Patents by Inventor Alexandre Loboda
Alexandre Loboda has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11630050Abstract: The invention relates to methods and devices for analysis of samples using laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS). The invention provides methods and devices in which individual ablation plumes are distinctively captured and transferred to the ICP, followed by analysis by mass cytometry.Type: GrantFiled: July 22, 2021Date of Patent: April 18, 2023Assignee: STANDARD BIOTOOLS CANADA INC.Inventor: Alexandre Loboda
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Patent number: 11099116Abstract: The invention relates to methods and devices for analysis of samples using laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS). The invention provides methods and devices in which individual ablation plumes are distinctively captured and transferred to the ICP, followed by analysis by mass cytometry.Type: GrantFiled: June 8, 2020Date of Patent: August 24, 2021Assignee: FLUIDIGM CANADA INC.Inventor: Alexandre Loboda
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Publication number: 20200408662Abstract: The invention relates to methods and devices for analysis of samples using laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS). The invention provides methods and devices in which individual ablation plumes are distinctively captured and transferred to the ICP, followed by analysis by mass cytometry.Type: ApplicationFiled: June 8, 2020Publication date: December 31, 2020Inventor: Alexandre Loboda
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Patent number: 10705006Abstract: The invention relates to methods and devices for analysis of samples using laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS). The invention provides methods and devices in which individual ablation plumes are distinctively captured and transferred to the ICP, followed by analysis by mass cytometry.Type: GrantFiled: February 7, 2019Date of Patent: July 7, 2020Assignee: FLUIDIGM CANADA INC.Inventor: Alexandre Loboda
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Publication number: 20190271630Abstract: The invention relates to methods and devices for analysis of samples using laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS). The invention provides methods and devices in which individual ablation plumes are distinctively captured and transferred to the ICP, followed by analysis by mass cytometry.Type: ApplicationFiled: February 7, 2019Publication date: September 5, 2019Inventor: Alexandre Loboda
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Patent number: 10241023Abstract: The invention relates to methods and devices for analysis of samples using laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS). The invention provides methods and devices in which individual ablation plumes are distinctively captured and transferred to the ICP, followed by analysis by mass cytometry.Type: GrantFiled: April 18, 2018Date of Patent: March 26, 2019Assignee: Fluidigm Canada Inc.Inventor: Alexandre Loboda
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Publication number: 20180306695Abstract: The invention relates to methods and devices for analysis of samples using laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS). The invention provides methods and devices in which individual ablation plumes are distinctively captured and transferred to the ICP, followed by analysis by mass cytometry.Type: ApplicationFiled: April 18, 2018Publication date: October 25, 2018Inventor: Alexandre Loboda
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Patent number: 9952132Abstract: The invention relates to methods and devices for analysis of samples using laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS). The invention provides methods and devices in which individual ablation plumes are distinctively captured and transferred to the ICP, followed by analysis by mass cytometry.Type: GrantFiled: January 18, 2017Date of Patent: April 24, 2018Assignee: Fluidigm Canada Inc.Inventor: Alexandre Loboda
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Publication number: 20170248507Abstract: The invention relates to methods and devices for analysis of samples using laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS). The invention provides methods and devices in which individual ablation plumes are distinctively captured and transferred to the ICP, followed by analysis by mass cytometry.Type: ApplicationFiled: January 18, 2017Publication date: August 31, 2017Inventor: Alexandre Loboda
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Patent number: 9653273Abstract: Ion optics devices and related methods of making and using the same are disclosed herein that generally involve forming a plurality of electrode structures on a single substrate. An aspect ratio of the structures relative to a plurality of recesses which separate the structures can be selected so as to substantially prevent ions passing through the finished device from contacting exposed, electrically-insulating portions of the substrate. The substrate material can be a material that is relatively inexpensive and easy to machine into complex shapes with high precision (e.g., a printed circuit board material). In some embodiments, discrete ion optical elements are disclosed which can be formed from a core material to which an electrically-conductive coating is applied, the core material being relatively inexpensive and easy to machine with high precision. The coating can be configured to substantially prevent outgassing from the core under the vacuum conditions typically experienced in a mass spectrometer.Type: GrantFiled: December 6, 2012Date of Patent: May 16, 2017Assignee: DH Technologies Development Pte. Ltd.Inventors: William Morgan Loyd, Alexandre Loboda, Gregor Sprah, Igor V. Chernushevich
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Patent number: 9589779Abstract: The invention relates to methods and devices for analysis of samples using laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS). The invention provides methods and devices in which individual ablation plumes are distinctively captured and transferred to the ICP, followed by analysis by mass cytometry.Type: GrantFiled: April 17, 2014Date of Patent: March 7, 2017Assignee: Fluidigm Canada Inc.Inventor: Alexandre Loboda
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Patent number: 9431228Abstract: An ion lens for reducing contaminant effects in an ion guide of a mass spectrometer is provided. The ion lens comprises a structural member comprising an orifice of a given radius, the structural member for supporting the ion lens at an exit region of the ion guide. The ion lens further comprises a conical member extending from the structural member, the conical member being hollow and comprising a given cone angle, and a base of the given radius, a perimeter of the base connected to a perimeter of the orifice. The conical member further comprises an aperture through an apex of the conical member, the aperture for receiving ions there through from the ion guide.Type: GrantFiled: May 10, 2011Date of Patent: August 30, 2016Assignee: DH Technologies Development Pte. Ltd.Inventor: Alexandre Loboda
