Abstract: The present invention relates to silk fibroin bioinks specifically formulated for use in 3D bioprinting and the production of ex-vivo models capable of supporting hematopoiesis and the production of platelets and blood cells.

Abstract: The present invention relates to a polypeptide comprising 7 ?-strands A, B, C, D, E, F, and G sequentially connected together by connecting chains of amino acids, and a first ?-helix sequentially located on the EF chain between ?-strands E and F, wherein the ?-strands are arranged so as to form a first ?-sheet comprising ?-strands A, B, D, and E, and a second ?-sheet comprising ?-strands C, F and G, said first and second ?-sheets being covalently bonded together so as to form a first Ig domain; wherein the EF chain between ?-strands E and F comprises the sequence X1-X2-X3-X4-K5H6 (SEQ ID NO:98), and X1, X3 and X4 are each independently any amino acid residue, characterized in that X2 is selected from the group consisting of A, G, I, V, L, R, S, T, Q, P, N, M, H, W, and pharmaceutically acceptable salts, stereoisomers, tautomers, solvates, and prodrugs thereof.

Abstract: A measuring device for measuring a width (W) between a first edge (4) and a second edge (5) of spaced apart opposed edges (4, 5) of a slot (16) in a product (1?), comprising: a measuring part (18), with a measuring detector and a display (28), and provided with a first tab (37) configured to enter into the slot (16), and a slide (29), defining a longitudinal axis (X), being arranged so as to be adjustable relative to the measuring part (18) along the longitudinal axis (X), and provided with a second tab (46) being configured to enter into the slot (16). The slide (29) is adjusted so that a first surface (44) of the first tab (37) contacts the first edge (4) and a second surface (49) of the second tab (46) contacts the second edge (5). A distance (d) between the first surface (44) and the second surface (49) corresponding to the width (W) is detected by the measuring detector, and the value of the width (W) is displayed by the display (28).

Abstract: A method and an apparatus are disclosed for simultaneously cleaning multiple teeth, such as one or both dental arches are disclosed. The Dental Cleaning Apparatus includes a cleaning engine enclosed in a main housing, a fluid tube, and a mouthpiece. The cleaning engine includes a fluid circuit having a number of pumps and solenoid valves, and a programmable controller to control the solenoid valves and other operations. The fluid tube includes a number of separate tubes for injection and evacuation of cleaning fluid from the interior of the mouthpiece. The mouthpiece is generally made from a flexible and supple material, such as silicone, and may have bristles of various shapes. The cleaning engine alternates the mouthpiece between a relaxation state and a contraction state to effectively scrub the surface of all enclosed teeth simultaneously. It may automatically learn and adjust the vacuum pressure needed for each user to optimize cleaning.

Abstract: The present invention relates to a polypeptide comprising 7 ?-strands A, B, C, D, E, F, and G sequentially connected together by connecting chains of amino acids, and a first ?-helix sequentially located on the EF chain between ?-strands E and F, wherein the ?-strands are arranged so as to form a first ?-sheet comprising ?-strands A, B, D, and E, and a second ?-sheet comprising ?-strands C, F and G, said first and second ?-sheets being covalently bonded together so as to form a first Ig domain; wherein the EF chain between ?-strands E and F comprises the sequence X1-X2-X3-X4-K5H6 (SEQ ID NO:98), and X1, X3 and X4 are each independently any amino acid residue, characterized in that X2 is selected from the group consisting of A, G, I, V, L, R, S, T, Q, P, N, M, H, W, and pharmaceutically acceptable salts, stereoisomers, tautomers, solvates, and prodrugs thereof

Abstract: A method and an apparatus are disclosed for simultaneously cleaning multiple teeth, such as one or both dental arches. The Dental Cleaning Apparatus (DCA) includes a cleaning engine enclosed in a main housing, a fluid tube, and a mouthpiece. The cleaning engine includes a fluid circuit having a number of pumps and solenoid valves, and a programmable controller to control the solenoid valves and other operations. The fluid tube includes a number of separate tubes for injection and evacuation of cleaning fluid from the interior of mouthpiece. The mouthpiece is generally made from a flexible and supple material, such as silicone, and may have bristles of various shapes. The cleaning engine alternates the mouthpiece between a relaxation state and a contraction state to effectively scrub the surface of all enclosed teeth simultaneously. It may automatically learn and adjust the vacuum pressure needed for each user to optimize cleaning.

