Patents by Inventor Alexandre LE FLOHIC

Alexandre LE FLOHIC has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

Salt of 3-[(3-{[4-(4-morpholinylmethyl)-1H-pyrrol-2-yl]methylene}-2-oxo-2,3-dihydro-1H-indol-5-yl)methyl]-1,3-thiazolidine-2,4-dione, its preparation, and formulations containing it

Patent number: 10245270

Abstract: 3-[(3-{[4-(4-morpholinylmethyl)-1H-pyrrol-2-yl]methylene}-2-oxo-2,3-dihydro-1H-indol-5-yl)methyl]-1,3-thiazolidine-2,4-dione methanesulphonate of formula (II): Medicinal products containing the same which are useful in treating cancer.

Type: Grant

Filed: September 4, 2018

Date of Patent: April 2, 2019

Assignee: LES LABORATOIRES SERVIER

Inventors: Alexandre Le Flohic, Jérôme Guidotti, Philippe Letellier
SALT OF 3-[(3-{[4-(4-MORPHOLINYLMETHYL)-1H-PYRROL-2-YL]METHYLENE}-2-OXO- 2,3-DIHYDRO-1H-INDOL-5-YL)METHYL]-1,3-THIAZOLIDINE-2,4-DIONE, ITS PREPARATION, AND FORMULATIONS CONTAINING IT

Publication number: 20180369252

Abstract: 3-[(3-{[4-(4-morpholinylmethyl)-1H-pyrrol-2-yl]methylene}-2-oxo-2,3-dihydro-1H-indol-5-yl)methyl]-1,3-thiazolidine-2,4-dione methanesulphonate of formula (II): Medicinal products containing the same which are useful in treating cancer.

Type: Application

Filed: September 4, 2018

Publication date: December 27, 2018

Inventors: Alexandre LE FLOHIC, Jérôme GUIDOTTI, Philippe LETELLIER
SALT OF 3-[(3-{[4-(4-MORPHOLINYLMETHYL)-1H-PYRROL-2-YL]METHYLENE}-2-OXO-2,3-DIHYDRO-1H-INDOL-5-YL)METHYL]-1,3-THIAZOLIDINE-2,4-DIONE, ITS PREPARATION, AND FORMULATIONS CONTAINING IT

Publication number: 20180207171

Abstract: 3-[(3-{[4-(4-morpholinylmethyl)-1H-pyrrol-2-yl]methylene}-2-oxo-2,3-dihydro-1H-indol5-yl)methyl]-1,3-thiazolidine-2,4-dione methanesulphonate of formula (II): Medicinal products containing the same which are useful in treating cancer.

Type: Application

Filed: February 14, 2018

Publication date: July 26, 2018

Inventors: Alexandre LE FLOHIC, Jérôme GUIDOTTI, Philippe LETELLIER
Salt of 3-[(3-{[4-(4-morpholinylmethyl)-1H-pyrrol-2-yl]methylene}-2-oxo-2,3-dihydro-1H-indol-5-yl)methyl]-1,3-thiazolidine-2,4-dione, its preparation, and formulations containing I

Patent number: 9925195

Abstract: 3-[3-{[4-(4-morpholinylmethyl)-1H-pyrrol-2-yl]methylene}-2-oxo-2,3-dihydro-1H-indol-5-yl)methyl]-1,3-thiazolidine-2,4-dione methanesulphonate of formula (II): Medicinal products containing the same which are useful in treating cancer.

Type: Grant

Filed: July 11, 2014

Date of Patent: March 27, 2018

Assignee: LES LABORATOIRES SERVIER

Inventors: Alexandre Le Flohic, Jérôme Guidotti, Philippe Letellier
SALT OF 3-[(3--2-OXO-2,3-DIHYDRO-1H-INDOL-5-YL)METHYL]-1,3-THIAZOLIDINE-2,4-DIONE, ITS PREPARATION, AND FORMULATIONS CONTAINING I

Publication number: 20160151378

Abstract: 3-[3-{[4-(4-morpholinylmethyl)-1H-pyrrol-2-yl]methylene}-2-oxo-2,3-dihydro-1H-indol-5-yl)methyl]-1,3-thiazolidine-2,4-dione methanesulphonate of formula (II): Medicinal products containing the same which are useful in treating cancer.

Type: Application

Filed: July 11, 2014

Publication date: June 2, 2016

Inventors: Alexandre LE FLOHIC, Jérôme GUIDOTTI, Philippe LETELLIER
Process for the synthesis of 7,8-dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one compounds, and application in the synthesis of ivabradine

Patent number: 8927708

Abstract: Process for the synthesis of the compound of formula (I): wherein R represents a para-methoxybenzyl (PMB) group or the following group: Application in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid.

Type: Grant

Filed: March 24, 2014

Date of Patent: January 6, 2015

Assignee: Les Laboratoires Servier

Inventor: Alexandre Le Flohic
Process for the synthesis of 3,4-dimethoxybicyclo[4.2.0]OCTA-1,3,5-triene-7-carbonitrile, and application in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid

Patent number: 8859763

Abstract: Process for the synthesis of the compound of formula (I): Application in the synthesis of ivabradine, addition salts thereof with a pharmaceutically acceptable acid and hydrates thereof.

Type: Grant

Filed: May 14, 2014

Date of Patent: October 14, 2014

Assignee: Les Laboratoires Servier

Inventors: Lucile Vaysse-Ludot, Alexandre Le Flohic, Michel Vaultier, Mathieu Pucheault, Thomas Kaminski
PROCESS FOR THE SYNTHESIS OF 7,8-DIMETHOXY-1,3-DIHYDRO-2H-3-BENZAZEPIN-2-ONE COMPOUNDS, AND APPLICATION IN THE SYNTHESIS OF IVABRADINE

Publication number: 20140296512

Abstract: Process for the synthesis of the compound of formula (I): wherein R represents a para-methoxybenzyl (PMB) group or the following group: Application in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid.

Type: Application

Filed: March 24, 2014

Publication date: October 2, 2014

Applicant: LES LABORATOIRES SERVIER

Inventor: Alexandre LE FLOHIC
Process for the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid

Patent number: 8835627

Abstract: Process for the synthesis of ivabradine of formula (I): and addition salts thereof with a pharmaceutically acceptable acid.

Type: Grant

Filed: March 25, 2013

Date of Patent: September 16, 2014

Assignee: Les Laboratoires Servier

Inventors: Alexandre Le Flohic, Mathieu Grandjean
PROCESS FOR THE SYNTHESIS OF IVABRADINE AND ADDITION SALTS THEREOF WITH A PHARMACEUTICALLY ACCEPTABLE ACID

Publication number: 20130261298

Abstract: Process for the synthesis of ivabradine of formula (I): and addition salts thereof with a pharmaceutically acceptable acid.

Type: Application

Filed: March 25, 2013

Publication date: October 3, 2013

Applicant: LES LABORATOIRES SERVIER

Inventors: Alexandre LE FLOHIC, Mathieu GRANDJEAN