Patents by Inventor Alexandre Michalis

Alexandre Michalis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11730953
    Abstract: The present disclosure discusses a system and methods for a deep brain stimulation lead. More particularly, the disclosure discusses a stimulation lead that includes one or more silicon based barrier layers within a MEMS film. The silicon based barrier layers can improve device reliability and durability. The silicon based barrier layers can also improve adhesion between the layers of the MEMS film.
    Type: Grant
    Filed: October 13, 2021
    Date of Patent: August 22, 2023
    Inventors: André Mercanzini, Alain Jordan, Alexandre Michalis, Marc Boers, Alain Dransart
  • Patent number: 11311718
    Abstract: Described herein are microelectrode devices to provide localized neural recording or neural stimulation to a neurological target. The device includes a plurality of electrodes disposed along the shafts of deployable flexible pins. The deployable flexible pins are enclosed within an elongated probe shaft and can be expanded from their enclosure. Additionally, a specifically manufactured outer housing can be coupled to at least a portion of the elongated probe shaft. During deployment of the flexible pins the outer housing of the microelectrode device reduces friction between the flexible pins and the probe shaft and reduces delamination of the flexible pins during deployment.
    Type: Grant
    Filed: April 9, 2019
    Date of Patent: April 26, 2022
    Assignee: ALEVA NEUROTHERAPEUTICS SA
    Inventors: Marc Boers, Andre Mercanzini, Jean-Michel Dougoud, Alexandre Michalis, Khoa Nguyen
  • Publication number: 20220032043
    Abstract: The present disclosure discusses a system and methods for a deep brain stimulation lead. More particularly, the disclosure discusses a stimulation lead that includes one or more silicon based barrier layers within a MEMS film. The silicon based barrier layers can improve device reliability and durability. The silicon based barrier layers can also improve adhesion between the layers of the MEMS film.
    Type: Application
    Filed: October 13, 2021
    Publication date: February 3, 2022
    Applicant: Aleva Neurotherapeutics
    Inventors: André MERCANZINI, Alain Jordan, Alexandre Michalis, Marc Boers, Alain Dransart
  • Patent number: 11167126
    Abstract: The present disclosure discusses a system and methods for a deep brain stimulation lead. More particularly, the disclosure discusses a stimulation lead that includes one or more silicon based barrier layers within a MEMS film. The silicon based barrier layers can improve device reliability and durability. The silicon based barrier layers can also improve adhesion between the layers of the MEMS film.
    Type: Grant
    Filed: August 26, 2019
    Date of Patent: November 9, 2021
    Assignee: ALEVA NEUROTHERAPEUTICS
    Inventors: André Mercanzini, Alain Jordan, Alexandre Michalis, Marc Boers, Alain Dransart
  • Patent number: 10966620
    Abstract: Described herein are microelectrode devices to provide localized neural recording or neural stimulation to a neurological target. The device includes a plurality of electrodes disposed along the shafts of deployable flexible pins. The deployable flexible pins are enclosed within an elongated probe shaft, and can be expanded from their enclosure. Additionally, a specifically manufactured outer housing can be coupled to at least a portion of the elongated probe shaft. During deployment of the flexible pins the outer housing of the microelectrode device reduces friction between the flexible pins and the probe shaft and reduces delamination of the flexible pins during deployment.
    Type: Grant
    Filed: May 15, 2015
    Date of Patent: April 6, 2021
    Assignee: Aleva Neurotherapeutics SA
    Inventors: Marc Boers, Andre Mercanzini, Jean-Michel Dougoud, Alexandre Michalis
  • Publication number: 20200009372
    Abstract: The present disclosure discusses a system and methods for a deep brain stimulation lead. More particularly, the disclosure discusses a stimulation lead that includes one or more silicon based barrier layers within a MEMS film. The silicon based barrier layers can improve device reliability and durability. The silicon based barrier layers can also improve adhesion between the layers of the MEMS film.
    Type: Application
    Filed: August 26, 2019
    Publication date: January 9, 2020
    Inventors: André MERCANZINI, Alain Jordan, Alexandre Michalis, Marc Boers, Alain Dransart
  • Publication number: 20190329050
    Abstract: The present disclosure describes system and methods to configure an implantable neurostimulation device. The system can include a programmer for neurostimulation devices. The programmer can be a handheld device that programs the stimulation parameters for both new and existing patients. The programmer can configure the neurostimulation device to iteratively deliver stimulations through each of the lead's electrodes. The programmer can receive and record indications of the patient's response to each of the stimulations and generate benefit scores or side effect scores based on the patient's response. The programmer can determine the scores based on data received from patient monitors, external sensors, and clinician input. Based on the scores, the programmer can generate therapeutic windows for each of the electrodes. The programmer can combine the therapeutic windows into a therapeutic window map.