Abstract: A method and an apparatus are disclosed for simultaneously cleaning multiple teeth, such as one or both dental arches. The Dental Cleaning Apparatus (DCA) includes a cleaning engine enclosed in a main housing, a fluid tube, and a mouthpiece. The cleaning engine includes a fluid circuit having a number of pumps and solenoid valves, and a programmable controller to control the solenoid valves and other operations. The fluid tube includes a number of separate tubes for injection and evacuation of cleaning fluid from the interior of mouthpiece. The mouthpiece is generally made from a flexible and supple material, such as silicone, and may have bristles of various shapes. The cleaning engine alternates the mouthpiece between a relaxation state and a contraction state to effectively scrub the surface of all enclosed teeth simultaneously. It may automatically learn and adjust the vacuum pressure needed for each user to optimize cleaning.

Abstract: The present invention relates to a macromolecule-loaded bioresorbable crosslinked polymer wherein the polymer is obtainable from the polymerization of: (i) at least one monomer of formula (I) (CH2?CR1)CO—K wherein: —K represents O—Z or NH—Z, Z representing (CR2R3)m—CH3, (CH2—CH2—O)m—H, (CH2—CH2—O)m—CH3, (CH2)m—NR4R5 with m representing an integer from 1 to 30; —R1, R2, R3, R4 and R5 independently represent H or a C1-C6 alkyl; and (ii) at least one bio-resorbable block copolymer cross-linker, and wherein the macromolecule is chosen in the group consisting of proteins and nucleic acids.

Abstract: The present invention relates to a polymer obtained from the polymerization of: (i) at least one monomer of formula (I) (CH2?CR1)CO—K (1) wherein: —K represents O—Z or N H—Z, Z representing (CR2R3)m-CH3, (CH2—CH2—O)m-H, (CH2—CH2—O)m-CH3, (CH2)m-NR4R5 with m representing an integer from 1 to 30; —R1, R2, R3, R4 and R5 independently represent H or a C1-C6 alkyl; (ii) at least between 0.1 and 50% mol, advantageously between 1 and 30% mol, more advantageously between 1 and 20 mol % of a cyclic monomer having a exomethylene group of formula (II) wherein: — R6, R7, R8 and R9 represent independently H or a C5-C7 aryl group or R6 and R9 are absent and R7 and R8 form together with the carbon atom on which they are bonded a C5-C7 aryl group; —i and j represent independently an integer chosen between 0 and 2; —X represents either O or X is not present and in this latter case, CR6R7 and CR8R9 are linked via a single bond C—C and (iii) at least one bio-resorbable block copolymer cross-linker.

Abstract: The present invention relates to a polymer obtained from the polymerization of: (i) at least one monomer of formula (I) (CH2?CR1)CO—K (I) wherein: K represents 0-Z or NH—Z, Z representing (CR2R3)m—CH3, (CH2—CH2—O)m—H, (CH2—CH2—O)m—CH3, (CH2)m—NR4R5 with m representing an integer from 1 to 30; R1, R2, R3, R4 and R5 independently represent H or a C1-C6 alkyl; and (ii) at least one bio-resorbable block copolymer cross-linker.

Abstract: The present invention provides a composition of the formula: [FGF21-1st Linker]-[Ab]-[2nd-Linker-Ex4]; wherein FGF21 is an FGF21 homologue; and Ex4 is an Exendin4 homologue; and Ab is an aldolase catalytic antibody or antigen binding portion thereof; and the 1st linker is covalently attached to the side chain of a protein-linking residue in FGF21 and to a combining site of the antibody, and the 2nd linker is covalently attached to the side chain of a peptide-linking residue in Ex4 and to a combining site of the antibody, and wherein the first and second linker are the same or different. Various uses of the compounds are provided, including methods to prevent or treat diabetes or diabetes-related conditions.

Abstract: The present invention relates to Multifunctional Antibody Conjugates, comprising an antibody or antigen binding portion thereof, comprising at least a fragment of a light chain constant kappa region (CL?) comprising K188 according to Kabat numbering; a linker comprising the formula X-Y-Z, wherein Z is a group is covalently connected to the antibody through the side chain of K188, Y is a linear or branched biologically compatible connecting chain, and X is a group covalently connected to at least one Effector Moiety. The invention further provides specific MAC compounds and compositions of the invention.

Abstract: An injectable biomaterial containing a non-aqueous solvent suitable for injection to a human being and nanoparticles made of a polymer that is insoluble in water and insoluble in the non-aqueous solvent, in which the nanoparticles are loaded with a drug or a biological agent. The injectable biomaterial is suitable for occluding normal or malformative blood vessels or non-circulating cavities, or for necrosing tumors.

