Abstract: A liquid handling device having an axis of rotation about which the device can be rotated to drive liquid flow in the device. The device includes an upstream chamber having an outlet, a downstream chamber including a proximal portion radially inwards of a distal portion and including a first port disposed in the distal portion and a first conduit which connects the outlet of the upstream chamber to the first port of the downstream chamber. The first conduit extends radially inwards to a crest and radially outwards from the crest to the first port of the downstream chamber. A distance between the axis of rotation and the crest is greater than or equal to a distance between the axis of rotation and the outlet of the upstream chamber.

Abstract: Disclosed are systems, methods, and other implementations that include a machine-implemented artificial neural network including a plurality of nodes, with the nodes forming at plurality of layers including an input layer, at least one hidden layer, and an output layer, and a plurality of links, with each link coupling a corresponding source node and a receiving node. At least one link is configured to evaluate a piecewise linear function of a value provided by a first source node, from the plurality of nodes, to yield a value for a first receiving node coupled to the at least one link. Each node of a hidden layer is configured to aggregate values provided by links for which that node is the receiving node of the link, with the first receiving node providing non-linear output resulting, in part, from the at least one link configured to evaluate the piecewise linear function.

Abstract: Disclosed are systems, methods, and other implementations that include a machine-implemented artificial neural network including a plurality of nodes, with the nodes forming at plurality of layers including an input layer, at least one hidden layer, and an output layer, and a plurality of links, with each link coupling a corresponding source node and a receiving node. At least one link is configured to evaluate a piecewise linear function of a value provided by a first source node, from the plurality of nodes, to yield a value for a first receiving node coupled to the at least one link Each node of a hidden layer is configured to aggregate values provided by links for which that node is the receiving node of the link, with the first receiving node providing non-linear output resulting, in part, from the at least one link configured to evaluate the piecewise linear function.

Abstract: This invention is about a readout apparatus and method for time-of-flight and energy measurements with silicon photomultipliers (SIPM) coupled to a scintillator. The timing measurement can be as accurate as 50 ps or below, after calibration. The energy is measured using a time-over-threshold technique, and the energy resolution is only constrained by the scintillation statistics. In order to achieve low power of 10 mW per channel, a low impedance input amplifier and analog time-to-digital converters (TDCs) based on time interpolation are used. The readout circuit can be triggered by a single photoelectron (p.e.) with a signal-to-noise ratio (SNR) above 20 dB. The said readout circuit operates with SiPMs of different gain, polarity and matrix size. The preferred embodiment of the readout apparatus is a multi-channel application specific integrated circuit (ASIC) with 64 channels.

Abstract: This invention is about a readout apparatus and method for time-of-flight and energy measurements with silicon photomultipliers (SIPM) coupled to a scintillator. The timing measurement can be as accurate as 50 ps or below, after calibration. The energy is measured using a time-over-threshold technique, and the energy resolution is only constrained by the scintillation statistics. In order to achieve low power of 10 mW per channel, a low impedance input amplifier and analogue time-to-digital converters (TDCs) based on time interpolation are used. The readout circuit can be triggered by a single photoelectron (p.c.) with a signal-to-noise ratio (SNR) above 20 dB. The said readout circuit operates with SiPMs of different gain, polarity and matrix size. The preferred embodiment of the readout apparatus is a multi-channel application specific integrated circuit (ASIC) with 64 channels.

Abstract: Three-dimensional (3D) devices that can receive, harvest or transmit electromagnetic energy with increased efficiency as compared to planar, two-dimensional devices, and methods of making thereof, are disclosed.