Patents by Inventor Alexandre Michalis
Alexandre Michalis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11730953Abstract: The present disclosure discusses a system and methods for a deep brain stimulation lead. More particularly, the disclosure discusses a stimulation lead that includes one or more silicon based barrier layers within a MEMS film. The silicon based barrier layers can improve device reliability and durability. The silicon based barrier layers can also improve adhesion between the layers of the MEMS film.Type: GrantFiled: October 13, 2021Date of Patent: August 22, 2023Inventors: André Mercanzini, Alain Jordan, Alexandre Michalis, Marc Boers, Alain Dransart
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Patent number: 11311718Abstract: Described herein are microelectrode devices to provide localized neural recording or neural stimulation to a neurological target. The device includes a plurality of electrodes disposed along the shafts of deployable flexible pins. The deployable flexible pins are enclosed within an elongated probe shaft and can be expanded from their enclosure. Additionally, a specifically manufactured outer housing can be coupled to at least a portion of the elongated probe shaft. During deployment of the flexible pins the outer housing of the microelectrode device reduces friction between the flexible pins and the probe shaft and reduces delamination of the flexible pins during deployment.Type: GrantFiled: April 9, 2019Date of Patent: April 26, 2022Assignee: ALEVA NEUROTHERAPEUTICS SAInventors: Marc Boers, Andre Mercanzini, Jean-Michel Dougoud, Alexandre Michalis, Khoa Nguyen
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Publication number: 20220032043Abstract: The present disclosure discusses a system and methods for a deep brain stimulation lead. More particularly, the disclosure discusses a stimulation lead that includes one or more silicon based barrier layers within a MEMS film. The silicon based barrier layers can improve device reliability and durability. The silicon based barrier layers can also improve adhesion between the layers of the MEMS film.Type: ApplicationFiled: October 13, 2021Publication date: February 3, 2022Applicant: Aleva NeurotherapeuticsInventors: André MERCANZINI, Alain Jordan, Alexandre Michalis, Marc Boers, Alain Dransart
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Patent number: 11167126Abstract: The present disclosure discusses a system and methods for a deep brain stimulation lead. More particularly, the disclosure discusses a stimulation lead that includes one or more silicon based barrier layers within a MEMS film. The silicon based barrier layers can improve device reliability and durability. The silicon based barrier layers can also improve adhesion between the layers of the MEMS film.Type: GrantFiled: August 26, 2019Date of Patent: November 9, 2021Assignee: ALEVA NEUROTHERAPEUTICSInventors: André Mercanzini, Alain Jordan, Alexandre Michalis, Marc Boers, Alain Dransart
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Patent number: 10966620Abstract: Described herein are microelectrode devices to provide localized neural recording or neural stimulation to a neurological target. The device includes a plurality of electrodes disposed along the shafts of deployable flexible pins. The deployable flexible pins are enclosed within an elongated probe shaft, and can be expanded from their enclosure. Additionally, a specifically manufactured outer housing can be coupled to at least a portion of the elongated probe shaft. During deployment of the flexible pins the outer housing of the microelectrode device reduces friction between the flexible pins and the probe shaft and reduces delamination of the flexible pins during deployment.Type: GrantFiled: May 15, 2015Date of Patent: April 6, 2021Assignee: Aleva Neurotherapeutics SAInventors: Marc Boers, Andre Mercanzini, Jean-Michel Dougoud, Alexandre Michalis
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Publication number: 20200009372Abstract: The present disclosure discusses a system and methods for a deep brain stimulation lead. More particularly, the disclosure discusses a stimulation lead that includes one or more silicon based barrier layers within a MEMS film. The silicon based barrier layers can improve device reliability and durability. The silicon based barrier layers can also improve adhesion between the layers of the MEMS film.Type: ApplicationFiled: August 26, 2019Publication date: January 9, 2020Inventors: André MERCANZINI, Alain Jordan, Alexandre Michalis, Marc Boers, Alain Dransart
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Publication number: 20190329050Abstract: The present disclosure describes system and methods to configure an implantable neurostimulation device. The system can include a programmer for neurostimulation devices. The programmer can be a handheld device that programs the stimulation parameters for both new and existing patients. The programmer can configure the neurostimulation device to iteratively deliver stimulations through each of the lead's electrodes. The programmer can receive and record indications of the patient's response to each of the stimulations and generate benefit scores or side effect scores based on the patient's response. The programmer can determine the scores based on data received from patient monitors, external sensors, and clinician input. Based on the scores, the programmer can generate therapeutic windows for each of the electrodes. The programmer can combine the therapeutic windows into a therapeutic window map.Type: ApplicationFiled: April 25, 2018Publication date: October 31, 2019Inventors: Jean-Charles Montavon, Alexandre Michalis, Pascal Harbi