    Type: Application
    Filed: April 25, 2018
    Publication date: October 31, 2019
    Inventors: Jean-Charles Montavon, Alexandre Michalis, Pascal Harbi
  • Patent number: 10441779
    Abstract: The present disclosure discusses a system and methods for a deep brain stimulation lead. More particularly, the disclosure discusses a stimulation lead that includes one or more silicon based barrier layers within a MEMS film. The silicon based barrier layers can improve device reliability and durability. The silicon based barrier layers can also improve adhesion between the layers of the MEMS film.
    Type: Grant
    Filed: June 22, 2018
    Date of Patent: October 15, 2019
    Assignee: ALEVA NEUROTHERAPEUTICS
    Inventors: Andre Mercanzini, Alain Jordan, Alexandre Michalis, Marc Boers, Alain Dransart
  • Publication number: 20190232050
    Abstract: Described herein are microelectrode devices to provide localized neural recording or neural stimulation to a neurological target. The device includes a plurality of electrodes disposed along the shafts of deployable flexible pins. The deployable flexible pins are enclosed within an elongated probe shaft and can be expanded from their enclosure. Additionally, a specifically manufactured outer housing can be coupled to at least a portion of the elongated probe shaft. During deployment of the flexible pins the outer housing of the microelectrode device reduces friction between the flexible pins and the probe shaft and reduces delamination of the flexible pins during deployment.
    Type: Application
    Filed: April 9, 2019
    Publication date: August 1, 2019
    Inventors: Marc Boers, Andre Mercanzini, Jean-Michel Dougoud, Alexandre Michalis, Khoa Nguyen
  • Patent number: 10201707
    Abstract: Techniques using electrical stimulation for treating an Autoimmune Disease by means of an implantable pulse generator and at least one electrode. An electrode lead is surgically implanted in a region of the insular cortex to deliver electrical stimulation. The at least one electrode lead and implantable pulse generator contain features that allow the electrical stimulation to be directed to specific volumes of the insular cortex, and ensure that non-therapeutic volumes do not receive electrical stimulation.
    Type: Grant
    Filed: January 23, 2018
    Date of Patent: February 12, 2019
    Assignee: ALEVA NEUROTHERAPEUTICS
    Inventors: Ingo Hartig, Andre Mercanzini, Alain Jordan, Alexandre Michalis, Marc Boers, Alain Dransart
  • Publication number: 20180296825
    Abstract: The present disclosure discusses a system and methods for a deep brain stimulation lead. More particularly, the disclosure discusses a stimulation lead that includes one or more silicon based barrier layers within a MEMS film. The silicon based barrier layers can improve device reliability and durability. The silicon based barrier layers can also improve adhesion between the layers of the MEMS film.
    Type: Application
    Filed: June 22, 2018
    Publication date: October 18, 2018
    Inventors: Andre Mercanzini, Alain Jordan, Alexandre Michalis, Marc Boers, Alain Dransart
  • Patent number: 10065031
    Abstract: The present disclosure discusses a system and methods for a deep brain stimulation lead. More particularly, the disclosure discusses a stimulation lead that includes one or more silicon based barrier layers within a MEMS film. The silicon based barrier layers can improve device reliability and durability. The silicon based barrier layers can also improve adhesion between the layers of the MEMS film.
    Type: Grant
    Filed: September 30, 2016
    Date of Patent: September 4, 2018
    Assignee: ALEVA NEUROTHERAPEUTICS
    Inventors: Andre Mercanzini, Alain Jordan, Alexandre Michalis, Marc Boers, Alain Dransart
  • Patent number: 10004895
    Abstract: The present disclosure discusses a system and methods for a deep brain stimulation lead. More particularly, the disclosure discusses a stimulation lead that includes one or more silicon based barrier layers within a MEMS film. The silicon based barrier layers can improve device reliability and durability. The silicon based barrier layers can also improve adhesion between the layers of the MEMS film.
    Type: Grant
    Filed: September 30, 2016
    Date of Patent: June 26, 2018
    Assignee: ALEVA NEUROTHERAPEUTICS
    Inventors: Andre Mercanzini, Alain Jordan, Alexandre Michalis, Marc Boers, Alain Dransart
  • Publication number: 20180161574
    Abstract: Techniques using electrical stimulation for treating an Autoimmune Disease by means of an implantable pulse generator and at least one electrode. An electrode lead is surgically implanted in a region of the insular cortex to deliver electrical stimulation. The at least one electrode lead and implantable pulse generator contain features that allow the electrical stimulation to be directed to specific volumes of the insular cortex, and ensure that non-therapeutic volumes do not receive electrical stimulation.