Abstract: The present invention relates to a macromolecule-loaded bioresorbable crosslinked polymer wherein the polymer is obtainable from the polymerization of: (i) at least one monomer of formula (I) (CH2?CR1)CO—K wherein: —K represents O-Z or NH-Z, Z representing (CR2R3)m—CH3, (CH2—CH2—O)m—H, (CH2—CH2—O)m—CH3, (CH2)m—NR4R5 with m representing an integer from 1 to 30; —R1, R2, R3, R4 and R5 independently represent H or a C1-C6 alkyl; and (ii) at least one bio-resorbable block copolymer cross-linker, and wherein the macromolecule is chosen in the group consisting of proteins and nucleic acids.

Abstract: The present invention relates to a polymer obtained from the polymerization of: (i) at least one monomer of formula (I) (CH2?CR1)CO—K (1) wherein: K represents O—Z or NH—Z, Z representing (CR2R3)m-CH3, (CH2—CH2—O)m-H, (CH2—CH2—O)m-CH3, (CH2)m-NR4R5 with m representing an integer from 1 to 30; R1, R2, R3, R4 and R5 independently represent H or a C1-C6 alkyl; (ii) at least between 0.1 and 50% mol, advantageously between 1 and 30% mol, more advantageously between 1 and 20 mol % of a cyclic monomer having a exomethylene group of formula (II) wherein: R6, R7, R8 and R9 represent independently H or a C5-C7 aryl group or R6 and R9 are absent and R7 and R8 form together with the carbon atom on which they are bonded a C5-C7 aryl group; i and j represent independently an integer chosen between 0 and 2; X represents either O or X is not present and in this latter case, CR6R7 and CR8R9 are linked via a single bond C—C and (iii) at least one bio-resorbable block copolymer cross-linker.

Abstract: The present invention relates to a polymer obtained from the polymerization of: (i) at least one monomer of formula (I) (CH2?CR1)CO—K (I) wherein: K represents 0-Z or NH—Z, Z representing (CR2R3)m—CH3, (CH2—CH2—O)m—H, (CH2—CH2—O)m—CH3, (CH2)m—NR4R5 with m representing an integer from 1 to 30; R1, R2, R3, R4 and R5 independently represent H or a C1-C6 alkyl; and (ii) at least one bio-resorbable block copolymer cross-linker.

Abstract: The present invention relates to Multifunctional Antibody Conjugates, comprising an antibody or antigen binding portion thereof, comprising at least a fragment of a light chain constant kappa region (CL?) comprising K188 according to Kabat numbering; a linker comprising the formula X-Y-Z, wherein Z is a group is covalently connected to the antibody through the side chain of K188, Y is a linear or branched biologically compatible connecting chain, and X is a group covalently connected to at least one Effector Moiety. The invention further provides specific MAC compounds and compositions of the invention.

Abstract: The invention relates to an injectable biomaterial. The injectable biomaterial of the invention comprises a non aqueous solvent which is compatible for injection to human being and nanoparticles made of a polymer which is insoluble in water and insoluble in said non aqueous solvent, said nanoparticles being loaded with a drug or a biological agent. The injectable biomaterial of the invention is particularly appropriate for occluding normal or malformative blood vessels or non circulating cavities or for necrosing tumors.

Abstract: A method is provided for estimating the components of the force torsor that are applied to a bearing, which method provides for the measurement of a vector (Vm) of N deformations and for the use of a physical model linking a vector (Q) of at most N representative values of the components of the torsor with a deformation measurement vector, the method comprises the following iterative steps: introduction of a vector (Q) of representative values into the model in order to calculate a deformation measurement vector (Vc); and carrying out a pertinence test (T) between the deformation measurement vector (Vc) which is calculated and the measured vector (Vm); if the test (T) is negative, establishing at least one new vector (Q) of representative values to be introduced into the model according to the result of the test; or if the test (T) is positive, storing the vector (Q) of introduced values; wherein the estimated components of the force torsor are established according to at least one stored vector (Q) of values

Abstract: The present invention provides a biodegradable biopolymer matrix for surgical and/or therapeutic use comprising chitosan hydrochloride and dextran dialdehyde is in the ratio of 1:1 to 1:2. The invention further provides a process for preparing the biopolymer matrix and a kit for a surgical and/or therapeutic use comprising the biopolymer matrix.