Abstract: Described herein are phenoxy-pyridyl-pyrimidine compounds with inositol requiring enzyme 1 (IRE1) modulation activity or function having the Formula I structure or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, and with the substituents and structural features described herein. Also described are pharmaceutical compositions and medicaments that include the Formula I compounds, as well as methods of using such IRE1 modulators, alone and in combination with other therapeutic agents, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.

Abstract: The invention provides benzene sulfonamides and pharmaceutically acceptable salt thereof that are useful as sodium channel blockers for the treatment of, for example, pain.

Abstract: Described herein are phenoxy-pyridazinyl-pyrimidine or phenoxy-pyrimidinyl-pyrimidine compounds and pharmaceutically acceptable salts thereof for use in the treatment of Ire1-mediated diseases and cancer.

Abstract: A device is provided for determining an RF coverage quality of a wireless mesh network at a given location. The device includes a communication module, a processing module, and a visual interface. The communication module is configured to communicate with nearby neighbours in the wireless mesh network. The processing module is configured to detect and calculate good neighbours having an RF signal strength above a first predetermined threshold, and a tickle success rate above a second predetermined threshold. Methods to install and validate the installation of a wireless electric meter and a passive antenna are also provided.

Abstract: The invention provides benzene sulfonamides and pharmaceutically acceptable salt thereof that are useful as sodium channel blockers for the treatment of, for example, pain.

Abstract: The invention provides a compound of formula I: or a pharmaceutically acceptable salt thereof, wherein the variables X, Y1—Y5, R1, R2, R3, R4, and Het have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.

Abstract: A device is provided for determining an RF coverage quality of a wireless mesh network at a given location. The device includes a communication module, a processing module, and a visual interface. The communication module is configured to communicate with nearby neighbours in the wireless mesh network. The processing module is configured to detect and calculate good neighbours having an RF signal strength above a first predetermined threshold, and a tickle success rate above a second predetermined threshold. Methods to install and validate the installation of a wireless electric meter and a passive antenna are also provided.

Abstract: The invention provides a compound of formula I: or a pharmaceutically acceptable salt thereof, wherein the variables X, Y1—Y5, R1, R2, R3, R4, and Het have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.

Abstract: The invention provides a compound as described herein or a pharmaceutically acceptable salt thereof, and compositions containing such compounds and methods for using such compounds and compositions.

Abstract: The present document describes an amusement vehicle for interacting with at least another amusement vehicle in an amusement environment, the amusement vehicle comprising: a chassis; a set of wheels for rotatably supporting the chassis on a ground surface; a motor mounted on the chassis for propelling the chassis on the ground surface; a controller operably connected to the motor for controlling the motor; and at least one of: a receiver mounted on the chassis for receiving a first directional signal of the at least another amusement vehicle only when the at least another amusement vehicle is in substantial alignment with the receiver; and a transmitter mounted on the chassis for transmitting a second directional signal to one of the at least another amusement vehicle in substantial alignment with the transmitter; the controller being at least one of: operably connected to the receiver and being configured to decode the first signal for controlling the motor in accordance with instructions included in the firs

Abstract: Salinomycin analogs and pharmaceutically acceptable compositions containing salinomycin analogs. Dosage forms and kits comprising salinomycin analogs and pharmaceutically acceptable compositions containing salinomycin analogs. Methods of using salinomycin analogs, pharmaceutically acceptable compositions, dosage forms, and kits for the treatment of proliferative diseases, e.g.

Abstract: There are provided methods for preparing diorganozinc compounds of formula R2Zn. For example, such a method can method comprise reacting together a compound of formula ZnX2 with at least one compound chosen from compounds of formulas RM1T, R2M1, and RM2. R, X, M1, M2, and T can be various different chemical entities. Compounds of formula R2ZnR3, in which R2 and R3 are the same or different, can also prepared in a similar manner.

Abstract: There are provided methods for preparing diorganozinc compounds of formula R2Zn. For example, such a method can method comprise reacting together a compound of formula ZnX2 with at least one compound chosen from compounds of formulas RM1T, R2M1, and RM2. R, X, M1, M2, and T can be various different chemical entities.