    Type: Application
    Filed: January 23, 2018
    Publication date: June 14, 2018
    Inventors: Ingo Hartig, Andre Mercanzini, Alain Jordan, Alexandre Michalis, Marc Boers, Alain Dransart
  • Patent number: 9925376
    Abstract: Techniques using electrical stimulation for treating an Autoimmune Disease by means of an implantable pulse generator and at least one electrode. An electrode lead is surgically implanted in a region of the insular cortex to deliver electrical stimulation. The at least one electrode lead and implantable pulse generator contain features that allow the electrical stimulation to be directed to specific volumes of the insular cortex, and ensure that non-therapeutic volumes do not receive electrical stimulation.
    Type: Grant
    Filed: February 1, 2017
    Date of Patent: March 27, 2018
    Assignee: ALEVA NEUROTHERAPEUTICS
    Inventors: Ingo Hartig, Andre Mercanzini, Alain Jordan, Alexandre Michalis, Marc Boers, Alain Dransart
  • Publication number: 20170136238
    Abstract: Techniques using electrical stimulation for treating an Autoimmune Disease by means of an implantable pulse generator and at least one electrode. An electrode lead is surgically implanted in a region of the insular cortex to deliver electrical stimulation. The at least one electrode lead and implantable pulse generator contain features that allow the electrical stimulation to be directed to specific volumes of the insular cortex, and ensure that non-therapeutic volumes do not receive electrical stimulation.
    Type: Application
    Filed: February 1, 2017
    Publication date: May 18, 2017
    Inventors: Ingo Hartig, Andre Mercanzini, Alain Jordan, Alexandre Michalis, Marc Boers, Alain Dransart
  • Publication number: 20170105641
    Abstract: Described herein are microelectrode devices to provide localized neural recording or neural stimulation to a neurological target. The device includes a plurality of electrodes disposed along the shafts of deployable flexible pins. The deployable flexible pins are enclosed within an elongated probe shaft, and can be expanded from their enclosure. Additionally, a specifically manufactured outer housing can be coupled to at least a portion of the elongated probe shaft. During deployment of the flexible pins the outer housing of the microelectrode device reduces friction between the flexible pins and the probe shaft and reduces delamination of the flexible pins during deployment.
    Type: Application
    Filed: May 15, 2015
    Publication date: April 20, 2017
    Inventors: Marc BOERS, Andre MERCANZINI, Jean-Michel DOUGOUD, Alexandre MICHALIS
  • Publication number: 20170028191
    Abstract: The present disclosure discusses a system and methods for a deep brain stimulation lead. More particularly, the disclosure discusses a stimulation lead that includes one or more silicon based barrier layers within a MEMS film. The silicon based barrier layers can improve device reliability and durability. The silicon based barrier layers can also improve adhesion between the layers of the MEMS film.
    Type: Application
    Filed: September 30, 2016
    Publication date: February 2, 2017
    Inventors: Andre Mercanzini, Alain Jordan, Alexandre Michalis, Marc Boers, Alain Dransart
  • Patent number: 9517132
    Abstract: The present invention concerns an actuating device for actuating a mechanical adjustment element of surgical implant, said mechanical adjustment element allowing to modify the functional shape and/or the functional size of the surgical implant when actuated, said actuating device comprising transmission means linked with one end to the mechanical adjustment element and able to move the mechanical adjustment element when said transmission means are actuated, connecting means (7) mounted on the other end of the transmission means and able to actuate the transmission means, said connecting means (7) comprising coupling means and driving means (24) comprising complementary shaped coupling means, said driving means (24) being designed to be removable and fitted into the coupling means for moving the mechanical adjustment element by driving into movement a movable part of the connecting means (7).
    Type: Grant
    Filed: August 2, 2012
    Date of Patent: December 13, 2016
    Assignee: Centre Hospitalier Universitaire Vaudois
    Inventors: Piergiorgio Tozzi, Alexandre Michalis, Enzo Borghi, Daniel Hayoz
  • Patent number: 9474894
    Abstract: The present disclosure discusses a system and methods for a deep brain stimulation lead. More particularly, the disclosure discusses a stimulation lead that includes one or more silicon based barrier layers within a MEMS film. The silicon based barrier layers can improve device reliability and durability. The silicon based barrier layers can also improve adhesion between the layers of the MEMS film.
    Type: Grant
    Filed: August 27, 2014
    Date of Patent: October 25, 2016
    Assignee: ALEVA NEUROTHERAPEUTICS
    Inventors: Andre Mercanzini, Alain Jordan, Alexandre Michalis, Marc Boers, Alain Dransart