3K-? enzymes with the compounds and compositions of the disclosure. The present disclosure further relates to, but is not limited to, methods for treating disorders associated with PI3K-? signaling with the compounds and compositions of the disclosure.
    Type: Grant
    Filed: June 9, 2023
    Date of Patent: February 4, 2025
    Assignees: Relay Therapeutics, Inc., D. E. Shaw Research, LLC
    Inventors: Lucian V. Dipietro, Kelley C. Shortsleeves, Thomas H. Mclean, Alexandre Larivee, Fabrizio Giordanetto, André Lescarbeau, Alessandro Boezio, Hanmo Zhang
  • PI3K-ALPHA INHIBITORS AND METHODS OF USE THEREOF
    Publication number: 20250019380
    Abstract: The present disclosure relates to novel compounds and pharmaceutical compositions thereof, and methods for inhibiting the activity of PI3K? enzymes with the compounds and compositions of the disclosure. The present disclosure further relates to, but is not limited to, methods for treating disorders associated with PI3K? signaling with the compounds and compositions of the disclosure.
    Type: Application
    Filed: July 13, 2022
    Publication date: January 16, 2025
    Inventors: Alessandro BOEZIO, Alexander M. TAYLOR, Cary Griffin FRIDRICH, Hakan GUNAYDIN, Lucian V. DIPIETRO, Levi Charles Thomas PIERCE, Mary M. MADER, Ravi KURUKULASURIYA, Thomas H. MCLEAN, Yue PAN, Michael Paul DENINNO, Alexandre LARIVEE, Andrew j. BURNIE, Caleb MEDENA, Gaetan MAERTENS, Kashif TANVEER, Mohan PAL, Tarek MOHAMED, Thomas LEPITRE, Bren-Jordan ATIENZA, Naresh VEMULA, Shorena GELOZIA
  • PI3K-ALPHA INHIBITORS AND METHODS OF USE THEREOF
    Publication number: 20240287058
    Abstract: The present disclosure relates to novel compounds and pharmaceutical compositions thereof, and methods for inhibiting the activity of PI3K-? enzymes with the compounds and compositions of the disclosure. The present disclosure further relates to, but is not limited to, methods for treating disorders associated with PI3K-? signaling with the compounds and compositions of the disclosure.
    Type: Application
    Filed: April 29, 2021
    Publication date: August 29, 2024
    Inventors: Alessandro BOEZIO, Lucian V. DIPIETRO, Cary Griffin FRIDRICH, Hakan GUNAYDIN, Ravi KURUKULASURIYA, André LESCARBEAU, Mary M. MADER, Thomas H. MCLEAN, Levi CharlesThomas PIERCE, Kevin David RAYNOR, Kelley C. SHORTSLEEVES, Yong TANG, Alexander M. TAYLOR, W. Patrick WALTERS, Hanmo ZHANG, Fabrizio GIORDANETTO, Yakov PECHERSKY, Qi WANG, Bren-Jordan ATIENZA, Megan BERTRAND-LAPERLE, Andrew J. BURNIE, Fei CHEN, Sampada CHITALE, Shorena GELOZIA, Jean-Benoit GIGUERE, Elodie LANDAGARAY, Alexandre LARIVEE, Thomas LEPITRE, Gaetan MAERTENS, Johanne OUTIN, Mohan PAL, Claudio STURINO, Kashif TANVEER, Rakesh THORAT, Naresh VEMULA, Elaine B. KRUEGER, Yue PAN, Michael Paul DENINNO, Yves BOUSQUET, Antoine JOBIN-DES LAURIERS, Jessica LEE, Tarek MOHAMED
  • PI3K-ALPHA INHIBITORS AND METHODS OF USE THEREOF
    Publication number: 20230353959
    Abstract: The present disclosure relates to novel compounds and pharmaceutical compositions thereof, and methods for inhibiting the activity of PI3K-? enzymes with the compounds and compositions of the disclosure. The present disclosure further relates to, but is not limited to, methods for treating disorders associated with PI3K-? signaling with the compounds and compositions of the disclosure.
    Type: Application
    Filed: June 9, 2023
    Publication date: November 2, 2023
    Inventors: Lucian V. DIPIETRO, Kelley C. SHORTSLEEVES, Thomas H. MCLEAN, Alexandre LARIVEE, Fabrizio GIORDANETTO