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Patent number: 10441779Abstract: The present disclosure discusses a system and methods for a deep brain stimulation lead. More particularly, the disclosure discusses a stimulation lead that includes one or more silicon based barrier layers within a MEMS film. The silicon based barrier layers can improve device reliability and durability. The silicon based barrier layers can also improve adhesion between the layers of the MEMS film.Type: GrantFiled: June 22, 2018Date of Patent: October 15, 2019Assignee: ALEVA NEUROTHERAPEUTICSInventors: Andre Mercanzini, Alain Jordan, Alexandre Michalis, Marc Boers, Alain Dransart
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Publication number: 20190232050Abstract: Described herein are microelectrode devices to provide localized neural recording or neural stimulation to a neurological target. The device includes a plurality of electrodes disposed along the shafts of deployable flexible pins. The deployable flexible pins are enclosed within an elongated probe shaft and can be expanded from their enclosure. Additionally, a specifically manufactured outer housing can be coupled to at least a portion of the elongated probe shaft. During deployment of the flexible pins the outer housing of the microelectrode device reduces friction between the flexible pins and the probe shaft and reduces delamination of the flexible pins during deployment.Type: ApplicationFiled: April 9, 2019Publication date: August 1, 2019Inventors: Marc Boers, Andre Mercanzini, Jean-Michel Dougoud, Alexandre Michalis, Khoa Nguyen
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Patent number: 10201707Abstract: Techniques using electrical stimulation for treating an Autoimmune Disease by means of an implantable pulse generator and at least one electrode. An electrode lead is surgically implanted in a region of the insular cortex to deliver electrical stimulation. The at least one electrode lead and implantable pulse generator contain features that allow the electrical stimulation to be directed to specific volumes of the insular cortex, and ensure that non-therapeutic volumes do not receive electrical stimulation.Type: GrantFiled: January 23, 2018Date of Patent: February 12, 2019Assignee: ALEVA NEUROTHERAPEUTICSInventors: Ingo Hartig, Andre Mercanzini, Alain Jordan, Alexandre Michalis, Marc Boers, Alain Dransart
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Publication number: 20180296825Abstract: The present disclosure discusses a system and methods for a deep brain stimulation lead. More particularly, the disclosure discusses a stimulation lead that includes one or more silicon based barrier layers within a MEMS film. The silicon based barrier layers can improve device reliability and durability. The silicon based barrier layers can also improve adhesion between the layers of the MEMS film.Type: ApplicationFiled: June 22, 2018Publication date: October 18, 2018Inventors: Andre Mercanzini, Alain Jordan, Alexandre Michalis, Marc Boers, Alain Dransart
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Patent number: 10065031Abstract: The present disclosure discusses a system and methods for a deep brain stimulation lead. More particularly, the disclosure discusses a stimulation lead that includes one or more silicon based barrier layers within a MEMS film. The silicon based barrier layers can improve device reliability and durability. The silicon based barrier layers can also improve adhesion between the layers of the MEMS film.Type: GrantFiled: September 30, 2016Date of Patent: September 4, 2018Assignee: ALEVA NEUROTHERAPEUTICSInventors: Andre Mercanzini, Alain Jordan, Alexandre Michalis, Marc Boers, Alain Dransart
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Patent number: 10004895Abstract: The present disclosure discusses a system and methods for a deep brain stimulation lead. More particularly, the disclosure discusses a stimulation lead that includes one or more silicon based barrier layers within a MEMS film. The silicon based barrier layers can improve device reliability and durability. The silicon based barrier layers can also improve adhesion between the layers of the MEMS film.Type: GrantFiled: September 30, 2016Date of Patent: June 26, 2018Assignee: ALEVA NEUROTHERAPEUTICSInventors: Andre Mercanzini, Alain Jordan, Alexandre Michalis, Marc Boers, Alain Dransart
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Publication number: 20180161574Abstract: Techniques using electrical stimulation for treating an Autoimmune Disease by means of an implantable pulse generator and at least one electrode. An electrode lead is surgically implanted in a region of the insular cortex to deliver electrical stimulation. The at least one electrode lead and implantable pulse generator contain features that allow the electrical stimulation to be directed to specific volumes of the insular cortex, and ensure that non-therapeutic volumes do not receive electrical stimulation.Type: ApplicationFiled: January 23, 2018Publication date: June 14, 2018Inventors: Ingo Hartig, Andre Mercanzini, Alain Jordan, Alexandre Michalis, Marc Boers, Alain Dransart