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Publication number: 20160056031Abstract: The invention relates to methods and devices for analysis of samples using laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS). The invention provides methods and devices in which individual ablation plumes are distinctively captured and transferred to the ICP, followed by analysis by mass cytometry.Type: ApplicationFiled: April 17, 2014Publication date: February 25, 2016Inventor: Alexandre Loboda
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Publication number: 20150318156Abstract: Ion optics devices and related methods of making and using the same are disclosed herein that generally involve forming a plurality of electrode structures on a single substrate. An aspect ratio of the structures relative to a plurality of recesses which separate the structures can be selected so as to substantially prevent ions passing through the finished device from contacting exposed, electrically-insulating portions of the substrate. The substrate material can be a material that is relatively inexpensive and easy to machine into complex shapes with high precision (e.g., a printed circuit board material). In some embodiments, discrete ion optical elements are disclosed which can be formed from a core material to which an electrically- conductive coating is applied, the core material being relatively inexpensive and easy to machine with high precision. The coating can be configured to substantially prevent outgassing from the core under the vacuum conditions typically experienced in a mass spectrometer.Type: ApplicationFiled: December 6, 2012Publication date: November 5, 2015Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.Inventors: William Morgan Loyd, Alexandre Loboda, Gregor Sprah, Igor V. Chernusevich
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Patent number: 8847151Abstract: An apparatus and method for coupling RF and AC signals to provide power to a multipole in a mass spectrometer is provided. A first circuit comprises: an RF power source for providing difference mode power to the multipole via the RF signal; at least one inductor for forming at least one resonant LC circuit with the multipole for providing voltage gain for the RF signal; and a transformer, comprising a secondary tap, the transformer connected in parallel to the RF power source and further connected to the at least one inductor such that the signals injected into the secondary tap are communicated to the at least one resonant LC circuit.Type: GrantFiled: November 15, 2010Date of Patent: September 30, 2014Assignee: DH Technologies Development Pte. Ltd.Inventors: John Vandermey, Alexandre Loboda
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Patent number: 8785845Abstract: Dual TDC-ADC detection systems for time of flight mass spectrometry are disclosed herein. Detection systems based upon TDC generally provide higher timing resolution as opposed to detection systems based upon ADC. However, ADC generally provides increased dynamic range over TDC. By combining TDC and ADC into a tandem detector, and adjusting performance parameters of the respective converter types, the dynamic range of the dual TDC-ADC detection can be extended beyond what either detector type could have achieved individually. Composite time of flight mass spectra can be generated by aggregating individual mass spectra acquired from multiple time-of-flight extractions, and selecting the number of time-of-flight extractions to ensure overlap between the ADC and TDC dynamic ranges in the dual TDC-ADC detector system.Type: GrantFiled: January 31, 2011Date of Patent: July 22, 2014Assignee: DH Technologies Development Pte. Ltd.Inventor: Alexandre Loboda
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Patent number: 8680463Abstract: Systems, methods and apparatus for radial amplitude assisted transfer (RAAT) in mass spectrometers are provided in which ions for RAAT are accelerated along a longitudinal axis of a mass spectrometer in order to decrease the magnitude of excitation energy of radially excited ions in an ion trap that allows the radially excited ions to exit the ion trap. Hence, the radially excited ions exit the ion trap with reduced radial energy thereby decreasing the exit angle of the radially exited ions from the ion trap. Furthermore, combined forces on the ions are such that radially excited ions exit the ion trap while unexcited ions remain in the ion trap.Type: GrantFiled: August 3, 2011Date of Patent: March 25, 2014Assignee: DH Technologies Development Pte. Ltd.Inventor: Alexandre Loboda
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Publication number: 20130299689Abstract: Systems, methods and apparatus for radial amplitude assisted transfer (RAAT) in mass spectrometers are provided in which ions for RAAT are accelerated along a longitudinal axis of a mass spectrometer in order to decrease the magnitude of excitation energy of radially excited ions in an ion trap that allows the radially excited ions to exit the ion trap. Hence, the radially excited ions exit the ion trap with reduced radial energy thereby decreasing the exit angle of the radially exited ions from the ion trap. Furthermore, combined forces on the ions are such that radially excited ions exit the ion trap while unexcited ions remain in the ion trap.Type: ApplicationFiled: August 3, 2011Publication date: November 14, 2013Inventor: Alexandre Loboda
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Patent number: 8481926Abstract: A method and mass spectrometer for filtering ions are provided. The mass spectrometer generally comprises an ion guide, a quadrupole mass filter, a collision cell and a time of flight (ToF) detector, and is enabled to transmit an ion beam through to the ToF detector. The mass spectrometer is operated in MS mode, such that ions in the ion beam remain substantially unfragmented, the quadrupole mass filter operating at a pressure substantially lower than in either of the ion guide and the collision cell. The quadrupole mass filter is operated in a bandpass mode such that ions outside of a range of interest are filtered from the ion beam, leaving ions inside the range of interest in the ion beam. The ions inside the range of interest are analyzed at the ToF detector.Type: GrantFiled: September 1, 2010Date of Patent: July 9, 2013Assignee: DH Technologies Development Pte. Ltd.Inventor: Alexandre Loboda
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Publication number: 20130140454Abstract: An ion lens for reducing contaminant effects in an ion guide of a mass spectrometer is provided. The ion lens comprises a structural member comprising an orifice of a given radius, the structural member for supporting the ion lens at an exit region of the ion guide. The ion lens further comprises a conical member extending from the structural member, the conical member being hollow and comprising a given cone angle, and a base of the given radius, a perimeter of the base connected to a perimeter of the orifice. The conical member further comprises an aperture through an apex of the conical member, the aperture for receiving ions there through from the ion guide.Type: ApplicationFiled: May 10, 2011Publication date: June 6, 2013Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.Inventor: Alexandre Loboda