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Patent number: 9925376Abstract: Techniques using electrical stimulation for treating an Autoimmune Disease by means of an implantable pulse generator and at least one electrode. An electrode lead is surgically implanted in a region of the insular cortex to deliver electrical stimulation. The at least one electrode lead and implantable pulse generator contain features that allow the electrical stimulation to be directed to specific volumes of the insular cortex, and ensure that non-therapeutic volumes do not receive electrical stimulation.Type: GrantFiled: February 1, 2017Date of Patent: March 27, 2018Assignee: ALEVA NEUROTHERAPEUTICSInventors: Ingo Hartig, Andre Mercanzini, Alain Jordan, Alexandre Michalis, Marc Boers, Alain Dransart
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Publication number: 20170136238Abstract: Techniques using electrical stimulation for treating an Autoimmune Disease by means of an implantable pulse generator and at least one electrode. An electrode lead is surgically implanted in a region of the insular cortex to deliver electrical stimulation. The at least one electrode lead and implantable pulse generator contain features that allow the electrical stimulation to be directed to specific volumes of the insular cortex, and ensure that non-therapeutic volumes do not receive electrical stimulation.Type: ApplicationFiled: February 1, 2017Publication date: May 18, 2017Inventors: Ingo Hartig, Andre Mercanzini, Alain Jordan, Alexandre Michalis, Marc Boers, Alain Dransart
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Publication number: 20170105641Abstract: Described herein are microelectrode devices to provide localized neural recording or neural stimulation to a neurological target. The device includes a plurality of electrodes disposed along the shafts of deployable flexible pins. The deployable flexible pins are enclosed within an elongated probe shaft, and can be expanded from their enclosure. Additionally, a specifically manufactured outer housing can be coupled to at least a portion of the elongated probe shaft. During deployment of the flexible pins the outer housing of the microelectrode device reduces friction between the flexible pins and the probe shaft and reduces delamination of the flexible pins during deployment.Type: ApplicationFiled: May 15, 2015Publication date: April 20, 2017Inventors: Marc BOERS, Andre MERCANZINI, Jean-Michel DOUGOUD, Alexandre MICHALIS
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Publication number: 20170028191Abstract: The present disclosure discusses a system and methods for a deep brain stimulation lead. More particularly, the disclosure discusses a stimulation lead that includes one or more silicon based barrier layers within a MEMS film. The silicon based barrier layers can improve device reliability and durability. The silicon based barrier layers can also improve adhesion between the layers of the MEMS film.Type: ApplicationFiled: September 30, 2016Publication date: February 2, 2017Inventors: Andre Mercanzini, Alain Jordan, Alexandre Michalis, Marc Boers, Alain Dransart
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Patent number: 9517132Abstract: The present invention concerns an actuating device for actuating a mechanical adjustment element of surgical implant, said mechanical adjustment element allowing to modify the functional shape and/or the functional size of the surgical implant when actuated, said actuating device comprising transmission means linked with one end to the mechanical adjustment element and able to move the mechanical adjustment element when said transmission means are actuated, connecting means (7) mounted on the other end of the transmission means and able to actuate the transmission means, said connecting means (7) comprising coupling means and driving means (24) comprising complementary shaped coupling means, said driving means (24) being designed to be removable and fitted into the coupling means for moving the mechanical adjustment element by driving into movement a movable part of the connecting means (7).Type: GrantFiled: August 2, 2012Date of Patent: December 13, 2016Assignee: Centre Hospitalier Universitaire VaudoisInventors: Piergiorgio Tozzi, Alexandre Michalis, Enzo Borghi, Daniel Hayoz
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Patent number: 9474894Abstract: The present disclosure discusses a system and methods for a deep brain stimulation lead. More particularly, the disclosure discusses a stimulation lead that includes one or more silicon based barrier layers within a MEMS film. The silicon based barrier layers can improve device reliability and durability. The silicon based barrier layers can also improve adhesion between the layers of the MEMS film.Type: GrantFiled: August 27, 2014Date of Patent: October 25, 2016Assignee: ALEVA NEUROTHERAPEUTICSInventors: Andre Mercanzini, Alain Jordan, Alexandre Michalis, Marc Boers, Alain Dransart